2021
The Global Emergence of Human Babesiosis
Kumar A, O’Bryan J, Krause PJ. The Global Emergence of Human Babesiosis. Pathogens 2021, 10: 1447. PMID: 34832603, PMCID: PMC8623124, DOI: 10.3390/pathogens10111447.Peer-Reviewed Original ResearchHuman babesiosisPrimary clinical characteristicsEndemic diseaseGlobal health burdenHard-bodied ticksMode of transmissionFulminant casesTick-borne diseaseClinical characteristicsBlood transfusionDisease locationHealth burdenOrgan transplantationEpidemiologic toolIntraerythrocytic protozoaDiseaseBabesiosisInfectionLike agentsGlobal emergenceHuman pathogensUnited StatesBabesiaWide spectrumPredominant speciesBabesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis
Puri A, Bajpai S, Meredith S, Aravind L, Krause PJ, Kumar S. Babesia microti: Pathogen Genomics, Genetic Variability, Immunodominant Antigens, and Pathogenesis. Frontiers In Microbiology 2021, 12: 697669. PMID: 34539601, PMCID: PMC8446681, DOI: 10.3389/fmicb.2021.697669.Peer-Reviewed Original ResearchPolymerase chain reactionPerinatal transmissionBlood transfusionModerate diseaseMost infectionsOrgan transplantationImmune evasionBlood smearsImmunodominant antigensHuman babesiosisInfection severityPathogenesisChain reactionPotential roleCell surface proteinsDiseaseDiagnosisHuman diseasesPathogen genomicsBabesiosisIxodid ticksPhylum ApicomplexaTransfusionTransplantationHumans
2019
Persistence of Babesia microti Infection in Humans
Bloch EM, Kumar S, Krause PJ. Persistence of Babesia microti Infection in Humans. Pathogens 2019, 8: 102. PMID: 31319461, PMCID: PMC6789900, DOI: 10.3390/pathogens8030102.Peer-Reviewed Original ResearchTransfusion-transmitted babesiosisBabesia microti infectionBlood donor screeningImmune evasive strategiesPeripheral blood smearFifth of casesHost immune mechanismsNovel therapeutic measuresNovel preventive approachesHIV/AIDSTick-borne diseaseRed blood cellsSevere complicationsAnti-parasitic drugsBlood transfusionImmunocompetent individualsImmunosuppressive drugsDonor screeningMicroti infectionImmune mechanismsBlood donorsHealth burdenImmunoglobulin preparationsNew anti-parasitic drugsTherapeutic measuresHuman babesiosis
Krause PJ. Human babesiosis. International Journal For Parasitology 2019, 49: 165-174. PMID: 30690090, DOI: 10.1016/j.ijpara.2018.11.007.Peer-Reviewed Original ResearchConceptsBurden of infectionSignificant health burdenNon-endemic areasTick-borne diseaseThin blood smearsBlood transfusionExchange transfusionHealth burdenSevere casesBlood smearsHuman babesiosisIntraerythrocytic parasitesTransfusionInfectionBabesiosisBurdenProtective measuresBabesia DNAClindamycinAzithromycinAtovaquoneDiseaseSmearsDiagnosis
2018
BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection
Thekkiniath J, Mootien S, Lawres L, Perrin BA, Gewirtz M, Krause PJ, Williams S, Doggett J, Ledizet M, Mamoun C. BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00067-18. PMID: 30093394, PMCID: PMC6156295, DOI: 10.1128/jcm.00067-18.Peer-Reviewed Original ResearchConceptsHuman babesiosisBabesia microti infectionCapture enzyme-linked immunosorbent assayAntigen capture enzyme-linked immunosorbent assayAntigen capture assayEnzyme-linked immunosorbent assayZoonotic infectious diseaseAcute infectionBlood transfusionAsymptomatic infectionMicroti infectionReal-time PCRBlood supplyAnimal reservoir hostsDonor bloodEpidemiological surveyHuman patientsImmune systemSerological assaysImmunodominant antigensInfectionInfectious diseasesIntraerythrocytic protozoan parasitePatientsImmunosorbent assay
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycinBabesiosis
Vannier EG, Diuk-Wasser MA, Mamoun C, Krause PJ. Babesiosis. Infectious Disease Clinics Of North America 2015, 29: 357-370. PMID: 25999229, PMCID: PMC4458703, DOI: 10.1016/j.idc.2015.02.008.Peer-Reviewed Original ResearchHuman babesiosis
Chen T, Mamoun C, Krause P. Human babesiosis. 2015, 1295-1301. DOI: 10.1017/cbo9781139855952.226.Peer-Reviewed Original ResearchHuman babesiosisB. microtiB. microti infectionHard-bodied ticksClustering of casesHuman granulocytic anaplasmosisAcute illnessRenal failureBlood transfusionMicroti infectionCommon causeBabesia duncaniEndemic areasEtiologic agentHuman infectionsHuman B. microti infectionIntraerythrocytic protozoaLyme diseaseBabesia microtiBabesia speciesDiseaseGranulocytic anaplasmosisBabesia infectionIntraerythrocytic parasitesInfection
2013
Chapter 14 Neurological manifestations of human babesiosis
Usmani-Brown S, Halperin JJ, Krause PJ. Chapter 14 Neurological manifestations of human babesiosis. Handbook Of Clinical Neurology 2013, 114: 199-203. PMID: 23829910, DOI: 10.1016/b978-0-444-53490-3.00014-5.Peer-Reviewed Original ResearchConceptsLevel of consciousnessRare complicationBlood transfusionNeurological manifestationsCommon symptomsNeurological dysfunctionFatal diseaseInfectious diseasesIntraerythrocytic protozoaHuman babesiosisDiseaseBabesiosisIxodid ticksTransfusionComplicationsHeadacheDysfunctionLethargyPathogenesisSymptoms
2008
Human Babesiosis
Chen T, Krause P. Human Babesiosis. 2008, 1381-1388. DOI: 10.1017/cbo9780511722240.200.Peer-Reviewed Original ResearchHuman babesiosisB. microtiBabesia speciesB. microti infectionHard-bodied ticksClustering of casesHuman granulocytic anaplasmosisEastern North AmericaAcute illnessBlood transfusionRenal failureMicroti infectionCommon causeBabesia duncaniEndemic areasEtiologic agentHuman B. microti infectionBabesial infectionIntraerythrocytic protozoaBabesia microtiLyme diseaseDiseaseGranulocytic anaplasmosisIntraerythrocytic parasitesNorth America
2000
Serological Expression Cloning of Novel Immunoreactive Antigens of Babesia microti
Lodes M, Houghton R, Bruinsma E, Mohamath R, Reynolds L, Benson D, Krause P, Reed S, Persing D. Serological Expression Cloning of Novel Immunoreactive Antigens of Babesia microti. Infection And Immunity 2000, 68: 2783-2790. PMID: 10768973, PMCID: PMC97488, DOI: 10.1128/iai.68.5.2783-2790.2000.Peer-Reviewed Original ResearchConceptsRelated antigensBabesia microtiSerological expression cloningB. microtiHumoral immune responseB. microti infectionClass of antigensSporozoite surface antigenPatient serum poolsWestern blot analysisBlood transfusionMicroti infectionImmune responseSurface antigenImmunodominant antigensAntigenHuman babesiosisMolecular testsGenomic expression libraryPlasmodium spCausative agentSerum poolsImmunoreactive antigensBlot analysisMicroti