2023
Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
Collatuzzo G, Negri E, Pelucchi C, Bonzi R, Turati F, Rabkin C, Liao L, Sinha R, Palli D, Ferraroni M, López-Carrillo L, Lunet N, Morais S, Albanes D, Weinstein S, Parisi D, Zaridze D, Maximovitch D, Dierssen-Sotos T, Jiménez-Moleón J, Vioque J, de la Hera M, Curado M, Dias-Neto E, Hernández-Ramírez R, López-Cervantes M, Ward M, Tsugane S, Hidaka A, Lagiou A, Lagiou P, Zhang Z, Trichopoulou A, Karakatsani A, Camargo M, La Vecchia C, Boffetta P. Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium. Nutrients 2023, 15: 1877. PMID: 37111097, PMCID: PMC10147010, DOI: 10.3390/nu15081877.Peer-Reviewed Original ResearchConceptsGastric cancerYoghurt intakeYoghurt consumptionOdds ratioMultivariable unconditional logistic regression modelStomach cancer Pooling (StoP) ProjectStudy-specific odds ratiosUnconditional logistic regression modelsFood frequency questionnairePopulation-based studyConfidence intervalsIntestinal gastric cancerLogistic regression modelsFrequency questionnaireIntestinal casesPooled analysisProtective effectPooling ProjectGut microbiotaGC casesDisease riskGC riskAdditional studiesIntakeCardia
2022
The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project
Alicandro G, Bertuccio P, Collatuzzo G, Pelucchi C, Bonzi R, Liao LM, Rabkin CS, Sinha R, Negri E, Dalmartello M, Zaridze D, Maximovich D, Vioque J, Garcia de la Hera M, Tsugane S, Hidaka A, Hamada GS, López-Carrillo L, Hernández-Ramírez RU, Malekzadeh R, Pourfarzi F, Zhang ZF, Kurtz RC, Camargo MC, Curado MP, Lunet N, Boffetta P, La Vecchia C. The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project. British Journal Of Cancer 2022, 127: 855-862. PMID: 35624300, PMCID: PMC9427973, DOI: 10.1038/s41416-022-01857-9.Peer-Reviewed Original ResearchConceptsLifestyle factorsGastric cancerOdds ratioStomach cancer Pooling (StoP) ProjectWarrants further investigationNatural direct effectNatural indirect effectReduced riskPooling ProjectReference categoryGC casesLower educationComplete dataCausal pathwaysCancerFurther investigationDirect effectMediation analysisLow levelsIndirect effectsPotential pathwaysMediation effectFactorsPathwayIdentifying the profile of Helicobacter pylori negative gastric cancers: a case only analysis within the Stomach cancer Pooling (StoP) Project
Morais S, Peleteiro B, Araújo N, Malekzadeh R, Ye W, Plymoth A, Tsugane S, Hidaka A, Hamada GS, López-Carrillo L, Zaridze D, Maximovich D, Aragonés N, Castaño-Vinyals G, Pakseresht M, Hernández-Ramírez RU, López-Cervantes M, Leja M, Gasenko E, Pourfarzi F, Zhang ZF, Yu GP, Derakhshan MH, Pelucchi C, Negri E, La Vecchia C, Lunet N. Identifying the profile of Helicobacter pylori negative gastric cancers: a case only analysis within the Stomach cancer Pooling (StoP) Project. Cancer Epidemiology Biomarkers & Prevention 2022, 31: cebp.0402.2021. PMID: 34728467, DOI: 10.1158/1055-9965.epi-21-0402.Peer-Reviewed Original ResearchConceptsStomach cancer Pooling (StoP) ProjectGastric cancerNegative gastric cancerGastric atrophyRisk factorsOdds ratioFamily historyPooling ProjectPositive casesGastric cancer risk factorsInfection statusNon-cardia gastric cancerCancer risk factorsFirst-degree relativesHigh-risk profileAbsence of infectionOccurrence of cancerCurrent smokersPooled prevalenceCagA statusHpNGCSerologic testsLow prevalenceAdvanced stageCancer
2021
Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project
Collatuzzo G, Pelucchi C, Negri E, López‐Carrillo L, Tsugane S, Hidaka A, Hamada G, Hernández‐Ramírez R, López‐Cervantes M, Malekzadeh R, Pourfarzi F, Mu L, Zhang Z, Lunet N, La Vecchia C, Boffetta P. Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project. International Journal Of Cancer 2021, 149: 1228-1238. PMID: 33990950, DOI: 10.1002/ijc.33678.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStomach cancer Pooling (StoP) ProjectHP infectionRisk factorsGastric cancerSocioeconomic statusCigarette smokingPooled analysisAlcohol drinkingOdds ratioPooling ProjectMultivariate unconditional logistic regressionDietary salt intakeModifiable risk factorsHelicobacter pylori infectionUnconditional logistic regressionGastric cancer preventionConfidence intervalsCase-control studySummary odds ratiosLifestyle modificationHP eradicationSalt intakeTobacco smokingDietary saltHistologic type
2020
Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project
Ferro A, Costa AR, Morais S, Bertuccio P, Rota M, Pelucchi C, Hu J, Johnson KC, Zhang Z, Palli D, Ferraroni M, Yu G, Bonzi R, Peleteiro B, López‐Carrillo L, Tsugane S, Hamada GS, Hidaka A, Malekzadeh R, Zaridze D, Maximovich D, Vioque J, Navarrete‐Muñoz E, Alguacil J, Castaño‐Vinyals G, Wolk A, Håkansson N, Hernández‐Ramírez R, Pakseresht M, Ward MH, Pourfarzi F, Mu L, López‐Cervantes M, Persiani R, Kurtz RC, Lagiou A, Lagiou P, Boffetta P, Boccia S, Negri E, Camargo MC, Curado MP, La Vecchia C, Lunet N. Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project. International Journal Of Cancer 2020, 147: 3090-3101. PMID: 32525569, PMCID: PMC8545605, DOI: 10.1002/ijc.33134.Peer-Reviewed Original ResearchConceptsGastric cancerGastric cancer riskNoncitrus fruitProtective effectCancer riskStomach cancer Pooling (StoP) ProjectExposure-response analysisPortions/dayConfidence intervalsExposure-response relationsRandom-effects modelPooled analysisRisk factorsDietary recommendationsLow intakeHigh intakePooling ProjectStudy characteristicsCancerNonlinear associationFractional polynomialsIntakeLifestyle categoriesRiskAssociation
2019
Smoking and Helicobacter pylori infection
Ferro A, Morais S, Pelucchi C, Aragonés N, Kogevinas M, López-Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernández-Ramírez RU, López-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Smoking and Helicobacter pylori infection. European Journal Of Cancer Prevention 2019, Publish Ahead of Print: &na;. PMID: 30272597, DOI: 10.1097/cej.0000000000000471.Peer-Reviewed Original ResearchConceptsH. pylori seropositivityHelicobacter pylori infectionPylori infectionPylori seropositivityPrevalence ratiosStomach cancer Pooling (StoP) ProjectDuration of smokingH. pylori infectionCase-control studyConfidence intervalsSummary odds ratiosIndividual participant dataOdds ratioEgger's testGastric cancerStratified analysisMajor covariatesPooling ProjectGreater prevalenceSmokingH. pyloriSignificant associationPublication biasSeropositivityInfectionSex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project)
Ferro A, Morais S, Pelucchi C, Dierssen-Sotos T, Martín V, López-Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernández-Ramírez RU, López-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Sex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project). European Journal Of Gastroenterology & Hepatology 2019, 31: 593-598. PMID: 30839435, DOI: 10.1097/meg.0000000000001389.Peer-Reviewed Original ResearchConceptsH. pylori infectionHelicobacter pylori infectionPylori infectionPrevalence ratiosOdds ratioGastric atrophyIgG serum antibody titersStomach cancer Pooling (StoP) ProjectPublication biasInfection statusSerum antibody titersConfidence intervalsSummary odds ratiosSerum pepsinogen levelsIndividual participant dataLifetime infectionsMultiplex serologyAntibody titersHistological examinationPooling ProjectPepsinogen levelsOlder controlsInfectionParticipant dataStrong associationEducation and gastric cancer risk—An individual participant data meta‐analysis in the StoP project consortium
Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, Zhang Z, Johnson KC, Palli D, Ferraroni M, Yu G, Galeone C, López‐Carrillo L, Muscat J, Lunet N, Ferro A, Ye W, Plymoth A, Malekzadeh R, Zaridze D, Maximovitch D, Kogevinas M, de Larrea N, Vioque J, Navarrete‐Muñoz E, Tsugane S, Hamada GS, Hidaka A, Pakseresht M, Wolk A, Håkansson N, Hernández‐Ramírez R, López‐Cervantes M, Ward M, Pourfarzi F, Mu L, Kurtz RC, Lagiou A, Lagiou P, Boffetta P, Boccia S, Negri E, La Vecchia C. Education and gastric cancer risk—An individual participant data meta‐analysis in the StoP project consortium. International Journal Of Cancer 2019, 146: 671-681. PMID: 30919464, DOI: 10.1002/ijc.32298.Peer-Reviewed Original ResearchConceptsGastric cancer riskIndividual participant dataOdds ratioCancer riskSocioeconomic positionHighest household income categoryStomach cancer Pooling (StoP) ProjectStudy-specific odds ratiosH. pylori-negative subjectsGC riskParticipant dataPylori-negative subjectsStrong risk factorRandom-effects meta-analytic modelConfidence intervalsPooled odds ratioStrong inverse associationLow socioeconomic positionPublic health interventionsHousehold income categoryNegative subjectsInverse associationRisk factorsPooling ProjectPremature mortalityAssociation of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study
Hernández-Ramírez RU, Qin L, Lin H, Leyden W, Neugebauer RS, Althoff KN, Achenbach CJ, Hessol NA, D'Souza G, Gebo KA, Gill MJ, Grover S, Horberg MA, Li J, Mathews WC, Mayor AM, Park LS, Rabkin CS, Salters K, Justice AC, Moore RD, Engels EA, Silverberg MJ, Dubrow R, AIDS N, Betts A, Brooks J, Freeman A, Van Rompaey S, Burchell A, Yip B, You B, Hogan B, Grasso C, Hogg R, Benson C, Drozd D, Sterling T, Haas D, Humes E, Crane H, Willig J, Eron J, Martin J, Saag M, Jing J, Zhang J, Lindsay J, Hunter-Mellado R, Deeks S, Zhu J, Montaner J, McReynolds J, Gabler K, Buchacz K, Rodriguez B, Thorne J, Margolick J, Anastos K, Jacobson L, Klein M, Kroch A, Morton L, Turner M, Fiellin D, Gange S, Mugavero M, Harrigan P, Rebeiro P, Bosch R, Kirk G, Mayer K, McKaig R, Coburn S, Napravnik S, Kitahata M, Lober W, Lee J. Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study. The Lancet HIV 2019, 6: e240-e249. PMID: 30826282, PMCID: PMC6531288, DOI: 10.1016/s2352-3018(18)30360-6.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaRecent CD4 countCD4 countHIV viraemiaKey independent predictorsViral loadIndependent predictorsNorth American AIDS Cohort CollaborationCNS non-Hodgkin's lymphomaOverall non-Hodgkin lymphomaDiffuse large B-cell lymphomaLarge B-cell lymphomaAssociation of immunosuppressionMulticentre cohort studyNon-Hodgkin lymphoma (NHL) riskAverage viral loadUS Health ResourcesB-cell lymphomaOverall immune functionB cell activationLong-term careCohort CollaborationRecent immunosuppressionAntiretroviral therapyCohort studyCitrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium
Bertuccio P, Alicandro G, Rota M, Pelucchi C, Bonzi R, Galeone C, Bravi F, Johnson KC, Hu J, Palli D, Ferraroni M, López‐Carrillo L, Lunet N, Ferro A, Malekzadeh R, Zaridze D, Maximovitch D, Vioque J, Navarrete‐Munoz E, Pakseresht M, Hernández‐Ramírez R, López‐Cervantes M, Ward M, Pourfarzi F, Tsugane S, Hidaka A, Zhang Z, Kurtz RC, Lagiou P, Lagiou A, Boffetta P, Boccia S, Negri E, La Vecchia C. Citrus fruit intake and gastric cancer: The stomach cancer pooling (StoP) project consortium. International Journal Of Cancer 2019, 144: 2936-2944. PMID: 30521095, DOI: 10.1002/ijc.32046.Peer-Reviewed Original ResearchConceptsCitrus fruit intakeStomach cancer pooling (StoP) project consortiumGastric cancerFruit intakeOdds ratioPrevious cohort studiesServings/weekConfidence intervalsCase-control studyCitrus fruit consumptionGastric cancer riskCohort studyInverse associationRisk factorsProtective effectCitrus fruitsCancer riskHighest thirdNull associationProtective roleLinear mixed effects modelsCancerFruit consumptionFavorable effectMixed effects models
2018
Brief Report
Yanik EL, Hernández-Ramírez RU, Qin L, Lin H, Leyden W, Neugebauer RS, Horberg MA, Moore RD, Mathews WC, Justice AC, Hessol NA, Mayor AM, Gill MJ, Brooks JT, Sun J, Althoff KN, Engels EA, Silverberg MJ, Dubrow R. Brief Report. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 78: 499-504. PMID: 29771785, PMCID: PMC6037538, DOI: 10.1097/qai.0000000000001719.Peer-Reviewed Original ResearchConceptsMelanoma incidenceAntiretroviral therapyGeneral populationMelanoma riskNorth American AIDS Cohort CollaborationRelationship of immunosuppressionWhite general populationHIV RNA levelsStandardized incidence ratiosCutaneous melanoma incidenceUltraviolet B exposureHigher melanoma incidenceHigh UVB exposureCohort CollaborationSkin surveillanceCD4 countHIV RNAImmune dysfunctionIncidence ratiosCox regressionHIV replicationRisk factorsCalendar periodWhite raceClinical care
2017
Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study
Hernández-Ramírez RU, Shiels MS, Dubrow R, Engels EA. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. The Lancet HIV 2017, 4: e495-e504. PMID: 28803888, PMCID: PMC5669995, DOI: 10.1016/s2352-3018(17)30125-x.Peer-Reviewed Original ResearchConceptsStandardised incidence ratiosRegistry linkage studyVirus-related cancersCancer riskGeneral populationCancer RegistryModern antiretroviral therapy (ART) eraAntiretroviral therapy eraPopulation-based HIVUSA general populationCohort of HIVNon-Hodgkin lymphomaDiagnosis of cancerNational Cancer InstituteSIR differenceTherapy eraCancer overallIncident cancerMultivariable adjustmentART exposureIncidence ratiosAIDS onsetCommon cancerLung cancerKaposi's sarcomaAssociation of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada
Dubrow R, Qin L, Lin H, Hernández-Ramírez RU, Neugebauer RS, Leyden W, Althoff KN, Achenbach CJ, Hessol NA, Modur SP, D'Souza G, Bosch RJ, Grover S, Horberg MA, Kitahata MM, Mayor AM, Novak RM, Rabkin CS, Sterling TR, Goedert JJ, Justice AC, Engels EA, Moore RD, Silverberg MJ. Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 75: 382-390. PMID: 28394855, PMCID: PMC5490794, DOI: 10.1097/qai.0000000000001394.Peer-Reviewed Original ResearchConceptsT-cell countsKS riskCD4 countKaposi's sarcomaART useHIV-1 RNA viral loadNorth American AIDS Cohort CollaborationTime-updated Cox regressionCD4 T-cell countKaposi's sarcoma riskAntiretroviral therapy useRNA viral loadRecent CD4 countViral load measuresAssociation of CD4Cohort CollaborationKS etiologyRecent VLVL measuresAntiretroviral therapyHIV diagnosisIndependent predictorsTherapy useViral loadCox regression
2016
Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS
Park LS, Hernández-Ramírez RU, Silverberg MJ, Crothers K, Dubrow R. Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS. AIDS 2016, 30: 273-291. PMID: 26691548, PMCID: PMC4689318, DOI: 10.1097/qad.0000000000000922.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh-risk HPV infectionCancer risk factorsHepatitis B virusHepatitis C virusUS adultsHPV infectionRisk factorsHIV/AIDSPrevalence estimatesHuman papillomavirusAnal high-risk HPV infectionCervical high-risk HPV infectionOral high-risk HPV infectionModifiable cancer risk factorsOverweight/obesity prevalenceConsiderable study heterogeneityChronic HCV infectionOverweight/obesityPrevalence of smokingSummary prevalence estimatesBurden of cancerOncogenic virus infectionWestern high-income countriesAdult PLWHAAlcohol consumption prevalence
2014
Dietary Patterns and Gastric Cancer Risk in Mexico
Denova-Gutiérrez E, Hernández-Ramírez RU, López-Carrillo L. Dietary Patterns and Gastric Cancer Risk in Mexico. Nutrition And Cancer 2014, 66: 369-376. PMID: 24628363, DOI: 10.1080/01635581.2014.884237.Peer-Reviewed Original ResearchConceptsDietary patternsGastric cancerGC riskPopulation-based case-control studyLower GC riskMajor dietary patternsHealthy dietary patternCase-control studyMultiple epidemiological studiesGastric cancer riskConsumption of vegetablesExtreme quintilesHighest quintileLowest quintileCancer riskEpidemiological studiesFood groupsSignificant associationGC casesP-trendIndividual foodsQuintilePattern 1RiskWhite meat
2013
Arsenic Exposure and Calpain-10 Polymorphisms Impair the Function of Pancreatic Beta-Cells in Humans: A Pilot Study of Risk Factors for T2DM
Díaz-Villaseñor A, Cruz L, Cebrián A, Hernández-Ramírez RU, Hiriart M, García-Vargas G, Bassol S, Sordo M, Gandolfi AJ, Klimecki WT, López-Carillo L, Cebrián ME, Ostrosky-Wegman P. Arsenic Exposure and Calpain-10 Polymorphisms Impair the Function of Pancreatic Beta-Cells in Humans: A Pilot Study of Risk Factors for T2DM. PLOS ONE 2013, 8: e51642. PMID: 23349674, PMCID: PMC3551951, DOI: 10.1371/journal.pone.0051642.Peer-Reviewed Original ResearchConceptsBeta-cell functionLower beta-cell functionSNP-43Risk factorsInsulin sensitivitySNP-44IAs exposureSingle nucleotide polymorphismsChronic exposureCAPN-10Type 2 diabetes mellitusOutcomes of T2DMCalpain-10 polymorphismsGenetic risk factorsPancreatic beta cellsAction of insulinCalpain-10 geneDiabetes mellitusInverse associationInsulin secretionT2DMBeta cellsRisk genotypesArsenic exposurePilot study
2012
Capsaicin consumption, Helicobacter pylori CagA status and IL1B-31C>T genotypes: A host and environment interaction in gastric cancer
López-Carrillo L, Camargo MC, Schneider BG, Sicinschi LA, Hernández-Ramírez RU, Correa P, Cebrian ME. Capsaicin consumption, Helicobacter pylori CagA status and IL1B-31C>T genotypes: A host and environment interaction in gastric cancer. Food And Chemical Toxicology 2012, 50: 2118-2122. PMID: 22414649, PMCID: PMC3636974, DOI: 10.1016/j.fct.2012.02.043.Peer-Reviewed Original ResearchConceptsGastric cancerCagA statusHelicobacter pylori CagA statusGC riskH. pylori CagA statusConsumption of capsaicinFood frequency questionnaireUnconditional logistic regressionHigh-risk individualsVirulent H. pyloriFrequency questionnaireClinical controlGC patientsRisk individualsT genotypeGene-environment interactionsMortality ratePotential interactionsIL1B -31CH. pyloriSusceptible individualsMortality trendsCapsaicin consumptionLogistic regressionTaqMan assays
2011
Validity and reproducibility of a food frequency questionnaire to estimate folate intake in a Mexican population.
Galván-Portillo M, Torres-Sánchez L, Hernández-Ramírez RU, Anaya-Loyola MA. Validity and reproducibility of a food frequency questionnaire to estimate folate intake in a Mexican population. Salud Pública De México 2011, 53: 237-46. PMID: 21829889, DOI: 10.1590/s0036-36342011000300008.Peer-Reviewed Original Research
2009
Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City
Hernández‐Ramírez R, Galván‐Portillo M, Ward MH, Agudo A, González CA, Oñate‐Ocaña L, Herrera‐Goepfert R, Palma‐Coca O, López‐Carrillo L. Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City. International Journal Of Cancer 2009, 125: 1424-1430. PMID: 19449378, PMCID: PMC2787087, DOI: 10.1002/ijc.24454.Peer-Reviewed Original ResearchConceptsHigh intakeGastric cancerGC riskN-nitroso compoundsPopulation-based case-control studyFood frequency questionnaireIntake of polyphenolsCase-control studyGastric cancer riskPotent animal carcinogensFrequency questionnaireDietary intakeNitrite intakeLow intakeProtective effectCancer riskDietary polyphenolsEndogenous nitrosationTotal nitriteDiffuse typeCombined consumptionPotential human carcinogensGC casesNOC precursorsIntakeGastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers
Galván-Portillo MV, Cantoral A, Oñate-Ocaña LF, Chen J, Herrera-Goepfert R, Torres-Sanchez L, Hernandez-Ramirez RU, Palma-Coca O, López-Carrillo L. Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers. European Journal Of Nutrition 2009, 48: 269-276. PMID: 19288150, DOI: 10.1007/s00394-009-0010-5.Peer-Reviewed Original ResearchConceptsOne-carbon metabolismDNA methylationMTHFR 677 TT genotypeImportant epigenetic processDietary intakeTT genotypePopulation-based case-control studyGC riskMethylenetetrahydrofolate reductaseFood frequency questionnaireTranscriptional controlHuman genomeCase-control studySex-matched controlsEpigenetic processesPCR-RFLP analysisMTHFR 677 CCMTHFR 677 CBorderline of significanceKey enzymeIntake of nutrientsMetabolic pathwaysCancer initiationMethyl-donor nutrientsMethylation