1999
Stratified Randomization for Clinical Trials
Kernan W, Viscoli C, Makuch R, Brass L, Horwitz R. Stratified Randomization for Clinical Trials. Journal Of Clinical Epidemiology 1999, 52: 19-26. PMID: 9973070, DOI: 10.1016/s0895-4356(98)00138-3.Peer-Reviewed Original ResearchConceptsStratified randomizationSmall trialsInterim analysisActive-control equivalence trialsClinical factorsLarge trialsSuperiority trialSubgroup analysisClinical trialsTreatment responsivenessTreatment outcomesMEDLINE searchTreatment groupsStratification factorsEquivalence trialPrognosisTrialsRandomizationType ITheoretical benefitsImportance of stratificationStratificationSample sizeInvestigatorsPatients
1998
Verapamil use in patients with cardiovascular disease: An overview of randomized trials
Pepine C, Faich G, Makuch R. Verapamil use in patients with cardiovascular disease: An overview of randomized trials. Clinical Cardiology 1998, 21: 633-641. PMID: 9755379, PMCID: PMC6655547, DOI: 10.1002/clc.4960210906.Peer-Reviewed Original ResearchConceptsMyocardial infarctionVerapamil useNonfatal reinfarctionCalcium antagonistsDecreased riskDrug classesCardiovascular diseaseCertain calcium antagonistsNonfatal myocardial infarctionOutcome of deathParallel-group studyStandard meta-analytic techniquesRandomized clinical trialsAcute myocardial infarctionEnglish-language articlesEvidence of harmAngina StudyHypertensive patientsOverall mortalityRandomized studyRandomized trialsTrial characteristicsClinical trialsPatient outcomesMEDLINE search