2024
Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses
Cervantes Rincón T, Kapoor T, Keeffe J, Simonelli L, Hoffmann H, Agudelo M, Jurado A, Peace A, Lee Y, Gazumyan A, Guidetti F, Cantergiani J, Cena B, Bianchini F, Tamagnini E, Moro S, Svoboda P, Costa F, Reis M, Ko A, Fallon B, Avila-Rios S, Reyes-Téran G, Rice C, Nussenzweig M, Bjorkman P, Ruzek D, Varani L, MacDonald M, Robbiani D. Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. Cell Reports 2024, 43: 114298. PMID: 38819991, DOI: 10.1016/j.celrep.2024.114298.Peer-Reviewed Original ResearchPowassan virusEnvelope domain IIIYellow fever virusZika virusFever virusSerological neutralizing activityTemperate regionsDengue virusTicksTropical areasInfect humansLineage IMosquito-borne flavivirusNeutralizing activityHuman antibodiesVirusNeurological illnessBrazilFlavivirusesP002P003Human diseasesFactors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil
de Oliveira D, Khalil H, Palma F, Santana R, Nery N, Quintero-Vélez J, Zeppelini C, do Sacramento G, Cruz J, Lustosa R, Ferreira I, Carvalho-Pereira T, Diggle P, Wunder E, Ko A, Lopez Y, Begon M, Reis M, Costa F. Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil. PLOS Neglected Tropical Diseases 2024, 18: e0011292. PMID: 38758957, PMCID: PMC11139309, DOI: 10.1371/journal.pntd.0011292.Peer-Reviewed Original ResearchYears of ageResidents of low-income areasMultinomial logistic regression modelWork-related exposureEpidemiological patternsLow-income areasLogistic regression modelsInformal urban communitiesFactors associated with seropositivityCity of SalvadorPathogenic species of bacteriaUrban settingsUrban communitiesIgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease
Serrano I, Ribeiro G, Santos R, Cruz J, Lanza F, dos Santos E, de Almeida M, de Souza Soares J, Luquetti A, Celedon P, Zanchin N, Santos F, dos Reis M. IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease. American Journal Of Tropical Medicine And Hygiene 2024, 110: 669-676. PMID: 38412539, PMCID: PMC10993828, DOI: 10.4269/ajtmh.23-0652.Peer-Reviewed Original ResearchClinical presentationChronic CDClinical formsSpectrum of clinical presentationsIg profilesSevere cardiac involvementChagas diseaseChronic Chagas diseaseSerum samplesDevelopment of tissue damageHost immune responseCross-sectional studyCardiac involvementIgG3 levelsImmunopathogenic mechanismsDisease progressionProgression of CDRecombinant chimeric proteinImmune responseIgG isotypeIgG3 isotypesTotal IgGMC groupSC groupDisease pathogenesisOverestimation of Severe Acute Respiratory Syndrome Coronavirus 2 Household Transmission in Settings of High Community Transmission: Insights From an Informal Settlement Community in Salvador, Brazil
Ticona J, Nery N, Hitchings M, Belitardo E, Fofana M, Dorión M, Victoriano R, Cruz J, Santana J, de Moraes L, Cardoso C, Ribeiro G, Reis M, Khouri R, Costa F, Ko A, Cummings D. Overestimation of Severe Acute Respiratory Syndrome Coronavirus 2 Household Transmission in Settings of High Community Transmission: Insights From an Informal Settlement Community in Salvador, Brazil. Open Forum Infectious Diseases 2024, 11: ofae065. PMID: 38516384, PMCID: PMC10957159, DOI: 10.1093/ofid/ofae065.Peer-Reviewed Original ResearchSARS-CoV-2Household transmissionRT-PCR positive casesSecondary attack rateAttack rateSARS-CoV-2 infectionSARS-CoV-2 Omicron variantRisk of infectionCommunity acquisitionTherapeutic optionsCOVID-19-related symptomsCase-finding studyHousehold contactsAcquisition of SARS-CoV-2Increased riskSymptom onsetSecondary infectionBooster vaccinationSevere outcomesBiweekly visitsHighest attack rateRT-PCRInfectionCOVID-19 severe outcomesOmicron BADetection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis?
Jacob-Nascimento L, Portilho M, Anjos R, Moreira P, Stauber C, Weaver S, Kitron U, Reis M, Ribeiro G. Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis? Viruses 2024, 16: 235. PMID: 38400011, PMCID: PMC10891727, DOI: 10.3390/v16020235.Peer-Reviewed Original ResearchConceptsChikungunya virus infectionAcute-phase seraOral fluidChikungunya virusIgM seroconversionChikungunya virus diagnosisUrine samplesAcute febrile illnessConvalescent-phase seraAcute chikungunyaChikungunya patientsChikungunya virus RNADisease courseFebrile illnessPaired seraRT-qPCRAcute phaseIgM detectionConvalescent-phasePatientsControl group samplesSerumUrineCHIKV transmissionIgMLong-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil
Reis J, Azevedo J, de Oliveira A, de Oliveira Menezes A, Pedrosa M, dos Santos M, Ribeiro L, de Freitas H, Gouveia E, Teles M, da Glória Carvalho M, Reis M, Nascimento-Carvalho C, Verani J. Long-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil. Vaccine 2024, 42: 591-597. PMID: 38184393, PMCID: PMC10872423, DOI: 10.1016/j.vaccine.2023.12.055.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosInvasive pneumococcal diseaseLower-middle-income settingsPCV10 introductionInvasive pneumococcal disease incidenceProspective laboratory-based surveillanceNational infant immunization programsPre-PCV10 periodNon-vaccine serotypesRate ratiosInfant immunization programIncidence ratePneumococcal conjugate vaccineLaboratory-based surveillanceIPD incidenceImpact of PCV10Multiplex polymerase chain reactionMetropolitan region of SalvadorCompare ratesPCV10 serotypesLong-term impactSterile sitesQuellung reactionSerotype 15BVaccine-typeSometimes, the size matters: Wing geometric morphometrics as a tool to assess domiciliation by Triatoma sordida (Stäl 1859)
Ribeiro-Jr G, Reis J, Vaccarezza F, Silva A, Lanza F, Miranda D, Gurgel-Gonçalves R, Reis M. Sometimes, the size matters: Wing geometric morphometrics as a tool to assess domiciliation by Triatoma sordida (Stäl 1859). Revista Da Sociedade Brasileira De Medicina Tropical 2024, 57: e00709-2024. PMID: 39140583, PMCID: PMC11315410, DOI: 10.1590/0037-8682-0516-2023.Peer-Reviewed Original ResearchConceptsWing geometric morphometricsGeometric morphometric analysisPeridomestic populationsTriatoma sordidaWing geometric morphometryGeometric morphometryGeometric morphometricsHousing populationSouth AmericaT. sordidaMorphometric analysisHemelytraPublic health concernDomiciliationMorphometricsPopulation
2023
Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community
Anjos R, Portilho M, Jacob-Nascimento L, Carvalho C, Moreira P, Sacramento G, Nery N, de Oliveira D, Cruz J, Cardoso C, Argibay H, Plante K, Plante J, Weaver S, Kitron U, Reis M, Ko A, Costa F, Ribeiro G. Dynamics of chikungunya virus transmission in the first year after its introduction in Brazil: A cohort study in an urban community. PLOS Neglected Tropical Diseases 2023, 17: e0011863. PMID: 38150470, PMCID: PMC10775974, DOI: 10.1371/journal.pntd.0011863.Peer-Reviewed Original ResearchExtensive transmission of SARS-CoV-2 BQ.1* variant in a population with high levels of hybrid immunity: A prevalence survey
Ticona J, Xiao M, Li D, Nery N, Hitchings M, Belitardo E, Fofana M, Victoriano R, Cruz J, de Moraes L, Strobel I, Silva J, do Aragão Filho A, Ribeiro G, Reis M, Costa F, Khouri R, Ko A, Cummings D. Extensive transmission of SARS-CoV-2 BQ.1* variant in a population with high levels of hybrid immunity: A prevalence survey. International Journal Of Infectious Diseases 2023, 139: 159-167. PMID: 38070701, PMCID: PMC10784150, DOI: 10.1016/j.ijid.2023.11.039.Peer-Reviewed Original ResearchThe impact of COVID-19 on microbiological profile and antibiotic consumption in ICU: a retrospective study in an infectious disease hospital in Brazil
de França Diniz Rocha V, da Silva E, Azevedo J, Ribeiro M, Reis M, Barros T, Reis J. The impact of COVID-19 on microbiological profile and antibiotic consumption in ICU: a retrospective study in an infectious disease hospital in Brazil. The Brazilian Journal Of Infectious Diseases 2023, 28: 103705. PMID: 38065221, PMCID: PMC10764251, DOI: 10.1016/j.bjid.2023.103705.Peer-Reviewed Original ResearchConceptsIntensive care unitInfectious Diseases HospitalAntimicrobial resistanceMicrobiological profileCandida sppRetrospective studyTracheal secretionsCarbapenem-resistant A. baumanniiConsequences of antimicrobial resistanceIntensive care unit patient-daysImpact of antimicrobial resistanceMultidrug-resistant Enterococcus faeciumCharacteristics of patientsConsumption of ceftriaxoneConsumption of antibioticsPiperacillin-tazobactamUnique characteristics of patientsA. baumanniiAcinetobacter baumanniiAntibiotic consumptionEnterobacter speciesIncidence densityESKAPE groupClinical culturesKlebsiella pneumoniaePredictors of Neurodevelopment in Microcephaly Associated with Congenital Zika Syndrome: A Prospective Study
Mattos A, Rastely-Junior V, Pires M, Aguilar J, Lessa M, Regis C, Wanderley M, Leony J, Bouzon J, Ballalai V, Vieira C, Carvalho G, Almeida J, Nery N, Leal R, Costa F, Ko A, Reis M, Oliveira-Filho J. Predictors of Neurodevelopment in Microcephaly Associated with Congenital Zika Syndrome: A Prospective Study. Children 2023, 10: 1831. PMID: 38136033, PMCID: PMC10741834, DOI: 10.3390/children10121831.Peer-Reviewed Original ResearchCongenital Zika syndromeEvans indexZika syndromeHead circumferenceNeurodevelopmental delayMedian head circumferenceBayley-III scoresCT scan analysisMicrocephaly AssociatedNeurodevelopmental examinationProspective studyVentricle enlargementBrain abnormalitiesCongenital manifestationsMultiprofessional teamGross motorNeonate periodDevelopmental anomaliesDevelopmental delaySyndromeMicrocephalyBlinded expertsMonthsChildrenCircumferenceCARACTERIZAÇÃO CLÍNICO-EPIDEMIOLÓGICA DE CASOS DE INFECÇÕES DE CORRENTE SANGUÍNEA CAUSADAS POR ENTEROBACTERALES EM DOIS HOSPITAIS TERCIÁRIOS DE SALVADOR, BAHIA
de Araújo L, Bomfim A, Barbosa M, Azevedo J, da Silva Cavalcanti G, Boaventura E, de Oliveira Silva M, de Andrade Barberino M, Reis M, Reis J. CARACTERIZAÇÃO CLÍNICO-EPIDEMIOLÓGICA DE CASOS DE INFECÇÕES DE CORRENTE SANGUÍNEA CAUSADAS POR ENTEROBACTERALES EM DOIS HOSPITAIS TERCIÁRIOS DE SALVADOR, BAHIA. The Brazilian Journal Of Infectious Diseases 2023, 27: 103338. DOI: 10.1016/j.bjid.2023.103338.Peer-Reviewed Original ResearchSpatial distribution of congenital syphilis in the state of Bahia, Brazil from 2009 to 2018
Vital C, Reis R, de Souza Soares J, Miranda D, Reis M. Spatial distribution of congenital syphilis in the state of Bahia, Brazil from 2009 to 2018. Frontiers In Epidemiology 2023, 3: 1234580. PMID: 38516337, PMCID: PMC10956362, DOI: 10.3389/fepid.2023.1234580.Peer-Reviewed Original ResearchPrenatal careLive Birth Information SystemCongenital syphilisInadequate prenatal careLow educational levelNotifiable Diseases Information SystemMunicipalities of BahiaPublic health problemWomen of childbearing ageCS incidenceEducation levelWHO targetHealth problemsYoung mothersCarePregnant womenLive birthsAnalysis of dataCS casesChildbearing ageTemporal trendsCases of CSInformation systemsSyphilisEcological studiesAnalyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas
de Moraes L, Portilho M, Vrancken B, Van den Broeck F, Santos L, Cucco M, Tauro L, Kikuti M, Silva M, Campos G, Reis M, Barral A, Barral-Netto M, Boaventura V, Vandamme A, Theys K, Lemey P, Ribeiro G, Khouri R. Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas. Viruses 2023, 15: 1236. PMID: 37376536, PMCID: PMC10301521, DOI: 10.3390/v15061236.Peer-Reviewed Original ResearchConceptsAcute ZIKV infectionSpread of ZIKVPublic health responseZika virus outbreakClinical symptomsZIKV infectionHealth responseZIKVZIKV genomeViral spreadGenomic surveillanceVirus outbreakInfectionSubsequent disseminationSurveillance effortsZIKV dynamicsFuture surveillance effortsOutbreakEarly stagesZika virus RNA persistence and recovery in water and wastewater: An approach for Zika virus surveillance in resource-constrained settings
Zhu K, Hill C, Muirhead A, Basu M, Brown J, Brinton M, Hayat M, Venegas-Vargas C, Reis M, Casanovas-Massana A, Meschke J, Ko A, Costa F, Stauber C. Zika virus RNA persistence and recovery in water and wastewater: An approach for Zika virus surveillance in resource-constrained settings. Water Research 2023, 241: 120116. PMID: 37270953, PMCID: PMC10330535, DOI: 10.1016/j.watres.2023.120116.Peer-Reviewed Original ResearchConceptsZIKV RNAZIKV outbreakZika virus surveillanceNucleic acid testingZika virus epidemicResource-constrained settingsWidespread diagnostic testingPublic health surveillanceReverse transcription droplet digital PCRTranscription droplet digital PCRAcid testingRNA persistenceDiagnostic testingHealth surveillanceDroplet digital PCRVirus epidemicVirus surveillanceIndividual testingSuch casesDigital PCRSurveillanceOutbreakRNAZIKVRecoveryEpidemiological indicators of Chagas disease in the metropolitan region of Salvador, Bahia, Brazil
Lanza F, Ribeiro-Jr G, Miranda D, Santos F, Carvalho C, Cunha G, Carneiro I, Reis R, Cunha J, Cardoso C, Soares J, Araújo F, Reis M. Epidemiological indicators of Chagas disease in the metropolitan region of Salvador, Bahia, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0185-2022. PMID: 36820652, PMCID: PMC9957123, DOI: 10.1590/0037-8682-0185-2022.Peer-Reviewed Original ResearchToll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study
Barbosa L, Santiago M, Moretto V, Athanazio D, Takahashi D, Reis E, Lopes M, Lemaire D, Reis M. Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study. Brazilian Journal Of Biology 2023, 83: e244123. PMID: 34161457, DOI: 10.1590/1519-6984.244123.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusToll-like receptor 9TLR9 polymorphismsSLE patientsLupus erythematosusSingle nucleotide polymorphismsToll-like receptor 9 polymorphismsControl groupTLR9 single nucleotide polymorphismsSLE patient groupInnate immune systemDiscoid rashSLE populationClinical manifestationsPatient groupAutoimmune diseasesReceptor 9Brazilian patientsTLR9 geneImmune systemPatientsPilot studyAllele GAllele CGenotype frequenciesPrevalence of Genotypic Resistance Mutations in Patients with Chronic Hepatitis B (HBV) Treated with Entecavir and Tenofovir in Two Reference Centers in the North and Northeast of Brazil
Pacheco S, Schinoni M, Stocker A, Paraná R, Reis M, Silva L. Prevalence of Genotypic Resistance Mutations in Patients with Chronic Hepatitis B (HBV) Treated with Entecavir and Tenofovir in Two Reference Centers in the North and Northeast of Brazil. Medical Research Archives 2023, 11 DOI: 10.18103/mra.v11i3.3473.Peer-Reviewed Original ResearchGenotypic resistance mutationsResistance mutationsHepatitis BChronic hepatitis BFirst-line treatmentVaccine escape mutationsHepatitis B virusChronic HBVAntiviral treatmentLine treatmentLiver diseaseTherapeutic managementB virusEscape mutationsGenotypic resistanceReference centerPatientsGenetic mutationsEntecavirHBVTenofovirTreatmentNortheast of BrazilPresent studyNucleotide analoguesMalaria and COVID-19 coinfection in a non-malaria-endemic area in Brazil
Rocha V, Brasil L, Gomes E, Khouri R, Ferreira G, Vasconcelos B, Gouveia M, Santos T, Reis M, Lacerda M. Malaria and COVID-19 coinfection in a non-malaria-endemic area in Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0598-2022. PMID: 37222351, PMCID: PMC10204151, DOI: 10.1590/0037-8682-0598-2022.Peer-Reviewed Original ResearchConceptsCOVID-19 coinfectionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Severe vivax malariaIntensive care unitSyndrome coronavirus 2Coronavirus disease 2019Transcription-quantitative PCR resultsSevere malariaCare unitCoronavirus 2Vivax malariaDifferential diagnosisDisease 2019Febrile diseaseEndemic areasPlasmodium vivaxEndemic regionsCoinfectionRapid testMalariaPCR resultsQuantitative PCRHypotensionBartonella in Norway rats (Rattus norvegicus) from the urban slum environment in Brazil
Zeppelini C, Oliveira D, Kosoy M, Reis M, Ko A, Childs J, Costa F. Bartonella in Norway rats (Rattus norvegicus) from the urban slum environment in Brazil. Anais Da Academia Brasileira De Ciências 2023, 95: e20220809. PMID: 37909607, DOI: 10.1590/0001-3765202320220809.Peer-Reviewed Original Research