2018
Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series
Jia N, Zheng YC, Jiang JF, Jiang RR, Jiang BG, Wei R, Liu HB, Huo QB, Sun Y, Chu YL, Fan H, Chang QC, Yao NN, Zhang WH, Wang H, Guo DH, Fu X, Wang YW, Krause PJ, Song JL, Cao WC. Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series. Clinical Infectious Diseases 2018, 67: 1110-1119. PMID: 29538646, DOI: 10.1093/cid/ciy212.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionAsymptomatic infectionTick biteHuman babesiosisInfection 9 monthsRecent tick biteViral-like illnessCommon clinical manifestationsHaemaphysalis concinna ticksCase seriesInitial diagnosisClinical manifestationsOvarian tumorsModerate symptomsUS CentersBlood supplySevere diseaseHealthy residentsHealth problemsDisease controlInfectionChain reactionGenetic sequencingPatientsFurther investigation
2003
Successful Treatment of Human Granulocytic Ehrlichiosis in Children Using Rifampin
Krause PJ, Corrow CL, Bakken JS. Successful Treatment of Human Granulocytic Ehrlichiosis in Children Using Rifampin. Pediatrics 2003, 112: e252-e253. PMID: 12949322, DOI: 10.1542/peds.112.3.e252.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisYears of ageSuccessful treatmentGranulocytic ehrlichiosisTick-borne infectious diseaseFlu-like illnessTreatment of choiceHospital admissionClinical featuresSerious infectionsInfectious diseasesPhagocytophilum infectionRifampinAnaplasma phagocytophilumPermanent stainingChildrenInfectionTreatmentEhrlichiosisAgeYearsAdmissionIllnessDiseaseDoxycyclineIncreasing health burden of human babesiosis in endemic sites.
KRAUSE PJ, McKay K, Gadbaw J, Christianson D, Closter L, Lepore T, TELFORD SR, Sikand V, Ryan R, Persing D, RADOLF JD, Spielman A, _ _. Increasing health burden of human babesiosis in endemic sites. American Journal Of Tropical Medicine And Hygiene 2003, 68: 431-6. PMID: 12875292, DOI: 10.4269/ajtmh.2003.68.431.Peer-Reviewed Original ResearchConceptsYears of ageEndemic sitesCommunity-based serosurveysClinical spectrumHealth burdenPeople 20Borrelial infectionHuman infectionsBabesial infectionMore older adultsBabesia microtiBabesial antigensOlder adultsHuman babesiosisYoung adultsInfectionBorrelia burgdorferiIncidenceThree-fourthsAdultsAgePrudence IslandSeroprevalenceSerosurveyHospital
2002
Ehrlichiosis in children
Lantos P, Krause PJ. Ehrlichiosis in children. Seminars In Pediatric Infectious Diseases 2002, 13: 249-256. PMID: 12491230, DOI: 10.1053/spid.2002.127200.Peer-Reviewed Original ResearchBabesiosis: similar to malaria but different.
Lantos PM, Krause PJ. Babesiosis: similar to malaria but different. Pediatric Annals 2002, 31: 192-7. PMID: 11905293, DOI: 10.3928/0090-4481-20020301-10.Peer-Reviewed Original Research
2001
Safety and Immunogenicity of a Recombinant Borrelia burgdorferi Outer Surface Protein A Vaccine Against Lyme Disease in Healthy Children and Adolescents: A Randomized Controlled Trial
Sikand V, Halsey N, Krause P, Sood S, Geller R, Van Hoecke C, Buscarino C, Parenti D. Safety and Immunogenicity of a Recombinant Borrelia burgdorferi Outer Surface Protein A Vaccine Against Lyme Disease in Healthy Children and Adolescents: A Randomized Controlled Trial. Pediatrics 2001, 108: 123-128. PMID: 11433064, DOI: 10.1542/peds.108.1.123.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntigens, SurfaceArthralgiaBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupChildChild, PreschoolEdemaErythemaExanthemaFatigueFemaleFeverHeadacheHumansImmunoglobulin GIncidenceInjectionsLipoproteinsLyme DiseaseLyme Disease VaccinesMalePainSeverity of Illness IndexTime FactorsUnited StatesConceptsLocal injection site reactionsInjection site reactionsYears of ageMonth 13LD vaccineVaccine recipientsSite reactionsHealthy childrenEfficacy studiesChildren 4Placebo-controlled clinical trialUnsolicited adverse eventsFlu-like symptomsLyme disease vaccineHigher immune responseLyme endemic areasOuter Surface ProteinsAdolescents 15 yearsIgG GMTPlacebo recipientsReactogenicity dataAdverse eventsControlled TrialsMonth 6Immunogenicity data
1999
Southern Extension of the Range of Human Babesiosis in the Eastern United States
Eskow E, Krause P, Spielman A, Freeman K, Aslanzadeh J. Southern Extension of the Range of Human Babesiosis in the Eastern United States. Journal Of Clinical Microbiology 1999, 37: 2051-2052. PMID: 10325378, PMCID: PMC85028, DOI: 10.1128/jcm.37.6.2051-2052.1999.Peer-Reviewed Original ResearchConceptsMicroti infectionBlood samplesB. microti antibodiesSerial blood samplesBabesia microti infectionB. microti infectionCollected blood samplesMicroti antibodiesAcute babesiosisImmunofluorescent antibodyHuman B. microti infectionBabesial antigensHuman babesiosisB. microtiInfectionBabesiosisAntibodiesPCR techniqueUnited StatesLocal acquisitionResidentsPatientsSymptomsAntigenBlood
1984
Occurrence of Clostridium difficile toxin-associated gastroenteritis following antibiotic therapy for otitis media in young children
HYAMS J, FEDER H, KRAUSE P, FRICK J, MCLAUGHLIN J, FURTH T, HINE P. Occurrence of Clostridium difficile toxin-associated gastroenteritis following antibiotic therapy for otitis media in young children. The Pediatric Infectious Disease Journal 1984, 3: 433-436. PMID: 6333674, DOI: 10.1097/00006454-198409000-00009.Peer-Reviewed Original ResearchConceptsToxin-positive stoolsOtitis mediaAntibiotic therapyAcute otitis mediaPathogenesis of diarrheaIncidence of diarrheaYoung childrenClostridium difficile toxinProspective studyDifficile toxinDiarrheaC. difficileOlder childrenFurther studiesPatientsStoolTherapyChildrenAge sixAge threeOutpatientsPathogenesisYearsGastroenteritisIncidence
1982
Lymph node biopsy for early diagnosis in Kawasaki disease
Giesker D, Krause P, Pastuszak W, Hine P, Forouhar F. Lymph node biopsy for early diagnosis in Kawasaki disease. The American Journal Of Surgical Pathology 1982, 6: 493-502. PMID: 7149090, DOI: 10.1097/00000478-198209000-00001.Peer-Reviewed Original ResearchConceptsKawasaki diseaseMucocutaneous lymph node syndromeAcute exanthematous illnessAcute pathologic changesLymph node syndromeLymph node biopsyEarly presumptive diagnosisAntithrombotic therapyCervical lymphNode biopsyPrompt institutionAcute phaseExanthematous illnessUnknown etiologyClinical criteriaHistopathologic findingsPresumptive diagnosisClinical signsPathologic changesEarly diagnosisPathologic alterationsPathologic literatureRecent marked increaseEtiologic agentBiopsyAbnormalities of neutrophil adherence in newborns.
Krause P, Maderazo E, Scroggs M. Abnormalities of neutrophil adherence in newborns. Pediatrics 1982, 69: 184-7. PMID: 7058092, DOI: 10.1542/peds.69.2.184.Peer-Reviewed Original ResearchConceptsPMN adherenceNeutrophil adherencePolymorphonuclear neutrophil (PMN) adherenceHealthy term newbornsSerious bacterial infectionsSusceptibility of neonatesTerm newbornsNeonatal PMNNeonatal serumNylon woolAdult serumHumoral inhibitorAdult PMNBacterial infectionsGlass adherenceNormal childrenGood healthAdherenceGreater reductionPMNNewbornsSerumCellular defectsAdultsChildren