2023
Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer
Ruddle N. Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer. Current Opinion In Physiology 2023, 36: 100705. PMID: 38523879, PMCID: PMC10956444, DOI: 10.1016/j.cophys.2023.100705.Peer-Reviewed Original ResearchHigh endothelial venulesTertiary lymphoid structuresLymphoid organsEndothelial venulesImmune checkpoint blockadeFavorable clinical outcomeAdhesion molecule-1Peripheral node addressinAutoimmune lesionsCheckpoint blockadeClinical outcomesEffector cellsChronic inflammationLymphoid structuresAcute inflammationLymphoid cellsMolecule-1InflammationCentral memoryAdhesion moleculesBlood vesselsPrecursor cellsImmunotherapyVenulesOrgans
2019
Innate Immunity: Recognition and Effector Functions
Kavathas P, Krause P, Ruddle N. Innate Immunity: Recognition and Effector Functions. 2019, 39-53. DOI: 10.1007/978-3-030-25553-4_3.ChaptersDanger-associated molecular patternsPathogen-associated molecular patternsTypes of pathogensMolecular patternsInducer of inflammationSecretion of cytokinesTypes of receptorsChronic inflammationInflammatory responseEffector mechanismsEffector functionsInnate immunityInflammationComplement systemComplement proteinsMicrobial invasionReceptorsFighting infectionsInfectionCell-cell communicationSecretionCell stressNucleic acidsPathogensCells
2013
Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles
Mionnet C, Mondor I, Jorquera A, Loosveld M, Maurizio J, Arcangeli ML, Ruddle NH, Nowak J, Aurrand-Lions M, Luche H, Bajénoff M. Identification of a New Stromal Cell Type Involved in the Regulation of Inflamed B Cell Follicles. PLOS Biology 2013, 11: e1001672. PMID: 24130458, PMCID: PMC3794863, DOI: 10.1371/journal.pbio.1001672.Peer-Reviewed Original ResearchConceptsStromal cell typesB cell folliclesT cell zonesCell typesFate-mapping systemStromal cellsCellular demandB cellsLymph Node Stromal CellsSurvival signalsStromal cell subsetsB cell ablationLN stromal cellsCell zoneAdhesive substrataCell ablationCell subsetsImmune responseCellsFolliclesInflammationSubstrataRegulationTransient boundaryLymphocytes
2000
Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme
Ruddle N. Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme. Progress In Inflammation Research 2000, 83-88. DOI: 10.1007/978-3-0348-8468-6_8.Peer-Reviewed Original ResearchAutoimmune diseasesLymphoid organsLymphoid organ developmentT cellsTarget organsAntigen-specific T cellsAdditional T cellsLocal lymphoid organsTertiary lymphoid organsConsequence of inflammationLymphoid neogenesisClinical relapseAutoimmune inflammationLocal target organLymphoid tissueInflammatory reactionB cellsInflammationTransgenic miceTissue damageDiseaseTNF familyOrgansUnrelated moleculesOrgan development
1999
Lymphoid neoorganogenesis
Ruddle N. Lymphoid neoorganogenesis. Immunologic Research 1999, 19: 119-125. PMID: 10493167, DOI: 10.1007/bf02786481.Peer-Reviewed Original ResearchConceptsVascular cell adhesion moleculeE-selectin adhesion moleculesIntercellular adhesion moleculePeripheral node addressinAdhesion moleculesKnockout miceTertiary lymphoid organsCellular adhesion moleculesNecrosis factor familyLymphoid organ developmentEndothelial cell lineAutoimmune diseasesChronic inflammationLymphoid organsLymphoid tissueCell adhesion moleculeLymphotoxinInflammationMultiple receptorsMicrobial infectionsCell linesMiceOrgan developmentFactor familyAddressin
1997
Mediators of inflammation
Sacca R, Cuff C, Ruddle N. Mediators of inflammation. Current Opinion In Immunology 1997, 9: 851-857. PMID: 9492989, DOI: 10.1016/s0952-7915(97)80189-6.Peer-Reviewed Original Research
1996
Lymphoid Organogenesis and Inflammation Are Mediated by Lymphotoxin
Kratz A, Barten D, Campos-Neto A, Ruddle N. Lymphoid Organogenesis and Inflammation Are Mediated by Lymphotoxin. Serono Symposia USA 1996, 149-153. DOI: 10.1007/978-1-4612-2376-4_15.Peer-Reviewed Original Research
1994
10 Studies of Tolerance, Inflammation, and Autoimmunity in Transgenic Mice
Antonia S, Elliott E, Guerder S, Picarella D, Ruddle N, Flavell R. 10 Studies of Tolerance, Inflammation, and Autoimmunity in Transgenic Mice. 1994, 155-174. DOI: 10.1016/b978-0-12-105760-2.50014-5.Peer-Reviewed Original ResearchAutoreactive T cellsT cellsTransgenic miceT antigen transgenic miceLocal antigen presentationSpecific T cellsInfluence of cytokinesAutoreactive cellsAntigen presentationTissue destructionEffective antigenAutoimmunityClonal expansionMiceTissue remodelingStudy of toleranceAntigenIsletsCellsTissueActivationInflammationHyperplasiaCytokinesExpression