2024
The burden of all-cause mortality following influenza-associated hospitalizations, FluSurv-NET, 2010-2019
O’Halloran A, Millman A, Holstein R, Olsen S, Cummings C, Chai S, Kirley P, Alden N, Yousey-Hindes K, Meek J, Openo K, Fawcett E, Ryan P, Leegwater L, Henderson J, McMahon M, Lynfield R, Angeles K, Bleecker M, McGuire S, Spina N, Tesini B, Gaitan M, Lung K, Shiltz E, Thomas A, Talbott H, Schaffner W, Hill M, Reed C, Garg S. The burden of all-cause mortality following influenza-associated hospitalizations, FluSurv-NET, 2010-2019. Clinical Infectious Diseases 2024, ciae547. PMID: 39495002, DOI: 10.1093/cid/ciae547.Peer-Reviewed Original ResearchInfluenza-associated hospitalizationsInfluenza-associated deathsIn-hospitalInfluenza Hospitalization Surveillance NetworkClinical characteristics of patientsHospital dischargeLaboratory-confirmed influenzaImpact of influenzaCharacteristics of patientsAll-cause mortalityMedical conditionsDied in-hospitalFluSurv-NETInfluenza hospitalizationsPost-discharge outcomesClinical characteristicsDeath certificatesOlder patientsPost-dischargeMedian daysPost-discharge deathsInfluenzaPatientsDays post-dischargeCardiovascular disease
2023
Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study
Sumner K, Masalovich S, O’Halloran A, Holstein R, Reingold A, Kirley P, Alden N, Herlihy R, Meek J, Yousey-Hindes K, Anderson E, Openo K, Monroe M, Leegwater L, Henderson J, Lynfield R, McMahon M, McMullen C, Angeles K, Spina N, Engesser K, Bennett N, Felsen C, Lung K, Shiltz E, Thomas A, Talbot H, Schaffner W, Swain A, George A, Rolfes M, Reed C, Garg S. Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study. The Lancet Microbe 2023, 4: e903-e912. PMID: 37769676, PMCID: PMC10872935, DOI: 10.1016/s2666-5247(23)00187-8.Peer-Reviewed Original ResearchConceptsInfluenza virus typeInfluenza-associated hospitalisationsInfluenza seasonInfluenza B virusICU admissionMechanical ventilationSevere outcomesOdds ratioVirus typeFluSurv-NETECMO useInfluenza vaccineB virusVirus infectionLaboratory-confirmed influenza virus infectionInfluenza Hospitalization Surveillance NetworkInfluenza B virus infectionPopulation-based surveillance systemComplete chart reviewEarly antiviral treatmentHospital-onset casesInfluenza-associated outcomesRepeated cross-sectional studyInfluenza vaccination statusB virus infection
2022
Drug use and severe outcomes among adults hospitalized with influenza, 2016–2019
Parisi C, Yousey‐Hindes K, Holstein R, O'Halloran A, Kirley P, Alden N, Anderson E, Kim S, McMahon M, Khanlian S, Spina N, Gaitan M, Shiltz E, Thomas A, Schaffner W, Talbot K, Crossland M, Cook R, Garg S, Meek J, Hadler J. Drug use and severe outcomes among adults hospitalized with influenza, 2016–2019. Influenza And Other Respiratory Viruses 2022, 17: e13052. PMID: 36300969, PMCID: PMC9835414, DOI: 10.1111/irv.13052.Peer-Reviewed Original ResearchConceptsSevere outcomesDrug useICU admissionMechanical ventilationInfluenza Hospitalization Surveillance NetworkInfluenza-associated outcomesSevere influenza outcomesPersistent public health problemChronic liver diseaseChronic lung diseasePublic health problemNon-Hispanic blacksLogistic regression modelsHispanics/LatinosSmoke tobaccoInfluenza vaccinationOpioid useImmunosuppressive conditionsInfluenza seasonSevere morbidityInfluenza infectionInfluenza outcomesLiver diseaseLung diseaseChronic conditionsEpidemiology, Clinical Characteristics, and Outcomes of Influenza-Associated Hospitalizations in US Children Over 9 Seasons Following the 2009 H1N1 Pandemic
Kamidani S, Garg S, Rolfes MA, Campbell AP, Cummings CN, Haston JC, Openo KP, Fawcett E, Chai SJ, Herlihy R, Yousey-Hindes K, Monroe ML, Kim S, Lynfield R, Smelser C, Muse A, Felsen CB, Billing L, Thomas A, Talbot HK, Schaffner W, Risk I, Anderson EJ. Epidemiology, Clinical Characteristics, and Outcomes of Influenza-Associated Hospitalizations in US Children Over 9 Seasons Following the 2009 H1N1 Pandemic. Clinical Infectious Diseases 2022, 75: 1930-1939. PMID: 35438769, DOI: 10.1093/cid/ciac296.Peer-Reviewed Original ResearchConceptsInfluenza Hospitalization Surveillance NetworkHospital mortality rateMechanical ventilationMortality rateIntensive care unit admissionRecent population-based dataCare unit admissionInfluenza vaccination ratesLaboratory-confirmed influenzaInfluenza-associated hospitalizationsMultivariable logistic regressionPopulation-based dataHospitalization incidence ratesMonths of ageUnit admissionAntiviral treatmentVaccination ratesRisk factorsIncidence rateHigher oddsUS childrenHospitalizationDisease controlLogistic regressionPneumonia
2021
Characteristics and Outcomes of Hospitalized Pregnant Women With Influenza, 2010 to 2019 : A Repeated Cross-Sectional Study.
Holstein R, Dawood FS, O'Halloran A, Cummings C, Ujamaa D, Daily Kirley P, Yousey-Hindes K, Fawcett E, Monroe ML, Kim S, Lynfield R, McMullen C, Muse A, Bennett NM, Billing LM, Sutton M, Thomas A, Talbot HK, Schaffner W, Risk I, Reed C, Garg S. Characteristics and Outcomes of Hospitalized Pregnant Women With Influenza, 2010 to 2019 : A Repeated Cross-Sectional Study. Annals Of Internal Medicine 2021, 175: 149-158. PMID: 34958603, DOI: 10.7326/m21-3668.Peer-Reviewed Original ResearchConceptsInfluenza-associated outcomesPregnant womenCross-sectional studyFetal outcomesHospital dischargeInfluenza seasonMechanical ventilationInfluenza Hospitalization Surveillance NetworkIntensive care unit admissionMedical chart abstractionRepeated cross-sectional studySevere maternal outcomesCare unit admissionLaboratory-confirmed influenzaReproductive-aged womenHospitalized pregnant womenInfluenza A H1N1Multivariable logistic regressionHigh-priority target groupUnit admissionHospital deathICU admissionMaternal outcomesChart abstractionClinical characteristicsInfluenza Antiviral Treatment and Length of Stay
Campbell AP, Tokars JI, Reynolds S, Garg S, Kirley PD, Miller L, Yousey-Hindes K, Anderson EJ, Oni O, Monroe M, Kim S, Lynfield R, Smelser C, Muse AT, Felsen C, Billing LM, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Fry AM. Influenza Antiviral Treatment and Length of Stay. Pediatrics 2021, 148: e2021050417. PMID: 34470815, DOI: 10.1542/peds.2021-050417.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaAntiviral treatmentMedical conditionsHospitalized patientsIllness onsetHigh-risk medical conditionsInfluenza Hospitalization Surveillance NetworkKaplan-Meier survival analysisEarly antiviral treatmentEmpiric antiviral treatmentInfluenza antiviral treatmentLength of stayHospital lengthICU cohortMedian LOSSymptom onsetShorter hospitalizationPrevention recommendationsTime-dependent variablesCox modelAntiviral agentsSurvival analysisCohortDisease controlInfluenza
2020
Acute Cardiovascular Events Associated With Influenza in Hospitalized Adults : A Cross-sectional Study.
Chow EJ, Rolfes MA, O'Halloran A, Anderson EJ, Bennett NM, Billing L, Chai S, Dufort E, Herlihy R, Kim S, Lynfield R, McMullen C, Monroe ML, Schaffner W, Spencer M, Talbot HK, Thomas A, Yousey-Hindes K, Reed C, Garg S. Acute Cardiovascular Events Associated With Influenza in Hospitalized Adults : A Cross-sectional Study. Annals Of Internal Medicine 2020, 173: 605-613. PMID: 32833488, PMCID: PMC8097760, DOI: 10.7326/m20-1509.Peer-Reviewed Original ResearchConceptsAcute ischemic heart diseaseAcute heart failureAcute cardiovascular eventsLaboratory-confirmed influenzaCardiovascular eventsCross-sectional studyInfluenza vaccinationDischarge codesInfluenza testingChronic conditionsTobacco useInfluenza Hospitalization Surveillance NetworkInfluenza antiviral medicationsMedical record abstractionIschemic heart diseasePopulation-based studyAnnual influenza epidemicsLogistic regression modelsCommon such eventsRace/ethnicityPractitioner ordersHospitalized adultsAntiviral medicationsHeart failureInfluenza seasonHospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020
Garg S, Kim L, Whitaker M, O’Halloran A, Cummings C, Holstein R, Prill M, Chai SJ, Kirley PD, Alden NB, Kawasaki B, Yousey-Hindes K, Niccolai L, Anderson EJ, Openo KP, Weigel A, Monroe ML, Ryan P, Henderson J, Kim S, Como-Sabetti K, Lynfield R, Sosin D, Torres S, Muse A, Bennett NM, Billing L, Sutton M, West N, Schaffner W, Talbot HK, Aquino C, George A, Budd A, Brammer L, Langley G, Hall AJ, Fry A. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020. MMWR Morbidity And Mortality Weekly Report 2020, 69: 458-464. PMID: 32298251, PMCID: PMC7755063, DOI: 10.15585/mmwr.mm6915e3.Peer-Reviewed Original ResearchCOVID-19-Associated Hospitalization Surveillance NetworkCOVID-19-associated hospitalizationUnderlying medical conditionsHospitalization ratesMedical conditionsOlder adultsLaboratory-confirmed COVID-19-associated hospitalizationsCOVID-19Influenza Hospitalization Surveillance NetworkSerious underlying medical conditionsHealth care system resourcesSurveillance networkCharacteristics of patientsChronic lung diseasePopulation-based surveillanceCoronavirus disease 2019SARS-CoV-2Majority of personsAdult patientsClinical characteristicsDiabetes mellitusClinical spectrumLung diseaseUnderlying conditionCardiovascular diseaseRespiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults
Chow EJ, Rolfes MA, O’Halloran A, Alden NB, Anderson EJ, Bennett NM, Billing L, Dufort E, Kirley PD, George A, Irizarry L, Kim S, Lynfield R, Ryan P, Schaffner W, Talbot HK, Thomas A, Yousey-Hindes K, Reed C, Garg S. Respiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults. JAMA Network Open 2020, 3: e201323. PMID: 32196103, PMCID: PMC7084169, DOI: 10.1001/jamanetworkopen.2020.1323.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaRespiratory diagnosesInfluenza seasonAcute diagnosisInfluenza Hospitalization Surveillance NetworkPositive influenza test resultsRevision discharge diagnosis codesSeasonal influenza virus infectionCommon acute diagnosesEarly antiviral treatmentAcute kidney injuryMedical record abstractionPatient demographic characteristicsDischarge diagnosis codesBurden of infectionInfluenza virus infectionInfluenza test resultsCross-sectional studyTranscription-polymerase chain reactionIndirect fluorescent stainingInternational Statistical ClassificationSurveillance networkRelated Health ProblemsFluSurv-NETHospital outcomesSpatial and temporal clustering of patients hospitalized with laboratory-confirmed influenza in the United States
Sloan C, Chandrasekhar R, Mitchel E, Ndi D, Miller L, Thomas A, Bennett NM, Chai S, Spencer M, Eckel S, Spina N, Monroe M, Anderson EJ, Lynfield R, Yousey-Hindes K, Bargsten M, Zansky S, Lung K, Schroeder M, N Cummings C, Garg S, Schaffner W, Lindegren ML. Spatial and temporal clustering of patients hospitalized with laboratory-confirmed influenza in the United States. Epidemics 2020, 31: 100387. PMID: 32371346, DOI: 10.1016/j.epidem.2020.100387.Peer-Reviewed Original ResearchConceptsRelative riskHospitalization burdenInfluenza Hospitalization Surveillance NetworkSocioeconomic factorsLaboratory-confirmed influenzaTiming of influenzaScan statistics analysisInfluenza seasonDisease burdenEpidemic timingSurveillance dataInfluenzaPandemic yearSpatial scan statisticSurveillance networkBurdenLocal socioeconomic factorsUnited StatesEpidemic intensityYearsPhase synchronyNational patternsPatientsSocioeconomicsFactors
2019
LB19. Patterns of Influenza A Hospitalizations by Subtype and Age in the United States, FluSurv-NET, 2018–2019
Garg S, O’Halloran A, O’Halloran A, Cummings C, Cummings C, Holstein R, Kniss K, Anderson E, Anderson E, Bennett N, Bennett N, Billing L, Billing L, Herlihy R, Hill M, Irizarry L, Irizarry L, Kim S, Kim S, Kirley P, Lynfield R, Lynfield R, Monroe M, Monroe M, Spina N, Talbot K, Talbot K, Thomas A, Thomas A, Yousey-Hindes K, Budd A, Brammer L, Reed C, Reed C. LB19. Patterns of Influenza A Hospitalizations by Subtype and Age in the United States, FluSurv-NET, 2018–2019. Open Forum Infectious Diseases 2019, 6: s1001-s1002. PMCID: PMC6810298, DOI: 10.1093/ofid/ofz415.2502.Peer-Reviewed Original ResearchProportion of casesAge groupsFluSurv-NETHospitalization ratesVirologic surveillanceInfluenza Hospitalization Surveillance NetworkUS Public Health LaboratoriesCumulative hospitalization rateDistribution of influenzaInfluenza hospitalization ratesLaboratory-confirmed influenzaYears of agePublic health laboratoriesInfluenza resultsH1N1pdm09 virusInfluenza vaccinationHospital admissionInfluenza seasonAge-related differencesInfluenza ASubtype distributionHospitalizationSanofi PasteurUnknown subtypeH1 virusesAge-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza—U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET)
Czaja CA, Miller L, Alden N, Wald HL, Cummings CN, Rolfes MA, Anderson EJ, Bennett NM, Billing LM, Chai SJ, Eckel S, Mansmann R, McMahon M, Monroe ML, Muse A, Risk I, Schaffner W, Thomas AR, Yousey-Hindes K, Garg S, Herlihy RK. Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza—U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET). Open Forum Infectious Diseases 2019, 6: ofz225. PMID: 31363771, PMCID: PMC6602897, DOI: 10.1093/ofid/ofz225.Peer-Reviewed Original ResearchLaboratory-confirmed influenzaInfluenza hospitalizationsAge-related differencesHospitalization ratesInfluenza seasonClinical presentationInfluenza Hospitalization Surveillance NetworkInfluenza-associated hospitalization ratesOlder adultsHospital deathHospitalized patientsMedical historyHigher oddsAge strataPatientsAge groupsHospitalizationTreatment effortsAdultsPopulation ratesSurveillance networkInfluenzaPresentationStepwise increaseAge
2018
2494. Influenza B Hospitalizations Are Associated With Mortality in Children, FluSurv-NET, 2011–2017
Garg S, O’Halloran A, Cummings C, Chai S, Alden N, Yousey-Hindes K, Anderson E, Ryan P, Collins J, Smelser C, Blog D, Felsen C, Billing L, Thomas A, Talbot H, Spencer M, Lynfield R, Reed C. 2494. Influenza B Hospitalizations Are Associated With Mortality in Children, FluSurv-NET, 2011–2017. Open Forum Infectious Diseases 2018, 5: s748-s749. PMCID: PMC6255344, DOI: 10.1093/ofid/ofy210.2146.Peer-Reviewed Original ResearchHospital mortalityUnivariate analysisVirus infectionInfluenza Hospitalization Surveillance NetworkInfluenza B virus infectionLaboratory-confirmed influenzaB virus infectionInfluenza-associated hospitalizationsMultivariable logistic regressionInfluenza B virusNon-Hispanic whitesCharacteristics of childrenClinical courseMedian ageMedical chartsMechanical ventilationIllness onsetIntensive careUnadjusted oddsHospitalized childrenB virusIndependent associationSevere outcomesNeurologic diseaseInfluenza typeClinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015
Collins JP, Campbell AP, Openo K, Farley MM, Cummings CN, Kirley PD, Herlihy R, Yousey-Hindes K, Monroe ML, Ladisky M, Lynfield R, Baumbach J, Spina N, Bennett N, Billing L, Thomas A, Schaffner W, Price A, Garg S, Anderson EJ. Clinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015. Journal Of The Pediatric Infectious Diseases Society 2018, 8: 539-549. PMID: 30358877, DOI: 10.1093/jpids/piy101.Peer-Reviewed Original ResearchConceptsSolid organ transplantationImmunocompromised childrenClinical featuresImmunosuppressive therapyIntensive careOrgan transplantationInfluenza Hospitalization Surveillance NetworkHuman immunodeficiency virus/Community-acquired influenzaEarly antiviral treatmentLonger hospitalization durationDuration of hospitalizationIntensive care admissionAntiviral useCare admissionHospital deathHospitalization durationInfluenza vaccinationAntiviral treatmentInfluenza seasonInfluenza severityPrimary outcomeImmunodeficiency syndromeMultivariable analysisImmunoglobulin deficiency
2016
Utility of Keywords from Chest Radiograph Reports for Pneumonia Surveillance among Hospitalized Patients with Influenza: The CDC Influenza Hospitalization Surveillance Network, 2008–2009
Bramley AM, Chaves SS, Dawood FS, Doshi S, Reingold A, Miller L, Yousey-Hindes K, Farley MM, Ryan P, Lynfield R, Baumbach J, Zansky S, Bennett N, Thomas A, Schaffner W, Finelli L, Jain S. Utility of Keywords from Chest Radiograph Reports for Pneumonia Surveillance among Hospitalized Patients with Influenza: The CDC Influenza Hospitalization Surveillance Network, 2008–2009. Public Health Reports 2016, 131: 483-490. PMID: 27252568, PMCID: PMC4869084, DOI: 10.1177/003335491613100314.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenza virus infectionInfluenza virus infectionPositive predictive valueChest radiograph reportsVirus infectionPercent agreementPneumonia surveillanceRadiograph reportsInfluenza Hospitalization Surveillance NetworkAdmission chest radiographsClinical Modification codesAbsence of pneumoniaDischarge summary dataComposite reference standardCohen's K statisticPublic health responsePublic health surveillanceU.S. study sitesStaff membersHospitalized patientsPleural effusionNinth RevisionPneumonia casesChest radiographsK statisticSurvey of influenza and other respiratory viruses diagnostic testing in US hospitals, 2012–2013
Su S, Fry AM, Kirley PD, Aragon D, Yousey‐Hindes K, Meek J, Openo K, Oni O, Sharangpani R, Morin C, Hollick G, Lung K, Laidler M, Lindegren ML, Schaffner W, Atkinson A, Chaves SS. Survey of influenza and other respiratory viruses diagnostic testing in US hospitals, 2012–2013. Influenza And Other Respiratory Viruses 2016, 10: 86-90. PMID: 26505742, PMCID: PMC4746564, DOI: 10.1111/irv.12355.Peer-Reviewed Original ResearchConceptsInfluenza Hospitalization Surveillance NetworkRespiratory virusesAvailable rapid influenza diagnostic testsRapid influenza diagnostic testsInfluenza diagnostic testsOptimal clinical managementInfection control practitionersSurvey of hospitalsDetection of influenzaSurveillance networkInfluenza infectionClinical managementCatchment populationStandardized questionnaireUS hospitalsHospitalDiagnostic testingInfluenzaLaboratory capacityTelephone interviewsDiagnostic testsMolecular diagnostic assaysInsensitive assayControl practitionersDiagnostic practice
2013
Hospital-onset influenza hospitalizations—United States, 2010-2011
Jhung MA, D'Mello T, Pérez A, Aragon D, Bennett NM, Cooper T, Farley MM, Fowler B, Grube SM, Hancock EB, Lynfield R, Morin C, Reingold A, Ryan P, Schaffner W, Sharangpani R, Tengelsen L, Thomas A, Thurston D, Yousey-Hindes K, Zansky S, Finelli L, Chaves SS. Hospital-onset influenza hospitalizations—United States, 2010-2011. American Journal Of Infection Control 2013, 42: 7-11. PMID: 24183534, DOI: 10.1016/j.ajic.2013.06.018.Peer-Reviewed Original ResearchConceptsIntensive care unitChronic medical conditionsCare unitHO casesMedical conditionsLaboratory confirmationInfluenza Hospitalization Surveillance NetworkCommunity-onset casesInfluenza-related hospitalizationsPopulation-based surveillanceInfluenza hospitalizationsHospital admissionInfluenza seasonClinical outcomesMedian lengthInfluenza diagnosisSeasonal influenzaOverall epidemiologyHospitalizationPatientsInfluenzaAdmissionStaySurveillance networkGreater proportion