Philip Armstrong
Associate Clinical Professor of Epidemiology (Microbial Diseases)About
Titles
Associate Clinical Professor of Epidemiology (Microbial Diseases)
Biography
Dr. Armstrong earned his undergraduate degree in biology at the University of California, Santa Cruz and his doctoral degree at the Harvard School of Public Health. He joined the faculty at the Connecticut Agricultural Experiment Station in 2004 to participate in the statewide mosquito surveillance program and develop his own research program on arthropod-borne viruses (arboviruses). Current research focuses on the molecular evolution and ecology of mosquito- and tick-borne viruses transmitted in the northeastern U.S., including eastern equine encephalitis virus, West Nile virus, and Powassan virus.Genetic relationships of these viruses are compared to track the origin, spread, and long-term persistence of strains involved in disease outbreaks. Other projects in his laboratory evaluate the role of different mosquito species to serve as vectors of arboviruses by determining their vector competence, host-feeding, and infection patterns in nature. He also directs the Connecticut Mosquito and Arbovirus Surveillance Program that monitors mosquito populations and arbovirus activity at 91 locations statewide.
Appointments
Epidemiology of Microbial Diseases
Associate Professor AdjunctPrimary
Other Departments & Organizations
Research
Research at a Glance
Yale Co-Authors
John Anderson, PhD
Theodore Andreadis, PhD
Douglas Brackney
Durland Fish, PhD
Goudarz Molaei
Publications
2024
Multiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera
Ferdous Z, Dieme C, Sproch H, Kramer L, Ciota A, Brackney D, Armstrong P. Multiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera. Parasites & Vectors 2024, 17: 432. PMID: 39427222, PMCID: PMC11490111, DOI: 10.1186/s13071-024-06531-y.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAedes aegyptiMidgut infection ratesMultiple bloodmealsVector competence of Aedes aegyptiVirus vectorsLaboratory vector competence studiesVector competence studiesMosquito generaFeeding regimenBiting midgesCulex quinquefasciatusPost-infectionOropouche virusWest Nile virusBloodmealVirus disseminationVector competenceEscape barrierFeeding behaviorDissemination of arbovirusesAedes albopictus mosquitoesAedes triseriatusAedesFemale mosquitoesNile virusHost-Feeding Behavior of Mosquitoes in the Florida Everglades
Anderson J, Molaei G, Fish D, Armstrong P, Khalil N, Brudner S, Misencik M, Bransfield A, Olson M, Andreadis T. Host-Feeding Behavior of Mosquitoes in the Florida Everglades. Vector-Borne And Zoonotic Diseases 2024, 24: 520-531. PMID: 38648543, DOI: 10.1089/vbz.2023.0072.Peer-Reviewed Original ResearchAltmetricConceptsHispid cotton ratsWest Nile virusWading birdsAmerican alligatorMosquito speciesSusceptibility to WNVCulex nigripalpus</i>,Blood meals of mosquitoesFlorida EvergladesBlood mealMarsh rabbitWhite-tailed deerIndustrial sitesBlood-fed specimensEverglades virusSpecies of rodentsHost speciesBlood-fed mosquitoesAvian hostsTransmit West Nile virusBehavior of mosquitoesFrequent hostsPCR assayTensaw virusHost feeding behaviorInvestigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics
Johnson R, Stopard I, Byrne H, Armstrong P, Brackney D, Lambert B. Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics. PLOS Pathogens 2024, 20: e1011975. PMID: 38557892, PMCID: PMC11008821, DOI: 10.1371/journal.ppat.1011975.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBasal lamina layersInfection dynamicsYellow fever virusEpidemics of severe diseaseMidgut escape barrierDengue virusVirus population dynamicsAmount of virusEstablishment of infectionDose-dependentlyMosquito feeding behaviorDEN virusesExtrinsic incubation periodFever virusMidgut epitheliumBlood feedingFeeding eventsMidgutViral infection dynamicsZika virusAedes aegyptiCourse of infectionEscape barrierAedes albopictusIncubation periodField Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida.
Armstrong P, Anderson J, Sharma R, Misencik M, Bransfield A, Vossbrinck C, Brackney D. Field Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida. American Journal Of Tropical Medicine And Hygiene 2024, 110: 968-970. PMID: 38531101, PMCID: PMC11066360, DOI: 10.4269/ajtmh.23-0799.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCulex quinquefasciatusMultiple mouse tissuesVector competenceDisseminated infectionNucleotide identityTexas isolatesL segmentField isolatesS segmentFlorida strainBlood mealMidgut infectionDisease signsMouse tissuesLaboratory trialsCulex erraticusIntradermal inoculationAedes aegyptiQuinquefasciatusCulex mosquitoesCulexIsolatesSouthern FloridaSuckling miceVirus transmission
2005
Isolations of Potosi Virus from Mosquitoes (Diptera: Culicidae) Collected in Connecticut
Armstrong P, Andreadis T, Anderson J, Main A. Isolations of Potosi Virus from Mosquitoes (Diptera: Culicidae) Collected in Connecticut. Journal Of Medical Entomology 2005, 42: 875-881. PMID: 16363172, DOI: 10.1093/jmedent/42.5.875.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsBase SequenceChlorocebus aethiopsCluster AnalysisConnecticutCulicidaeDemographyDNA PrimersEnzyme-Linked Immunosorbent AssayMolecular Sequence DataOrthobunyavirusPhylogenyReverse Transcriptase Polymerase Chain ReactionSequence Analysis, DNASpecies SpecificityVero CellsViral Envelope ProteinsConceptsPotosi virusTrivittatus virusNortheastern United StatesMosquito speciesReverse transcription-polymerase chain reactionIndigenous strainsEncoded amino acid sequenceAnopheles punctipennisStatewide surveillance programAedes vexansAedes albopictusAmino acid sequenceRestriction enzyme analysisEnzyme-linked immunosorbent assayCVVViral isolatesIsolation rateCross-neutralizationAcid sequenceMosquitoesViral isolation rateAedesJamestown CanyonMolecular assaysTranscription-polymerase chain reaction