2024
IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease
Serrano I, Ribeiro G, Santos R, Cruz J, Lanza F, dos Santos E, de Almeida M, de Souza Soares J, Luquetti A, Celedon P, Zanchin N, Santos F, dos Reis M. IgG Isotypes Targeting a Recombinant Chimeric Protein of Trypanosoma cruzi in Different Clinical Presentations of Chronic Chagas Disease. American Journal Of Tropical Medicine And Hygiene 2024, 110: 669-676. PMID: 38412539, PMCID: PMC10993828, DOI: 10.4269/ajtmh.23-0652.Peer-Reviewed Original ResearchClinical presentationChronic CDClinical formsSpectrum of clinical presentationsIg profilesSevere cardiac involvementChagas diseaseChronic Chagas diseaseSerum samplesDevelopment of tissue damageHost immune responseCross-sectional studyCardiac involvementIgG3 levelsImmunopathogenic mechanismsDisease progressionProgression of CDRecombinant chimeric proteinImmune responseIgG isotypeIgG3 isotypesTotal IgGMC groupSC groupDisease pathogenesis
2009
Lipoprotein Cholesterol and Triglyceride in Children with Steady-State Sickle Cell Disease.
Seixas M, Rocha L, Carvalho M, Menezes J, Lyra I, Nascimento V, Couto R, Atta A, Reis M, Goncalves M. Lipoprotein Cholesterol and Triglyceride in Children with Steady-State Sickle Cell Disease. Blood 2009, 114: 1547. DOI: 10.1182/blood.v114.22.1547.1547.Peer-Reviewed Original ResearchHigh-density lipoprotein cholesterolLipoprotein cholesterolSickle cell disease pathogenesisPatients' medical recordsSickle cell diseasePro-fibrinolytic activityTotal cholesterolSignificant positive associationProspective studyMedical recordsSteady state childrenCell diseaseClinical dataHealthy subjectsDisease pathogenesisHematological analysisCholesterolCell counterPositive associationNegative associationElectronic cell counterAssociationPatientsPathogenesisMonocytes