2001
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches
Spahn T, Fontana A, Faria A, Slavin A, Eugster H, Zhang X, Koni P, Ruddle N, Flavell R, Rennert P, Weiner H. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. European Journal Of Immunology 2001, 31: 1278-1287. PMID: 11298355, DOI: 10.1002/1521-4141(200104)31:4<1278::aid-immu1278>3.0.co;2-a.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAntibodiesDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFecesGene DeletionHypersensitivity, DelayedImmune ToleranceImmunity, MucosalImmunoglobulin AInterferon-gammaInterleukin-2Lymph NodesLymphotoxin-alphaMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutOvalbuminPeyer's PatchesSignal TransductionTumor Necrosis Factor-alphaConceptsGut-associated lymphoid tissueMesenteric lymph nodesOral toleranceLow-dose oral toleranceDelayed-type hypersensitivity responseFecal IgA productionLTbeta-/- miceOral tolerance inductionLamina propria lymphocytesIntact immune systemCellular immune responsesPeripheral lymphoid organsIFN-gamma productionTumor necrosis factor familyProcessing of antigensNecrosis factor familySystemic hyporesponsivenessLymph nodesHypersensitivity responseTolerance inductionIgA productionIntraperitoneal administrationLymphoid organsLymphoid tissuePeyer's patches
1972
Approaches to the Quantitative Analysis of Delayed Hypersensitivity
Ruddle N. Approaches to the Quantitative Analysis of Delayed Hypersensitivity. Current Topics In Microbiology And Immunology 1972, 57: 75-110. PMID: 4554356, DOI: 10.1007/978-3-642-65297-4_3.Peer-Reviewed Original Research
1971
Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro.
Ellison G, Waksman B, Ruddle N. Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro. Neurology 1971, 21: 778-82. PMID: 5106293, DOI: 10.1212/wnl.21.8.778.Peer-Reviewed Original Research
1968
CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1237-1254. PMID: 4176937, PMCID: PMC2138572, DOI: 10.1084/jem.128.6.1237.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensBacterial ProteinsCattleCulture TechniquesFibroblastsGamma-GlobulinsHypersensitivity, DelayedLymphocytesOvalbuminRatsTuberculinConceptsLymph node cellsTarget cell ratiosDelayed hypersensitivityNode cellsSoluble antigenSpecific antigenBovine gammaglobulinProgressive destructionCell ratioAntigen concentrationTarget cellsLymphocytesAntigenHypersensitivityCell enumerationEgg albuminCellsHrRat embryo fibroblastsTissue cultureLymphGammaglobulinRatsEmbryo fibroblastsCYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1255-1265. PMID: 4235040, PMCID: PMC2138586, DOI: 10.1084/jem.128.6.1255.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensArthus ReactionBacterial ProteinsCulture TechniquesFibroblastsHumansHypersensitivity, DelayedLymphocytesOvalbuminRatsSerum AlbuminSkin TestsTuberculinConceptsLymph node cellsNode cellsSensitized lymph node cellsArthus reactivityLewis ratsBN ratsSkin reactivityAllogeneic fibroblastsDelayed hypersensitivitySoluble antigenSpecific antigenHomologous conjugateCytotoxic effectsRatsAntigenHypersensitivityProtein carrierHuman serum albuminCellsAnimalsRat embryo fibroblastsSpecific damageSerum albuminFibroblastsConjugatesCYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1267-1279. PMID: 5693925, PMCID: PMC2138574, DOI: 10.1084/jem.128.6.1267.Peer-Reviewed Original ResearchMeSH KeywordsAcid PhosphataseAnimalsBacterial ProteinsCulture TechniquesFibroblastsHistocytochemistryHypersensitivity, DelayedLymphocytesRatsTime FactorsTuberculinConceptsLymph node cellsNode cellsNormal lymph node cellsReaction of lymphocytesPresence of PPDDelayed hypersensitivitySoluble antigenSpecific antigenCytopathic effectAntigenPreincubation studiesTarget fibroblastsSensitized cellsMarked increaseAcid phosphatase contentLymphocytesSupernatant fluidCytotoxic activityPPDFibroblastsCellsPhosphatase contentHrRat embryo fibroblastsLymph
1967
Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity
Ruddle N, Waksman B. Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity. Science 1967, 157: 1060-1062. PMID: 6036235, DOI: 10.1126/science.157.3792.1060.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensCulture TechniquesFibroblastsHypersensitivity, DelayedLymph NodesLymphocytesMaleOvalbuminRatsTuberculin