2021
Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors
Rodart I, Pares M, Mendes A, Accardo C, Martins J, Silva C, Carvalho F, Barreto J, Reis M, Tersariol I, Nader H. Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors. Molecules 2021, 26: 3892. PMID: 34202190, PMCID: PMC8270308, DOI: 10.3390/molecules26133892.Peer-Reviewed Original ResearchConceptsHepatitis C virusAsymptomatic blood donorsLiver fibrosisBlood donorsSerum hyaluronanHCV infectionSerum levelsGGT serum levelsHA serum levelsHCV RNA detectionHCV viral loadProgressive liver diseaseAdvanced liver fibrosisHigher ALT levelsSignificant liver fibrosisNormal ALTHCV viremiaALT levelsAntiviral treatmentAsymptomatic personsBiopsy confirmationHCV samplesLiver biomarkersLiver diseaseViral load
2011
Biomarkers of Hemolysis and Inflammation in Sickle Cell Disease Children: Association with Nasopharynx and Oropharynx Bacteria colonization
Rocha L, Seixas M, Cerqueira B, Lopes V, Reis M, Goncalves M. Biomarkers of Hemolysis and Inflammation in Sickle Cell Disease Children: Association with Nasopharynx and Oropharynx Bacteria colonization. Blood 2011, 118: 2140. DOI: 10.1182/blood.v118.21.2140.2140.Peer-Reviewed Original ResearchHigh ferritin serum levelsFerritin serum levelsSCD patientsSerum levelsS. pneumoniaeNasopharyngeal colonizationNasopharynx colonizationHbSS genotypeSickle cell disease childrenS. aureusBacteria colonizationBiomarkers of hemolysisHigher leukocyte numbersPneumococcal penicillin resistanceHigher neutrophil countS. pneumoniae colonizationCause of infectionCross-sectional studyOccurrence of infectionMultivariate analysis modelNeutrophil countSCD childrenHigh ferritinPneumonia occurrencePneumoniae colonizationTNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia
Cajado C, Cerqueira B, Couto F, Moura-Neto J, Vilas-Boas W, Dorea M, Lyra I, Barbosa C, Reis M, Goncalves M. TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia. Cytokine 2011, 56: 312-317. PMID: 21802960, DOI: 10.1016/j.cyto.2011.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesAnemia, Sickle CellBiomarkersCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayHaplotypesHumansInterleukin-8Medical History TakingPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthTumor Necrosis Factor-alphaConceptsSickle cell anemiaTNF-alpha -308GT gene polymorphismGene polymorphismsIL-8Serum levelsMedical historyTNF-alphaCell anemiaHigher TNF-alpha levelsIL-8 gene polymorphismsA alleleClassical biomarkersSteady-state sickle cell anemiaTNF-alpha levelsHeterogeneous clinical outcomesLogistic regression analysisYears of ageCytokine levelsClinical outcomesImmunological biomarkersHealthy controlsPatient outcomesInterleukin-8SCA patients
2009
Adhesion Molecules Interaction with Markers of Lipid Metabolism, Hemolysis, Endothelial Dysfunction and Medical Histories Among Steady-State Sickle Cell Anemia Patients.
Cerqueira B, Boas W, Clarêncio J, Andrade D, Zanette A, Reis M, Neto J, Cesar R, Goncalves M. Adhesion Molecules Interaction with Markers of Lipid Metabolism, Hemolysis, Endothelial Dysfunction and Medical Histories Among Steady-State Sickle Cell Anemia Patients. Blood 2009, 114: 2553. DOI: 10.1182/blood.v114.22.2553.2553.Peer-Reviewed Original ResearchSickle cell anemia patientsSickle cell anemiaSoluble adhesion moleculesHigher serum levelsMedical historyAnemia patientsAdhesion moleculesEndothelial dysfunctionSerum levelsICAM-1Aspartate transferaseSteady-state sickle cell anemia patientsDensity lipoproteinControl groupVCAM-1 adhesion moleculesLipid metabolismChronic clinical complicationsVaso-occlusive painSurface adhesion molecule expressionNeutrophil adhesion moleculesSoluble ICAM-1Complete medical historyAdhesion molecule expressionHigh-density lipoproteinLow-density lipoprotein
2006
Folate, vitamin B12 and total homocysteine levels in neonates from Brazil
Couto F, Moreira L, dos Santos D, Reis M, Gonçalves M. Folate, vitamin B12 and total homocysteine levels in neonates from Brazil. European Journal Of Clinical Nutrition 2006, 61: 382-386. PMID: 16988650, DOI: 10.1038/sj.ejcn.1602528.Peer-Reviewed Original ResearchConceptsTotal homocysteine levelsGroup 1Higher socioeconomic statusVitamin B12Homocysteine levelsGroup 2Maternal environmental risk factorsNewborn health statusSocioeconomic statusVitamin B12 levelsCross-sectional transversal studyMothers of babiesCord blood samplesHigh-risk factorsTime of deliveryEnvironmental risk factorsFolate binding proteinAdequate health careFluorescence polarization immunoassayPregnancy complicationsB12 levelsSerum levelsVitamin supplementationNewborn healthPrenatal care