2023
A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial
Boomer T, Hoerner L, Fernandes C, Maslar A, Aiudi S, Kyriakides T, Fiellin L. A digital health game to prevent opioid misuse and promote mental health in adolescents in school-based health settings: Protocol for the PlaySmart game randomized controlled trial. PLOS ONE 2023, 18: e0291298. PMID: 37683047, PMCID: PMC10490848, DOI: 10.1371/journal.pone.0291298.Peer-Reviewed Original ResearchConceptsMental health outcomesOpioid misuseMental healthHealth gamesHealth outcomesMeasures of depressionMental health symptomsGreater riskHelp-seeking behaviorSecondary outcome measuresCritical developmental periodOpioid use disorderPerception of riskRisk of initiationHealth symptomsSchool gradesProfessional helpMisusing opioidsPrimary outcomeDevelopmental periodAdolescentsOutcome measuresSubstance misuseUse disordersHealth settings
2010
Methodological Issues in Comparative Effectiveness Research: Clinical Trials
Peduzzi P, Kyriakides T, O'Connor TZ, Guarino P, Warren SR, Huang GD. Methodological Issues in Comparative Effectiveness Research: Clinical Trials. The American Journal Of Medicine 2010, 123: e8-e15. PMID: 21184867, DOI: 10.1016/j.amjmed.2010.10.003.Peer-Reviewed Original ResearchConceptsComparative effectiveness clinical trialEffectiveness clinical trialClinical trialsVeterans Affairs Cooperative Studies ProgramCooperative Studies ProgramComparative effectiveness researchMechanism of actionUsual careDiabetes mellitusRheumatoid arthritisFuture trialsClinical equipoisePatient preferencesRisk factorsNeurologic disordersInfectious diseasesMental healthTrialsDisease areasEffectiveness researchPharmaceutical issuesType of studyValid comparisonsMellitusArthritis