2022
Urinary phenol concentrations and fecundability and early pregnancy loss
Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N, Johnson C, Jukic A. Urinary phenol concentrations and fecundability and early pregnancy loss. Human Reproduction 2022, 38: 139-155. PMID: 36346334, PMCID: PMC10089295, DOI: 10.1093/humrep/deac230.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossPregnancy lossUrinary phenol concentrationsIntraclass correlation coefficientMenstrual cycleNational InstituteDaily first-morning urine specimensPhenol exposureEnvironmental Health SciencesFirst morning urine specimensLogistic regressionSTUDY FUNDING/COMPETINGMultivariable logistic regressionPARTICIPANTS/MATERIALSROLE OF CHANCEIntramural Research ProgramClinical miscarriageProspective cohortIncreased oddsLive birthsEpidemiologic studiesUrine specimensHealth SciencesEndocrine-disrupting potentialReproductive function
2018
Prioritization of reproductive toxicants in unconventional oil and gas operations using a multi-country regulatory data-driven hazard assessment
Inayat-Hussain SH, Fukumura M, Aziz A, Jin CM, Jin LW, Garcia-Milian R, Vasiliou V, Deziel NC. Prioritization of reproductive toxicants in unconventional oil and gas operations using a multi-country regulatory data-driven hazard assessment. Environment International 2018, 117: 348-358. PMID: 29793188, DOI: 10.1016/j.envint.2018.05.010.Peer-Reviewed Original ResearchConceptsReproductive toxicantsUOG chemicalsReproductive toxicityStringent classificationAdverse birth outcomesPotential etiologic agentsGerm cell mutagenicityMultiple adverse effectsPotential public health riskBirth outcomesRegulatory agency databasesEpidemiologic studiesEtiologic agentReproductive healthScoring systemPublic health riskSafe alternativeAdverse effectsHazard identificationDevelopmental toxicantsHazard scoreCytoscape analysisExposure assessmentCancerHealth risks
2012
Comparability and repeatability of methods for estimating the dietary intake of the heterocyclic amine contaminant 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP)
Deziel NC, Buckley TJ, Sinha R, Abubaker S, Platz EA, Strickland PT. Comparability and repeatability of methods for estimating the dietary intake of the heterocyclic amine contaminant 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP). Food Additives & Contaminants Part A 2012, 29: 1202-1211. PMID: 22571725, PMCID: PMC3412362, DOI: 10.1080/19440049.2012.682657.Peer-Reviewed Original ResearchConceptsIntraclass correlation coefficientPhIP intakeUrinary PhIPDietary Heterocyclic Amine ExposureHeterocyclic amine exposureFull study populationSubject variabilityExposure assessment methodsBiomarker-based approachDiary-based estimatesSpearman correlation coefficientDietary intakeStudy populationEpidemiologic studiesLong-term exposureHCA 2Intake estimatesAmine exposurePhIP concentrationIntakePhIPInconsistent riskTerm exposureAssessment toolDiary collection