2022
Spatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making
de Villiers AK, Dye C, Yaesoubi R, Cohen T, Marx FM. Spatially targeted digital chest radiography to reduce tuberculosis in high-burden settings: A study of adaptive decision making. Epidemics 2022, 38: 100540. PMID: 35093849, PMCID: PMC8983993, DOI: 10.1016/j.epidem.2022.100540.Peer-Reviewed Original ResearchConceptsHigh-burden settingsTB casesTB prevalenceChest radiographyAdditional TB casesCase-finding yieldTB prevalence estimatesHigh-burden populationsCommunity-randomized trialNumber of screeningsTB controlXpert UltraScreening roundNotification ratesPrevalence estimatesTuberculosisPrevalenceDigital chest radiographyScreeningTrialsInterventionRadiography
2016
Assessing the utility of Xpert® MTB/RIF as a screening tool for patients admitted to medical wards in South Africa
Heidebrecht CL, Podewils LJ, Pym AS, Cohen T, Mthiyane T, Wilson D. Assessing the utility of Xpert® MTB/RIF as a screening tool for patients admitted to medical wards in South Africa. Scientific Reports 2016, 6: 19391. PMID: 26786396, PMCID: PMC4726405, DOI: 10.1038/srep19391.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCoinfectionDrug Resistance, BacterialFemaleHIV InfectionsHumansMaleMass ScreeningMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisNucleic Acid Amplification TechniquesReproducibility of ResultsRifampinSouth AfricaTuberculosis, Multidrug-ResistantYoung AdultConceptsChest X-rayMTB/RIFMedical wardsScreening toolAdditional TB casesInfection control actionsUtility of GeneXpertTB/HIVConsecutive adult patientsProportion of patientsRifampicin-resistant tuberculosisDrug-resistant tuberculosisLarge public hospitalTB diseaseAdult patientsStandard careTB casesTB screeningMedical admissionsMedical chartsHospital inpatientsSputum specimensGeneXpertPatientsRifampicin resistance
2014
Bacillus Calmette-Guérin and Isoniazid Preventive Therapy Protect Contacts of Patients with Tuberculosis
Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T. Bacillus Calmette-Guérin and Isoniazid Preventive Therapy Protect Contacts of Patients with Tuberculosis. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 853-859. PMID: 24592878, PMCID: PMC4225829, DOI: 10.1164/rccm.201310-1896oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAntitubercular AgentsBCG VaccineChildChild, PreschoolContact TracingFemaleFollow-Up StudiesHumansInfantIsoniazidMaleMiddle AgedModels, StatisticalModels, TheoreticalMultivariate AnalysisOdds RatioPeruProspective StudiesTreatment OutcomeTuberculosis, PulmonaryYoung AdultConceptsIsoniazid preventive therapyAge-specific efficacyLatent TB infectionIncident tuberculosisHousehold contactsTB diseaseTB infectionPulmonary tuberculosisRisk ratioUse of IPTObservational prospective cohort studyBacillus Calmette-Guérin (BCG) vaccinationHigh TB burden settingsAdditional TB casesHIV-positive contactsIncident pulmonary tuberculosisHIV-negative childrenProspective cohort studyPublic Health CenterBacillus Calmette-GuérinYear-long followWorld Health OrganizationCohort studyPreventive therapyTB cases