2016
Antimicrobial activity of antisense peptide–peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms
Otsuka T, Brauer AL, Kirkham C, Sully EK, Pettigrew MM, Kong Y, Geller BL, Murphy TF. Antimicrobial activity of antisense peptide–peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms. Journal Of Antimicrobial Chemotherapy 2016, 72: 137-144. PMID: 27986898, PMCID: PMC5161047, DOI: 10.1093/jac/dkw384.Peer-Reviewed Original Research
2015
Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease
Chao Y, Marks LR, Pettigrew MM, Hakansson AP. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease. Frontiers In Cellular And Infection Microbiology 2015, 4: 194. PMID: 25629011, PMCID: PMC4292784, DOI: 10.3389/fcimb.2014.00194.Peer-Reviewed Original ResearchConceptsNasopharyngeal environmentConcomitant virus infectionPneumococcal biofilmsMiddle ear infectionRespiratory epithelial cellsMillions of infectionsPneumococcal biofilm formationPneumococcal diseaseEar infectionsSterile sitesInvasive diseasePneumococcal colonizationHigh prevalenceVirus infectionDisease processDistinct phenotypic propertiesMucosal surfacesStreptococcus pneumoniaeVaccine escapeHuman nasopharynxDiseaseEpithelial cellsInfectionPneumococciAntibiotic resistance
2014
Dynamic Changes in the Streptococcus pneumoniae Transcriptome during Transition from Biofilm Formation to Invasive Disease upon Influenza A Virus Infection
Pettigrew MM, Marks LR, Kong Y, Gent JF, Roche-Hakansson H, Hakansson AP. Dynamic Changes in the Streptococcus pneumoniae Transcriptome during Transition from Biofilm Formation to Invasive Disease upon Influenza A Virus Infection. Infection And Immunity 2014, 82: 4607-4619. PMID: 25135685, PMCID: PMC4249342, DOI: 10.1128/iai.02225-14.Peer-Reviewed Original ResearchConceptsWhole transcriptome shotgun sequencingPneumococcal transcriptomeTransparent colony phenotypeVirus infectionTranscriptional differencesShotgun sequencingUpregulated genesFebrile range temperaturesColony phenotypeInfluenza A Virus InfectionNutrient availabilityTranscriptomeS. pneumoniae pathogenesisA virus infectionProduction of bacteriocinsHost immune responsePlanktonic cellsBiofilm formationGenesPlanktonic bacteriaBiofilm bacteriaExtracellular ATPCarbohydrate metabolismBacteriaEnzymatic assay