2022
Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis
Yang C, Sobkowiak B, Naidu V, Codreanu A, Ciobanu N, Gunasekera KS, Chitwood MH, Alexandru S, Bivol S, Russi M, Havumaki J, Cudahy P, Fosburgh H, Allender CJ, Centner H, Engelthaler DM, Menzies NA, Warren JL, Crudu V, Colijn C, Cohen T. Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis. PLOS Medicine 2022, 19: e1003933. PMID: 35192619, PMCID: PMC8903246, DOI: 10.1371/journal.pmed.1003933.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisDrug-resistant M. tuberculosisM. tuberculosis strainsPutative transmission clustersM. tuberculosisTransmission clustersMultidrug-resistant M. tuberculosis strainsTuberculosis strainsMultiple M. tuberculosis strainsCulture-positive TB casesLocal transmissionMDR-TB epidemicDrug-susceptible tuberculosisDrug resistance mutationsDrug resistance profilesUrgency of interventionTB casesDemographic dataNew casesTuberculosisInadequate treatmentNatural historyResistance mutationsBeijing lineageMycobacterium tuberculosis
2021
Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova
Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microbial Genomics 2021, 7: 000620. PMID: 34431762, PMCID: PMC8549355, DOI: 10.1099/mgen.0.000620.Peer-Reviewed Original ResearchConceptsDrug-resistant TB casesMultidrug-resistant Mycobacterium tuberculosisDrug-resistant tuberculosisDrug resistance mutationsPopulation size expansionPublic health practiceSoviet UnionSocial turmoilTB patientsTB casesTB controlRepublic of MoldovaInpatient hospitalizationMigration historyInpatient treatmentEastern EuropeNational guidelinesEpidemiological historyResistance mutationsHealth practicesGenomic surveillance effortsCapital cityMycobacterium tuberculosisTuberculosisMoldova
2020
Evaluation of 6-Month Versus Continuous Isoniazid Preventive Therapy for Mycobacterium tuberculosis in Adults Living With HIV/AIDS in Malawi.
Hsieh YL, Jahn A, Menzies NA, Yaesoubi R, Salomon JA, Girma B, Gunde L, Eaton JW, Auld A, Odo M, Kiyiika CN, Kalua T, Chiwandira B, Mpunga JU, Mbendra K, Corbett L, Hosseinipour MC, Cohen T, Kunkel A. Evaluation of 6-Month Versus Continuous Isoniazid Preventive Therapy for Mycobacterium tuberculosis in Adults Living With HIV/AIDS in Malawi. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 85: 643-650. PMID: 33177475, PMCID: PMC8564780, DOI: 10.1097/qai.0000000000002497.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyIPT programIPT strategyPreventive therapyContinuous isoniazid preventive therapyMore TB casesHIV-positive adultsCases of tuberculosisAnticipated health effectsComparable health benefitsHIV/AIDSCause deathAntiretroviral therapyTB casesTB controlTB incidenceDrug costsMalawi MinistryMean reductionTuberculosisMycobacterium tuberculosisTherapyAnticipated health impactsHealth effectsHealth benefits
2016
Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis
Lieberman TD, Wilson D, Misra R, Xiong LL, Moodley P, Cohen T, Kishony R. Genomic diversity in autopsy samples reveals within-host dissemination of HIV-associated Mycobacterium tuberculosis. Nature Medicine 2016, 22: 1470-1474. PMID: 27798613, PMCID: PMC5508070, DOI: 10.1038/nm.4205.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAutopsyBacteriological TechniquesCoinfectionDNA, BacterialFemaleGenetic VariationHIV InfectionsHumansLiverLungLymph NodesMaleMiddle AgedMycobacterium tuberculosisPhylogenyPolymorphism, Single NucleotideSouth AfricaSpleenTuberculosisTuberculosis, HepaticTuberculosis, Lymph NodeTuberculosis, PulmonaryTuberculosis, SplenicConceptsMycobacterium tuberculosisPostmortem biopsiesAutopsy samplesTuberculosisHost disseminationHIVBiopsyThe transmission of Mycobacterium tuberculosis in high burden settings
Yates TA, Khan PY, Knight GM, Taylor JG, McHugh TD, Lipman M, White RG, Cohen T, Cobelens FG, Wood R, Moore DA, Abubakar I. The transmission of Mycobacterium tuberculosis in high burden settings. The Lancet Infectious Diseases 2016, 16: 227-238. PMID: 26867464, DOI: 10.1016/s1473-3099(15)00499-5.Peer-Reviewed Original ResearchConceptsHigh-burden settingsBurden settingsTuberculosis infection controlMycobacterium tuberculosis transmissionEffects of HIVHealth care workersDrug-resistant strainsAntiretroviral therapyPerson transmissionTuberculosis transmissionInfection controlTransmission riskAirborne transmissionMycobacterium tuberculosisWells-Riley equationPresent research prioritiesTransmission dynamicsResearch prioritiesHIVEffective strategyTherapyTuberculosisSettingTrials
2015
Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study
Salvatore PP, Becerra MC, Wiesch P, Hinkley T, Kaur D, Sloutsky A, Cohen T. Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study. The Journal Of Infectious Diseases 2015, 213: 149-155. PMID: 26092854, PMCID: PMC4676541, DOI: 10.1093/infdis/jiv347.Peer-Reviewed Original ResearchConceptsDrug resistance mutationsCase-control studyKatG Ser315Thr mutationMDR strainsMultiple case householdsResistance mutationsDrug resistance-associated mutationsMycobacterium tuberculosisMultidrug-resistant Mycobacterium tuberculosisSecondary household casesSer315Thr mutationMDR M. tuberculosisMultidrug-resistant tuberculosisMDR Mycobacterium tuberculosisResistance-associated polymorphismsLong-term prevalenceResistance-associated mutationsVivo fitness costsCase-control designEpidemiologic studiesHousehold casesTuberculosisExperimental modelM. tuberculosisMutations
2014
Magnitude and sources of bias in the detection of mixed strain M. tuberculosis infection
Plazzotta G, Cohen T, Colijn C. Magnitude and sources of bias in the detection of mixed strain M. tuberculosis infection. Journal Of Theoretical Biology 2014, 368: 67-73. PMID: 25553967, PMCID: PMC7011203, DOI: 10.1016/j.jtbi.2014.12.009.Peer-Reviewed Original ResearchConceptsMixed infectionsM. tuberculosis infectionIncidence of TBOutcome of treatmentPopulation-level interventionsFraction of casesTuberculosis infectionMinority strainsActual prevalenceInfected individualsInfectionStudy designMycobacterium tuberculosisPrevalenceSputumTuberculosisDistinct strainsDifferent strainsSources of biasPrevious studiesPatientsSpecific reasonsIncidenceIndividuals
2013
Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis
Mills HL, Cohen T, Colijn C. Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis. Science Translational Medicine 2013, 5: 180ra49. PMID: 23576815, PMCID: PMC3714172, DOI: 10.1126/scitranslmed.3005260.Peer-Reviewed Original ResearchConceptsDrug-resistant TBIPT interventionDrug-sensitive infectionsIsoniazid-resistant TBHIV/TBRisk of progressionHigh HIV prevalenceDrug-resistant diseaseIsoniazid-resistant Mycobacterium tuberculosisSymptom-free individualsSignificant elevated riskDrug-resistant strainsWorld Health OrganizationActive TBTB controlResistant tuberculosisHIV prevalenceTuberculosis controlIPT programElevated riskHost immunityMycobacterium tuberculosisHealth OrganizationSelective suppressionIntervention
2012
Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control
Cohen T, van Helden PD, Wilson D, Colijn C, McLaughlin MM, Abubakar I, Warren RM. Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control. Clinical Microbiology Reviews 2012, 25: 708-719. PMID: 23034327, PMCID: PMC3485752, DOI: 10.1128/cmr.00021-12.Peer-Reviewed Original ResearchConceptsMixed infectionsTuberculosis infectionM. tuberculosis infectionTuberculosis control strategiesMycobacterium tuberculosis infectionTreatment of patientsMultiple distinct strainsTuberculosis treatmentInfectionMycobacterium tuberculosisEpidemiological importanceDistinct strainsTreatmentNumerous studiesPatientsTuberculosisDiagnosisHighlight challengesIndividuals
2011
Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru - Volume 17, Number 6—June 2011 - Emerging Infectious Diseases journal - CDC
Cohen T, Murray M, Abubakar I, Zhang Z, Sloutsky A, Arteaga F, Chalco K, Franke MF, Becerra MC. Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru - Volume 17, Number 6—June 2011 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2011, 17: 969-975. PMID: 21749756, PMCID: PMC3358204, DOI: 10.3201/eid1706.101471.Peer-Reviewed Original ResearchConceptsMDR-TB patientsMDR-TBMultidrug-resistant tuberculosisTB patientsOptimal treatment regimensMDR Mycobacterium tuberculosisDrug sensitivity testingHigh incidence areaRepetitive unit-variable number tandem repeatHousehold contactsTreatment regimensHousehold transmissionSecondary casesPatientsMycobacterium tuberculosisSensitivity testingCommunity exposureTuberculosisNumber tandem repeatTBSecond strainExposureRegimensSpoligotypingModels to understand the population-level impact of mixed strain M. tuberculosis infections
Sergeev R, Colijn C, Cohen T. Models to understand the population-level impact of mixed strain M. tuberculosis infections. Journal Of Theoretical Biology 2011, 280: 88-100. PMID: 21514304, PMCID: PMC3111980, DOI: 10.1016/j.jtbi.2011.04.011.Peer-Reviewed Original ResearchConceptsDrug-resistant strainsMixed strain infectionsStrain infectionDrug-sensitive tuberculosisDrug-resistant tuberculosisM. tuberculosis infectionLower basic reproductive numberDrug-resistant infectionsTuberculosis patientsTuberculosis infectionTreatment successDrug-resistant bacteriaFuture burdenLong-term effectsStrain-specific differencesDrug resistanceInfectionPopulation-level impactTuberculosisM. tuberculosisMixed infectionsMycobacterium tuberculosisBasic reproductive numberCo-infected hostsSmall subpopulation
2009
Mathematical models of the epidemiology and control of drug-resistant TB
Cohen T, Dye C, Colijn C, Williams B, Murray M. Mathematical models of the epidemiology and control of drug-resistant TB. Expert Review Of Respiratory Medicine 2009, 3: 67-79. PMID: 20477283, DOI: 10.1586/17476348.3.1.67.Peer-Reviewed Original ResearchDrug-resistant TBDrug resistanceMultiple drug-resistant Mycobacterium tuberculosisDrug-resistant Mycobacterium tuberculosisDrug-resistant M. tuberculosisCombination chemotherapyTB controlM. tuberculosisMycobacterium tuberculosisAntibiotic resistanceRecent reportsTuberculosisEpidemiologyTBExtrinsic determinantsInterventionCost effectivenessReproductive capacityChemotherapyControlPrevalence
2008
Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines
Cohen T, Colijn C, Murray M. Modeling the effects of strain diversity and mechanisms of strain competition on the potential performance of new tuberculosis vaccines. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 16302-16307. PMID: 18849476, PMCID: PMC2570977, DOI: 10.1073/pnas.0808746105.Peer-Reviewed Original ResearchConceptsNew tuberculosis vaccinesTuberculosis vaccineBacillus Calmette-Guérin (BCG) vaccinationCurrent vaccine candidatesM. tuberculosis strainsPerformance of vaccinesTuberculosis infectionTuberculosis controlStrain diversityMass vaccinationVaccine candidatesNew vaccinesTuberculosis strainsStrain replacementVaccineM. tuberculosisMycobacterium tuberculosisTransmission of diseaseVaccinationTuberculosisInfectionDiseaseStrain specificityPotential effectsMorbidityAre Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study
Cohen T, Colijn C, Finklea B, Wright A, Zignol M, Pym A, Murray M. Are Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study. PLOS ONE 2008, 3: e2363. PMID: 18523659, PMCID: PMC2408555, DOI: 10.1371/journal.pone.0002363.Peer-Reviewed Original ResearchConceptsResistant tuberculosisIncident casesTotal burdenDrug-resistant TBDrug-resistant tuberculosisSecond-line antibioticsDrug treatment regimensDrug sensitivity testingDrug-resistant strainsBurden of resistanceEmergence of tuberculosisResistant TBTreatment regimensPrevalent casesWorldwide burdenIntroduction of interventionsRoutine surveillanceSurveillance strategiesDrug resistanceTuberculosisLaboratory capacityMycobacterium tuberculosisSensitivity testingTuberculosis modelBurdenMathematical Modeling of Tuberculosis Transmission Dynamics
Cohen T, Colijn C, Murray M. Mathematical Modeling of Tuberculosis Transmission Dynamics. 2008, 227-243. DOI: 10.1002/9783527611614.ch44.Peer-Reviewed Original ResearchMathematical modelBehavior of epidemicsSimple mathematical modelEpidemic modelMathematical modelingTuberculosis transmission dynamicsTuberculosis dynamicsDynamic modelNatural courseTB epidemicDynamicsNatural historyInfectious diseasesTransmission dynamicsMycobacterium tuberculosisDiseaseModelQuantitative insightsKey parametersInterventionEpidemicImportant toolComplicating factorsPotential effectsModeling
2006
Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmission
Cohen T, Colijn C, Finklea B, Murray M. Exogenous re-infection and the dynamics of tuberculosis epidemics: local effects in a network model of transmission. Journal Of The Royal Society Interface 2006, 4: 523-531. PMID: 17251134, PMCID: PMC2373405, DOI: 10.1098/rsif.2006.0193.Peer-Reviewed Original ResearchConceptsTB control strategiesPublic health policy makersType of TBMolecular epidemiologic toolsHealth policy makersTB diseasePrimary diseasePrimary progressionTB incidenceRecent infectionTB transmissionTuberculosis diseaseInfectious disease transmissionTuberculosis epidemicRecent transmissionEpidemiological dataForce of infectionInfectious casesLatent infectionEpidemiologic toolInfectionMycobacterium tuberculosisSpecific populationsDiseaseEpidemic trajectories
2004
Isoniazid Resistance and the Future of Drug-Resistant Tuberculosis
Cohen T, Becerra MC, Murray MB. Isoniazid Resistance and the Future of Drug-Resistant Tuberculosis. Microbial Drug Resistance 2004, 10: 280-285. PMID: 15650371, PMCID: PMC2652757, DOI: 10.1089/mdr.2004.10.280.Peer-Reviewed Original ResearchConceptsIsoniazid resistanceDrug resistanceDrug-resistant tuberculosisDrug-resistant casesResistance-conferring mutationsFrequency of resistanceMycobacterium tuberculosisAntibiotic resistancePrudent useTuberculosisDeleterious effectsReproductive potentialChromosomal mutationsMutationsSpecific measuresPrevalence
2003
The effect of drug resistance on the fitness of Mycobacterium tuberculosis
Cohen T, Sommers B, Murray M. The effect of drug resistance on the fitness of Mycobacterium tuberculosis. The Lancet Infectious Diseases 2003, 3: 13-21. PMID: 12505028, DOI: 10.1016/s1473-3099(03)00483-3.Peer-Reviewed Original Research