2016
The lymphotoxin β receptor is a potential therapeutic target in renal inflammation
Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M, Segerer S. The lymphotoxin β receptor is a potential therapeutic target in renal inflammation. Kidney International 2016, 89: 113-126. PMID: 26398497, DOI: 10.1038/ki.2015.280.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCell LineChemokinesDisease Models, AnimalEpithelial CellsFemaleGlomerulonephritis, IGAHumansImmunoglobulinsKidney GlomerulusKidney TubulesLigandsLupus NephritisLymphocytesLymphotoxin beta ReceptorLymphotoxin-alphaLymphotoxin-betaMaleMesangial CellsMiceMiddle AgedRNA, MessengerSignal TransductionTranscriptomeConceptsTubular epithelial cellsParietal epithelial cellsEpithelial cellsRenal injuryLTβR signalingTherapeutic targetGlomerular immune complex depositionLymphotoxin β receptor (LTβR) signalingImproved renal functionSerum autoantibody titersHuman tubular epithelial cellsImmune complex depositionMurine lupus modelsProgressive kidney diseaseSuitable therapeutic targetPreclinical mouse modelsDifferent renal compartmentsPotential therapeutic targetΒ Receptor SignalingLymphotoxin β receptorAutoantibody titersRenal inflammationLupus modelsRenal functionRenal biopsy
2001
Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis
Juedes A, Ruddle N. Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2001, 166: 5168-5175. PMID: 11290800, DOI: 10.4049/jimmunol.166.8.5168.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAntigen-Presenting CellsB7-1 AntigenBrainCell LineCell MovementDown-RegulationEncephalomyelitis, Autoimmune, ExperimentalFemaleGrowth InhibitorsHistocompatibility Antigens Class IHistocompatibility Antigens Class IILymphocyte ActivationMacromolecular SubstancesMacrophagesMiceMice, Inbred C57BLMice, KnockoutMicrogliaMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNitric OxideSpinal CordT-LymphocytesConceptsExperimental autoimmune encephalomyelitisT cell proliferationT cellsT cell linesCNS APCCNS APCsAutoimmune encephalomyelitisMHC-IITarget organsInducible NO synthase-deficient miceT cell cytokine productionTh1 T cellsAutoreactive T cellsCell cytokine productionIFN-gamma productionB7-1 expressionSynthase-deficient miceCell proliferationMac-1 cellsCell linesInitiation of diseaseProduction of NOResident microgliaMyelin oligodendrocyteCytokine production
1993
The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-κB in human T-cell lines
Paul N, Millet I, Ruddle N. The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-κB in human T-cell lines. Cytokine 1993, 5: 372-378. PMID: 7505113, DOI: 10.1016/1043-4666(93)90070-l.Peer-Reviewed Original Research1-Methyl-3-isobutylxanthineBase SequenceBinding SitesCell LineCell NucleusChloramphenicol O-AcetyltransferaseColforsinCyclic AMPCytotoxicity, ImmunologicGene Products, taxHuman T-lymphotropic virus 1HumansLymphotoxin-alphaMolecular Sequence DataNF-kappa BOligodeoxyribonucleotidesPromoter Regions, GeneticRepetitive Sequences, Nucleic AcidT-LymphocytesTransfectionTumor Cells, CulturedT Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes
Voskuhl R, Martin R, Bergman C, Dalal M, Ruddle N, Mcfarland H. T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes. Autoimmunity 1993, 15: 137-143. PMID: 7692995, DOI: 10.3109/08916939309043888.Peer-Reviewed Original ResearchConceptsExperimental allergic encephalomyelitisMyelin basic proteinMultiple sclerosisT cell linesT cellsMyelin basic protein-specific T lymphocytesMBP-specific T cell linesMurine experimental allergic encephalomyelitisMBP-specific T cellsAntigen-specific cytotoxic activityFunctional phenotypeEncephalitogenic T cellsHuman T cell lineCell linesTh1 subtypeCandidate autoantigenAllergic encephalomyelitisAutoimmune diseasesInflammatory cellsTumor necrosisT lymphocytesInterleukin-4Animal modelsImmunodominant regionCurrent report
1987
Cytotoxic Factors Secreted by Cells Infected by Human Immunodeficiency Virus Type I
RATNER L, POLMAR S, PAUL N, RUDDLE N. Cytotoxic Factors Secreted by Cells Infected by Human Immunodeficiency Virus Type I. AIDS Research And Human Retroviruses 1987, 3: 147-155. PMID: 3497655, DOI: 10.1089/aid.1987.3.147.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type IVirus type IMononuclear cellsHIV-1Cytotoxic factorPeripheral blood mononuclear cellsHIV-1 infectionBlood mononuclear cellsHIV-1 replicationTumor necrosis factorCell-derived factorCell linesMonocytoid cell linesType ICytotoxic activityAspects of infectionSystemic manifestationsNecrosis factorUninfected counterpartsVirus replicationConditioned mediaCell killingFibroblast cell lineInfectionMurine fibroblast cell line
1985
A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing
Schmid D, Powell M, Mahoney K, Ruddle N. A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing. Cellular Immunology 1985, 93: 68-82. PMID: 3873290, DOI: 10.1016/0008-8749(85)90389-2.Peer-Reviewed Original ResearchConceptsLyt-2Soluble mediatorsT cell-mediated lysisCytotoxic T lymphocyte lineSpecific T cell linesTarget cellsCytotoxic T lymphocytesDose-dependent fashionSupernatant fluidT cell linesSyngeneic splenocytesAppropriate target cellsT lymphocytesCytoplasm of fibroblastsLymphotoxinMild hypotonic shockLytic processLethal hitPreliminary evidenceMediatorsHypotonic shockLethal effectsCellsFibroblastsOsmotic procedure
1982
A critical analysis of the T cell hybrid technique
Beezley B, Ruddle N. A critical analysis of the T cell hybrid technique. Journal Of Immunological Methods 1982, 52: 269-281. PMID: 6752275, DOI: 10.1016/0022-1759(82)90001-1.Peer-Reviewed Original Research
1980
Antigen-specific T-cell hybrids I. Ovalbumin binding T-cell hybrid
Whitaker R, Ruddle N. Antigen-specific T-cell hybrids I. Ovalbumin binding T-cell hybrid. Cellular Immunology 1980, 55: 56-65. PMID: 6159106, DOI: 10.1016/0008-8749(80)90136-7.Peer-Reviewed Original ResearchRegulation of self-recognition by T-cell hybrids
Ruddle N, Beezley B, Eardley D. Regulation of self-recognition by T-cell hybrids. Cellular Immunology 1980, 55: 42-55. PMID: 6968629, DOI: 10.1016/0008-8749(80)90135-5.Peer-Reviewed Original ResearchAntigen specific T cell hybrids—II T cell hybrids which bind azobenzenearsonate
Ruddle N, Beezley B, Lewis G, Goodman J. Antigen specific T cell hybrids—II T cell hybrids which bind azobenzenearsonate. Molecular Immunology 1980, 17: 925-931. PMID: 6163974, DOI: 10.1016/0161-5890(80)90041-3.Peer-Reviewed Original Research