2008
Human Babesiosis
Vannier E, Gewurz BE, Krause PJ. Human Babesiosis. Infectious Disease Clinics Of North America 2008, 22: 469-488. PMID: 18755385, PMCID: PMC3998201, DOI: 10.1016/j.idc.2008.03.010.Peer-Reviewed Original ResearchConceptsBabesial infectionHuman babesiosisCombination of atovaquoneTreatment of choiceSpecific laboratory diagnosisModerate illnessExchange transfusionPolymerase chain reactionSevere diseaseLaboratory diagnosisMorphologic examinationBlood smearsProtozoal parasitesInfectionChain reactionBabesial DNABabesiosisIntraerythrocytic infectionUnited StatesIxodid ticksTransfusionUpper midwestern regionsClindamycinSerologyAzithromycinHuman Babesiosis
Chen T, Krause P. Human Babesiosis. 2008, 1381-1388. DOI: 10.1017/cbo9780511722240.200.Peer-Reviewed Original ResearchHuman babesiosisB. microtiBabesia speciesB. microti infectionHard-bodied ticksClustering of casesHuman granulocytic anaplasmosisEastern North AmericaAcute illnessBlood transfusionRenal failureMicroti infectionCommon causeBabesia duncaniEndemic areasEtiologic agentHuman B. microti infectionBabesial infectionIntraerythrocytic protozoaBabesia microtiLyme diseaseDiseaseGranulocytic anaplasmosisIntraerythrocytic parasitesNorth America
2003
Increasing health burden of human babesiosis in endemic sites.
KRAUSE PJ, McKay K, Gadbaw J, Christianson D, Closter L, Lepore T, TELFORD SR, Sikand V, Ryan R, Persing D, RADOLF JD, Spielman A, _ _. Increasing health burden of human babesiosis in endemic sites. American Journal Of Tropical Medicine And Hygiene 2003, 68: 431-6. PMID: 12875292, DOI: 10.4269/ajtmh.2003.68.431.Peer-Reviewed Original ResearchConceptsYears of ageEndemic sitesCommunity-based serosurveysClinical spectrumHealth burdenPeople 20Borrelial infectionHuman infectionsBabesial infectionMore older adultsBabesia microtiBabesial antigensOlder adultsHuman babesiosisYoung adultsInfectionBorrelia burgdorferiIncidenceThree-fourthsAdultsAgePrudence IslandSeroprevalenceSerosurveyHospitalBabesiosis Diagnosis and Treatment
Krause PJ. Babesiosis Diagnosis and Treatment. Vector-Borne And Zoonotic Diseases 2003, 3: 45-51. PMID: 12804380, DOI: 10.1089/153036603765627451.Peer-Reviewed Original ResearchConceptsBlood smearsThin blood smearsPolymerase chain reactionRobust antibody responseLife-saving therapyUseful screening testPulmonary compromiseSubclinical illnessSerologic testingClinical manifestationsExchange transfusionAntibody responseAdverse reactionsHigh parasitemiaConclusive diagnosisSevere diseaseAccurate diagnosisScreening testBabesial infectionBabesia microtiHuman babesiosisInfectionSignificant hemolysisDiseaseSmears
1998
Persistent Parasitemia after Acute Babesiosis
Krause P, Spielman A, Telford S, Sikand V, McKay K, Christianson D, Pollack R, Brassard P, Magera J, Ryan R, Persing D. Persistent Parasitemia after Acute Babesiosis. New England Journal Of Medicine 1998, 339: 160-165. PMID: 9664092, DOI: 10.1056/nejm199807163390304.Peer-Reviewed Original ResearchConceptsDuration of parasitemiaSpecific therapySide effectsInfected peopleCommunity-based studyEpisodes of illnessProtozoan Babesia microtiBabesial DNASymptoms of babesiosisRecrudescent diseaseQuinine therapyThin blood smearsPersistent parasitemiaInfected subjectsSerologic testsIll subjectsSpecific symptomsAcute babesiosisMore monthsParasitemiaBlood smearsBabesial infectionTherapyBabesia microtiSymptoms
1996
Concurrent Lyme Disease and Babesiosis: Evidence for Increased Severity and Duration of Illness
Krause P, Telford S, Spielman A, Sikand V, Ryan R, Christianson D, Burke G, Brassard P, Pollack R, Peck J, Persing D. Concurrent Lyme Disease and Babesiosis: Evidence for Increased Severity and Duration of Illness. JAMA 1996, 275: 1657-1660. DOI: 10.1001/jama.1996.03530450047031.Peer-Reviewed Original ResearchConcurrent Lyme diseaseDuration of illnessLyme diseaseClinic-based cohort studyBabesial infectionDuration of symptomsNumber of symptomsCoinfected PatientsSpirochete antigenCohort studyIncreased SeverityPatientsMore symptomsMedical clinicsPersistent episodesSymptomsDiseaseSpirochetal DNAEmotional labilityInfectionBabesial antigensIllnessBabesiosisClinicAntigen