2024
Trends in COVID‐19–Attributable Hospitalizations Among Adults With Laboratory‐Confirmed SARS‐CoV‐2—COVID‐NET, June 2020 to September 2023
Taylor C, Whitaker M, Patton M, Melgar M, Kirley P, Kawasaki B, Yousey‐Hindes K, Openo K, Ryan P, Kim S, Como‐Sabetti K, Solhtalab D, Barney G, Tesini B, Moran N, Sutton M, Talbot H, Olsen K, Havers F. Trends in COVID‐19–Attributable Hospitalizations Among Adults With Laboratory‐Confirmed SARS‐CoV‐2—COVID‐NET, June 2020 to September 2023. Influenza And Other Respiratory Viruses 2024, 18: e70021. PMID: 39496579, PMCID: PMC11534501, DOI: 10.1111/irv.70021.Peer-Reviewed Original Research
2021
Clinical Trends Among U.S. Adults Hospitalized With COVID-19, March to December 2020
Garg S, Patel K, Pham H, Whitaker M, O'Halloran A, Milucky J, Anglin O, Kirley PD, Reingold A, Kawasaki B, Herlihy R, Yousey-Hindes K, Maslar A, Anderson EJ, Openo KP, Weigel A, Teno K, Ryan PA, Monroe ML, Reeg L, Kim S, Como-Sabetti K, Bye E, Davis S, Eisenberg N, Muse A, Barney G, Bennett NM, Felsen CB, Billing L, Shiltz J, Sutton M, Abdullah N, Talbot HK, Schaffner W, Hill M, Chatelain R, Wortham J, Taylor C, Hall A, Fry AM, Kim L, Havers FP. Clinical Trends Among U.S. Adults Hospitalized With COVID-19, March to December 2020. Annals Of Internal Medicine 2021, 174: m21-1991. PMID: 34370517, PMCID: PMC8381761, DOI: 10.7326/m21-1991.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine MonophosphateAdolescentAdrenal Cortex HormonesAdultAge DistributionAgedAlanineAntiviral AgentsCOVID-19Critical CareCross-Sectional StudiesFemaleHospitalizationHumansIntensive Care UnitsLength of StayMaleMiddle AgedPandemicsRespiration, ArtificialSARS-CoV-2United StatesVasoconstrictor AgentsYoung AdultConceptsICU admissionClinical trendsMechanical ventilationCOVID-19COVID-19-associated hospitalizationIntensive care unit admissionLaboratory-confirmed COVID-19U.S. adultsNon-Hispanic black personsCare unit admissionHospital death rateNoninvasive respiratory supportUse of remdesivirPercentage of interventionsCross-sectional studyCOVID-19 vaccineNon-Hispanic whitesSystemic corticosteroidsUnit admissionVasopressor useHospitalized adultsRespiratory supportCase patientsMedian ageSubstantial morbidityRates of Influenza-Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death by Race and Ethnicity in the United States From 2009 to 2019
O’Halloran A, Holstein R, Cummings C, Kirley P, Alden NB, Yousey-Hindes K, Anderson EJ, Ryan P, Kim S, Lynfield R, McMullen C, Bennett NM, Spina N, Billing LM, Sutton M, Schaffner W, Talbot HK, Price A, Fry AM, Reed C, Garg S. Rates of Influenza-Associated Hospitalization, Intensive Care Unit Admission, and In-Hospital Death by Race and Ethnicity in the United States From 2009 to 2019. JAMA Network Open 2021, 4: e2121880. PMID: 34427679, PMCID: PMC8385599, DOI: 10.1001/jamanetworkopen.2021.21880.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalizationsIntensive care unit admissionCare unit admissionCross-sectional studyHospitalization ratesPacific Islander childrenHospital deathICU admissionUnit admissionInfluenza seasonMAIN OUTCOMELaboratory-confirmed influenza-associated hospitalizationsAge groupsAge-adjusted hospitalization ratesHospital death rateICU admission rateInfluenza-associated diseaseInfluenza-associated outcomesIn-Hospital DeathSevere influenza diseaseHispanic childrenPopulation-based surveillanceWhite personsAlaska NativesAge-stratified rates
2019
Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season
Rolfes MA, Flannery B, Chung JR, O’Halloran A, Garg S, Belongia EA, Gaglani M, Zimmerman RK, Jackson ML, Monto AS, Alden NB, Anderson E, Bennett NM, Billing L, Eckel S, Kirley PD, Lynfield R, Monroe ML, Spencer M, Spina N, Talbot HK, Thomas A, Torres SM, Yousey-Hindes K, Singleton JA, Patel M, Reed C, Fry AM, McLean H, King J, Nowalk M, Balasubramani G, Bear T, Hickey R, Williams J, Reis E, Moehling K, Eng H, Jackson L, Smith M, Raiyani C, Clipper L, Murthy K, Chen W, Reis M, Petrie J, Malosh R, McSpadden E, Segaloff H, Cheng C, Truscon R, Johnson E, Lamerato L, Rosenblum B, Ford S, Johnson M, Raviotta J, Sax T, Steele J, Susick M, Chabra R, Garofolo E, Iozzi P, Kevish B, Middleton D, Urbanski L, Ponder T, Crumbaker T, Iosefo I, Sleeth P, Gandy V, Bounds K, Kylberg M, Rao A, Fader R, Walker K, Volz M, Ray J, Price D, Thomas J, Wehbe-Janek H, Beeram M, Boyd J, Walkowiak J, Probe R, Couchman G, Motakef S, Arroliga A, Kaniclides A, Bouldin E, Baker C, Berke K, Smith M, Rajesh N, Alleman E, Bauer S, Groesbeck M, Brundidge K, Hafeez N, Jackson J, Anastasia I, Kadoo G, Petnic S, Ryan A, Maslar A, Meek J, Chen R, Stephens S, Thomas S, Segler S, Openo K, Fawcett E, Farley M, Martin A, Ryan P, Sunkel R, Lutich T, Perlmutter R, Grace B, Blood T, Zerrlaut C, McMahon M, Strain A, Christensen J, Angeles K, Butler L, Khanlian S, Mansmann R, McMullen C, Pradhan E, Manzi K, Felsen C, Gaitan M, Long K, Fisher N, Hawley E, O’Shaughnessy R, Scott M, Crawford C, Schaffner W, Markus T, Leib K, Dyer K, Santibanez T, Zhai Y, Lu P, Srivastav A, Hung M. Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season. Clinical Infectious Diseases 2019, 69: 1845-1853. PMID: 30715278, PMCID: PMC7188082, DOI: 10.1093/cid/ciz075.Peer-Reviewed Original ResearchConceptsInfluenza-associated illnessVaccine effectivenessInfluenza vaccinationInfluenza seasonMedical visitsCurrent influenza vaccinationInfluenza-associated outcomesInfluenza vaccine coverageInfluenza vaccine effectivenessLaboratory-confirmed influenzaTest-negative designInfluenza virus infectionAge-specific estimatesInfluenza B.Vaccine coverageDisease burdenVirus infectionSubstantial burdenAmbulatory settingVaccinationHospitalizationImproved vaccinesInfluenzaIllnessVisits
2017
Social determinants of influenza hospitalization in the United States
Chandrasekhar R, Sloan C, Mitchel E, Ndi D, Alden N, Thomas A, Bennett NM, Kirley PD, Hill M, Anderson EJ, Lynfield R, Yousey‐Hindes K, Bargsten M, Zansky SM, Lung K, Schroeder M, Monroe M, Eckel S, Markus TM, Cummings CN, Garg S, Schaffner W, Lindegren ML. Social determinants of influenza hospitalization in the United States. Influenza And Other Respiratory Viruses 2017, 11: 479-488. PMID: 28872776, PMCID: PMC5720587, DOI: 10.1111/irv.12483.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioInfluenza hospitalizationsLaboratory-confirmed influenza-associated hospitalizationsHigher adjusted odds ratioPopulation-based surveillance systemInfluenza-associated hospitalizationsInfluenza seasonSubstantial morbidityVs 5Odds ratioHospitalizationHousehold crowdingSocial determinantsTractIndividual factorsMultilevel regression modelsSocioeconomic determinantsAfrican AmericansSurveillance systemRegression modelsUnited StatesHispanicsIndividual-level determinantsDeterminantsMorbidityInfluenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza
Arriola C, Garg S, Anderson EJ, Ryan PA, George A, Zansky SM, Bennett N, Reingold A, Bargsten M, Miller L, Yousey-Hindes K, Tatham L, Bohm SR, Lynfield R, Thomas A, Lindegren ML, Schaffner W, Fry AM, Chaves SS. Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza. Clinical Infectious Diseases 2017, 65: 1289-1297. PMID: 28525597, PMCID: PMC5718038, DOI: 10.1093/cid/cix468.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaInfluenza vaccinationDisease severityInfluenza seasonIntensive care unit admissionCare unit admissionMultivariable logistic regressionProbability of vaccinationCommunity-dwelling adultsHospital LOSICU LOSUnvaccinated patientsHospital deathICU admissionICU lengthUnit admissionAntiviral treatmentIllness onsetAdverse outcomesOutcome measuresVaccine virusAge strataVaccinationLogistic regressionPropensity score
2016
Influenza-Related Hospitalizations and Poverty Levels - United States, 2010-2012.
Hadler JL, Yousey-Hindes K, Pérez A, Anderson EJ, Bargsten M, Bohm SR, Hill M, Hogan B, Laidler M, Lindegren ML, Lung KL, Mermel E, Miller L, Morin C, Parker E, Zansky SM, Chaves SS. Influenza-Related Hospitalizations and Poverty Levels - United States, 2010-2012. MMWR Morbidity And Mortality Weekly Report 2016, 65: 101-5. PMID: 26866729, DOI: 10.15585/mmwr.mm6505a1.Peer-Reviewed Original ResearchConceptsInfluenza related hospitalizationsInfluenza-related diseaseInfluenza-related hospitalizationsAge-adjusted incidenceAnnual influenza vaccineLow-poverty census tractsCensus tractsHigh-poverty census tractsFederal poverty levelInfluenza seasonHospitalization incidenceInfluenza vaccineHospitalization dataSevere diseaseCurrent recommendationsVaccination effortsAntiviral agentsVaccination outreachSocioeconomic status measuresStatus measuresSurveillance sitesSurveillance data analysisTractSES dataIncidence
2015
Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials
Baggs J, Yousey-Hindes K, Ashley ED, Meek J, Dumyati G, Cohen J, Wise ME, McDonald LC, Lessa FC. Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials. Vaccine 2015, 33: 6241-6249. PMID: 26450660, PMCID: PMC4702247, DOI: 10.1016/j.vaccine.2015.09.078.Peer-Reviewed Original ResearchConceptsEmerging Infections ProgramHigh-risk groupRisk groupsRisk scoreIndex hospitalizationHospital dischargeDerivation cohortVaccine trialsValidation cohortDifficile infectionCox proportional hazards modelRisk of CDIAcute care hospitalizationIdentification of patientsClostridium difficile infectionHospital discharge dataNumber of hospitalizationsLow-risk groupProportional hazards modelLarge academic centerAdmission diagnosisPrimary outcomeInpatient stayPatient populationPharmacy data
2014
Comparing Clinical Characteristics Between Hospitalized Adults With Laboratory-Confirmed Influenza A and B Virus Infection
Su S, Chaves SS, Perez A, D'Mello T, Kirley PD, Yousey-Hindes K, Farley MM, Harris M, Sharangpani R, Lynfield R, Morin C, Hancock EB, Zansky S, Hollick GE, Fowler B, McDonald-Hamm C, Thomas A, Horan V, Lindegren ML, Schaffner W, Price A, Bandyopadhyay A, Fry AM. Comparing Clinical Characteristics Between Hospitalized Adults With Laboratory-Confirmed Influenza A and B Virus Infection. Clinical Infectious Diseases 2014, 59: 252-255. PMID: 24748521, DOI: 10.1093/cid/ciu269.Peer-Reviewed Original ResearchInfluenza‐related hospitalization of adults associated with low census tract socioeconomic status and female sex in New Haven County, Connecticut, 2007‐2011
Tam K, Yousey‐Hindes K, Hadler JL. Influenza‐related hospitalization of adults associated with low census tract socioeconomic status and female sex in New Haven County, Connecticut, 2007‐2011. Influenza And Other Respiratory Viruses 2014, 8: 274-281. PMID: 24382111, PMCID: PMC4181475, DOI: 10.1111/irv.12231.Peer-Reviewed Original ResearchConceptsAge-adjusted incidenceInfluenza seasonNeighborhood socioeconomic statusSocioeconomic statusFemale sexVaccination effortsCensus tract socioeconomic statusFuture influenza vaccination effortsActive population-based surveillanceLower neighborhood socioeconomic statusSES measuresHospitalizations of adultsInfluenza-related hospitalizationsPopulation-based surveillanceInfluenza hospitalizationsInfluenza infectionCostly complicationRelative riskFemale incidenceHigh riskHigh incidenceHospitalizationNew Haven CountyResidential addressesAge groups
2013
Heavy alcohol use as a risk factor for severe outcomes among adults hospitalized with laboratory-confirmed influenza, 2005–2012
Greenbaum A, Chaves S, Perez A, Aragon D, Bandyopadhyay A, Bennett N, Fowler B, Hancock E, Lynfield R, McDonald-Hamm C, Reingold A, Ryan P, Schaffner W, Sharangpani R, Spencer M, Thomas A, Yousey-Hindes K, Zansky S, Finelli L. Heavy alcohol use as a risk factor for severe outcomes among adults hospitalized with laboratory-confirmed influenza, 2005–2012. Infection 2013, 42: 165-170. PMID: 24243481, DOI: 10.1007/s15010-013-0534-8.Peer-Reviewed Original ResearchHospital-onset influenza hospitalizations—United States, 2010-2011
Jhung MA, D'Mello T, Pérez A, Aragon D, Bennett NM, Cooper T, Farley MM, Fowler B, Grube SM, Hancock EB, Lynfield R, Morin C, Reingold A, Ryan P, Schaffner W, Sharangpani R, Tengelsen L, Thomas A, Thurston D, Yousey-Hindes K, Zansky S, Finelli L, Chaves SS. Hospital-onset influenza hospitalizations—United States, 2010-2011. American Journal Of Infection Control 2013, 42: 7-11. PMID: 24183534, DOI: 10.1016/j.ajic.2013.06.018.Peer-Reviewed Original ResearchConceptsIntensive care unitChronic medical conditionsCare unitHO casesMedical conditionsLaboratory confirmationInfluenza Hospitalization Surveillance NetworkCommunity-onset casesInfluenza-related hospitalizationsPopulation-based surveillanceInfluenza hospitalizationsHospital admissionInfluenza seasonClinical outcomesMedian lengthInfluenza diagnosisSeasonal influenzaOverall epidemiologyHospitalizationPatientsInfluenzaAdmissionStaySurveillance networkGreater proportionEffect of the 2009 Influenza A(H1N1) Pandemic on Invasive Pneumococcal Pneumonia
Fleming-Dutra KE, Taylor T, Link-Gelles R, Garg S, Jhung MA, Finelli L, Jain S, Shay D, Chaves SS, Baumbach J, Hancock EB, Beall B, Bennett N, Zansky S, Petit S, Yousey-Hindes K, Farley MM, Gershman K, Harrison LH, Ryan P, Lexau C, Lynfield R, Reingold A, Schaffner W, Thomas A, Moore MR. Effect of the 2009 Influenza A(H1N1) Pandemic on Invasive Pneumococcal Pneumonia. The Journal Of Infectious Diseases 2013, 207: 1135-1143. PMID: 23303809, DOI: 10.1093/infdis/jit008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolConfidence IntervalsDatabases, FactualFemaleHospitalizationHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMaleMiddle AgedOdds RatioPandemicsPneumonia, PneumococcalPoisson DistributionPopulation SurveillanceRisk FactorsSeasonsSeverity of Illness IndexStreptococcus pneumoniaeUnited StatesYoung Adult
2012
Increase in Rates of Hospitalization Due to Laboratory-Confirmed Influenza Among Children and Adults During the 2009–10 Influenza Pandemic
Cox CM, D'Mello T, Perez A, Reingold A, Gershman K, Yousey-Hindes K, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Thomas A, Schaffner W, Finelli L, Network F. Increase in Rates of Hospitalization Due to Laboratory-Confirmed Influenza Among Children and Adults During the 2009–10 Influenza Pandemic. The Journal Of Infectious Diseases 2012, 206: 1350-1358. PMID: 23002448, DOI: 10.1093/infdis/jis517.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaPrevious influenza seasonRate of hospitalizationInfluenza seasonEmerging Infections Program NetworkInfections Program NetworkPopulation-based surveillancePandemic of influenzaAdult age groupsUS Census Bureau dataMean rateH1N1 infectionHospitalization DueHospitalization ratesIncidence rateInfluenza pandemicAge groupsHospitalizationInfluenzaMonthsCensus Bureau dataSurveillanceAdultsEpisodesChildrenReduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original ResearchInfluenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC
Luckhaupt SE, Sweeney MH, Funk R, Calvert GM, Nowell M, D'Mello T, Reingold A, Meek J, Yousey-Hindes K, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Jones T. Influenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 556-562. PMID: 22469504, PMCID: PMC3309704, DOI: 10.3201/eid1804.110337.Peer-Reviewed Original Research
2011
Description of Antiviral Treatment Among Adults Hospitalized With Influenza Before and During the 2009 Pandemic: United States, 2005–2009
Doshi S, Kamimoto L, Finelli L, Perez A, Reingold A, Gershman K, Yousey-Hindes K, Arnold K, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Bennett NM, Zansky S, Thomas A, Schaffner W, Fry AM. Description of Antiviral Treatment Among Adults Hospitalized With Influenza Before and During the 2009 Pandemic: United States, 2005–2009. The Journal Of Infectious Diseases 2011, 204: 1848-1856. PMID: 22013219, DOI: 10.1093/infdis/jir648.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmantadineAntiviral AgentsDrug Therapy, CombinationFemaleGuideline AdherenceHospitalizationHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMaleMiddle AgedOdds RatioOseltamivirPandemicsPractice Guidelines as TopicPractice Patterns, Physicians'PregnancyPregnancy Complications, InfectiousRimantadineUnited StatesYoung AdultZanamivirConceptsAntiviral treatmentPregnant womenHospitalized adultsActive population-based surveillanceEmerging Infections ProgramLaboratory-confirmed influenzaMedical record reviewPopulation-based surveillanceAntiviral recommendationsAntiviral useRecord reviewIllness onsetInfections ProgramInfluenza pandemicAntiviral agentsInfluenzaNegative predictorAdultsTreatmentWomenPandemicPatientsPregnancyCliniciansPersons
2009
Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study
Connally NP, Durante AJ, Yousey-Hindes KM, Meek JI, Nelson RS, Heimer R. Peridomestic Lyme Disease Prevention Results of a Population-Based Case–Control Study. American Journal Of Preventive Medicine 2009, 37: 201-206. PMID: 19595558, DOI: 10.1016/j.amepre.2009.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnimalsCase-Control StudiesChildChild, PreschoolConnecticutEnvironment DesignEnvironmental ExposureFemaleHumansHygieneInfantLogistic ModelsLyme DiseaseMaleMatched-Pair AnalysisMiddle AgedPopulation SurveillanceProspective StudiesResidence CharacteristicsRisk FactorsSurveys and QuestionnairesTicksYoung AdultConceptsCase-control studyLyme diseaseDisease prevention initiativesConditional logistic regressionDisease prevention measuresErythema migransPotential confoundersRecreational exposureLogistic regressionProspective ageDiseaseCase onsetPrevention resultsPrevention measuresPersonal protectionRiskHoursConfoundersMigransTicksInfectionStudyConnecticut communitiesMonths