2024
The burden of all-cause mortality following influenza-associated hospitalizations, FluSurv-NET, 2010-2019
O’Halloran A, Millman A, Holstein R, Olsen S, Cummings C, Chai S, Kirley P, Alden N, Yousey-Hindes K, Meek J, Openo K, Fawcett E, Ryan P, Leegwater L, Henderson J, McMahon M, Lynfield R, Angeles K, Bleecker M, McGuire S, Spina N, Tesini B, Gaitan M, Lung K, Shiltz E, Thomas A, Talbott H, Schaffner W, Hill M, Reed C, Garg S. The burden of all-cause mortality following influenza-associated hospitalizations, FluSurv-NET, 2010-2019. Clinical Infectious Diseases 2024, ciae547. PMID: 39495002, DOI: 10.1093/cid/ciae547.Peer-Reviewed Original ResearchInfluenza-associated hospitalizationsInfluenza-associated deathsIn-hospitalInfluenza Hospitalization Surveillance NetworkClinical characteristics of patientsHospital dischargeLaboratory-confirmed influenzaImpact of influenzaCharacteristics of patientsAll-cause mortalityMedical conditionsDied in-hospitalFluSurv-NETInfluenza hospitalizationsPost-discharge outcomesClinical characteristicsDeath certificatesOlder patientsPost-dischargeMedian daysPost-discharge deathsInfluenzaPatientsDays post-dischargeCardiovascular disease
2022
Influenza Antiviral Use in Patients Hospitalized With Laboratory-Confirmed Influenza in the United States, FluSurv-NET, 2015–2019
Tenforde M, Cummings C, O’Halloran A, Rothrock G, Kirley P, Alden N, Meek J, Yousey-Hindes K, Openo K, Anderson E, Monroe M, Kim S, Nunez V, McMahon M, McMullen C, Khanlian S, Spina N, Muse A, Gaitán M, Felsen C, Lung K, Shiltz E, Sutton M, Thomas A, Talbot H, Schaffner W, Price A, Chatelain R, Reed C, Garg S. Influenza Antiviral Use in Patients Hospitalized With Laboratory-Confirmed Influenza in the United States, FluSurv-NET, 2015–2019. Open Forum Infectious Diseases 2022, 10: ofac681. PMID: 36686630, PMCID: PMC9846184, DOI: 10.1093/ofid/ofac681.Peer-Reviewed Original Research
2021
Influenza Antiviral Treatment and Length of Stay
Campbell AP, Tokars JI, Reynolds S, Garg S, Kirley PD, Miller L, Yousey-Hindes K, Anderson EJ, Oni O, Monroe M, Kim S, Lynfield R, Smelser C, Muse AT, Felsen C, Billing LM, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Fry AM. Influenza Antiviral Treatment and Length of Stay. Pediatrics 2021, 148: e2021050417. PMID: 34470815, DOI: 10.1542/peds.2021-050417.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaAntiviral treatmentMedical conditionsHospitalized patientsIllness onsetHigh-risk medical conditionsInfluenza Hospitalization Surveillance NetworkKaplan-Meier survival analysisEarly antiviral treatmentEmpiric antiviral treatmentInfluenza antiviral treatmentLength of stayHospital lengthICU cohortMedian LOSSymptom onsetShorter hospitalizationPrevention recommendationsTime-dependent variablesCox modelAntiviral agentsSurvival analysisCohortDisease controlInfluenza
2020
Spatial and temporal clustering of patients hospitalized with laboratory-confirmed influenza in the United States
Sloan C, Chandrasekhar R, Mitchel E, Ndi D, Miller L, Thomas A, Bennett NM, Chai S, Spencer M, Eckel S, Spina N, Monroe M, Anderson EJ, Lynfield R, Yousey-Hindes K, Bargsten M, Zansky S, Lung K, Schroeder M, N Cummings C, Garg S, Schaffner W, Lindegren ML. Spatial and temporal clustering of patients hospitalized with laboratory-confirmed influenza in the United States. Epidemics 2020, 31: 100387. PMID: 32371346, DOI: 10.1016/j.epidem.2020.100387.Peer-Reviewed Original ResearchConceptsRelative riskHospitalization burdenInfluenza Hospitalization Surveillance NetworkSocioeconomic factorsLaboratory-confirmed influenzaTiming of influenzaScan statistics analysisInfluenza seasonDisease burdenEpidemic timingSurveillance dataInfluenzaPandemic yearSpatial scan statisticSurveillance networkBurdenLocal socioeconomic factorsUnited StatesEpidemic intensityYearsPhase synchronyNational patternsPatientsSocioeconomicsFactors
2019
Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza—U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET)
Czaja CA, Miller L, Alden N, Wald HL, Cummings CN, Rolfes MA, Anderson EJ, Bennett NM, Billing LM, Chai SJ, Eckel S, Mansmann R, McMahon M, Monroe ML, Muse A, Risk I, Schaffner W, Thomas AR, Yousey-Hindes K, Garg S, Herlihy RK. Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza—U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET). Open Forum Infectious Diseases 2019, 6: ofz225. PMID: 31363771, PMCID: PMC6602897, DOI: 10.1093/ofid/ofz225.Peer-Reviewed Original ResearchLaboratory-confirmed influenzaInfluenza hospitalizationsAge-related differencesHospitalization ratesInfluenza seasonClinical presentationInfluenza Hospitalization Surveillance NetworkInfluenza-associated hospitalization ratesOlder adultsHospital deathHospitalized patientsMedical historyHigher oddsAge strataPatientsAge groupsHospitalizationTreatment effortsAdultsPopulation ratesSurveillance networkInfluenzaPresentationStepwise increaseAgeEffects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season
Rolfes MA, Flannery B, Chung JR, O’Halloran A, Garg S, Belongia EA, Gaglani M, Zimmerman RK, Jackson ML, Monto AS, Alden NB, Anderson E, Bennett NM, Billing L, Eckel S, Kirley PD, Lynfield R, Monroe ML, Spencer M, Spina N, Talbot HK, Thomas A, Torres SM, Yousey-Hindes K, Singleton JA, Patel M, Reed C, Fry AM, McLean H, King J, Nowalk M, Balasubramani G, Bear T, Hickey R, Williams J, Reis E, Moehling K, Eng H, Jackson L, Smith M, Raiyani C, Clipper L, Murthy K, Chen W, Reis M, Petrie J, Malosh R, McSpadden E, Segaloff H, Cheng C, Truscon R, Johnson E, Lamerato L, Rosenblum B, Ford S, Johnson M, Raviotta J, Sax T, Steele J, Susick M, Chabra R, Garofolo E, Iozzi P, Kevish B, Middleton D, Urbanski L, Ponder T, Crumbaker T, Iosefo I, Sleeth P, Gandy V, Bounds K, Kylberg M, Rao A, Fader R, Walker K, Volz M, Ray J, Price D, Thomas J, Wehbe-Janek H, Beeram M, Boyd J, Walkowiak J, Probe R, Couchman G, Motakef S, Arroliga A, Kaniclides A, Bouldin E, Baker C, Berke K, Smith M, Rajesh N, Alleman E, Bauer S, Groesbeck M, Brundidge K, Hafeez N, Jackson J, Anastasia I, Kadoo G, Petnic S, Ryan A, Maslar A, Meek J, Chen R, Stephens S, Thomas S, Segler S, Openo K, Fawcett E, Farley M, Martin A, Ryan P, Sunkel R, Lutich T, Perlmutter R, Grace B, Blood T, Zerrlaut C, McMahon M, Strain A, Christensen J, Angeles K, Butler L, Khanlian S, Mansmann R, McMullen C, Pradhan E, Manzi K, Felsen C, Gaitan M, Long K, Fisher N, Hawley E, O’Shaughnessy R, Scott M, Crawford C, Schaffner W, Markus T, Leib K, Dyer K, Santibanez T, Zhai Y, Lu P, Srivastav A, Hung M. Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season. Clinical Infectious Diseases 2019, 69: 1845-1853. PMID: 30715278, PMCID: PMC7188082, DOI: 10.1093/cid/ciz075.Peer-Reviewed Original ResearchConceptsInfluenza-associated illnessVaccine effectivenessInfluenza vaccinationInfluenza seasonMedical visitsCurrent influenza vaccinationInfluenza-associated outcomesInfluenza vaccine coverageInfluenza vaccine effectivenessLaboratory-confirmed influenzaTest-negative designInfluenza virus infectionAge-specific estimatesInfluenza B.Vaccine coverageDisease burdenVirus infectionSubstantial burdenAmbulatory settingVaccinationHospitalizationImproved vaccinesInfluenzaIllnessVisits
2016
Survey of influenza and other respiratory viruses diagnostic testing in US hospitals, 2012–2013
Su S, Fry AM, Kirley PD, Aragon D, Yousey‐Hindes K, Meek J, Openo K, Oni O, Sharangpani R, Morin C, Hollick G, Lung K, Laidler M, Lindegren ML, Schaffner W, Atkinson A, Chaves SS. Survey of influenza and other respiratory viruses diagnostic testing in US hospitals, 2012–2013. Influenza And Other Respiratory Viruses 2016, 10: 86-90. PMID: 26505742, PMCID: PMC4746564, DOI: 10.1111/irv.12355.Peer-Reviewed Original ResearchConceptsInfluenza Hospitalization Surveillance NetworkRespiratory virusesAvailable rapid influenza diagnostic testsRapid influenza diagnostic testsInfluenza diagnostic testsOptimal clinical managementInfection control practitionersSurvey of hospitalsDetection of influenzaSurveillance networkInfluenza infectionClinical managementCatchment populationStandardized questionnaireUS hospitalsHospitalDiagnostic testingInfluenzaLaboratory capacityTelephone interviewsDiagnostic testsMolecular diagnostic assaysInsensitive assayControl practitionersDiagnostic practice
2015
Does Influenza Vaccination Modify Influenza Disease Severity? Data on Adults Hospitalized With Influenza During the 2013–14 Season in the United States
Arriola C, Anderson E, Bargsten M, Bohm S, Lindegren M, Lung K, Lynfield R, Miller L, Monroe M, Reingold A, Thomas A, Yousey-Hindes K, Dos Santos Chaves S. Does Influenza Vaccination Modify Influenza Disease Severity? Data on Adults Hospitalized With Influenza During the 2013–14 Season in the United States. Open Forum Infectious Diseases 2015, 2: 1353. DOI: 10.1093/ofid/ofv131.144.Peer-Reviewed Original Research
2013
Heavy alcohol use as a risk factor for severe outcomes among adults hospitalized with laboratory-confirmed influenza, 2005–2012
Greenbaum A, Chaves S, Perez A, Aragon D, Bandyopadhyay A, Bennett N, Fowler B, Hancock E, Lynfield R, McDonald-Hamm C, Reingold A, Ryan P, Schaffner W, Sharangpani R, Spencer M, Thomas A, Yousey-Hindes K, Zansky S, Finelli L. Heavy alcohol use as a risk factor for severe outcomes among adults hospitalized with laboratory-confirmed influenza, 2005–2012. Infection 2013, 42: 165-170. PMID: 24243481, DOI: 10.1007/s15010-013-0534-8.Peer-Reviewed Original ResearchHospital-onset influenza hospitalizations—United States, 2010-2011
Jhung MA, D'Mello T, Pérez A, Aragon D, Bennett NM, Cooper T, Farley MM, Fowler B, Grube SM, Hancock EB, Lynfield R, Morin C, Reingold A, Ryan P, Schaffner W, Sharangpani R, Tengelsen L, Thomas A, Thurston D, Yousey-Hindes K, Zansky S, Finelli L, Chaves SS. Hospital-onset influenza hospitalizations—United States, 2010-2011. American Journal Of Infection Control 2013, 42: 7-11. PMID: 24183534, DOI: 10.1016/j.ajic.2013.06.018.Peer-Reviewed Original ResearchConceptsIntensive care unitChronic medical conditionsCare unitHO casesMedical conditionsLaboratory confirmationInfluenza Hospitalization Surveillance NetworkCommunity-onset casesInfluenza-related hospitalizationsPopulation-based surveillanceInfluenza hospitalizationsHospital admissionInfluenza seasonClinical outcomesMedian lengthInfluenza diagnosisSeasonal influenzaOverall epidemiologyHospitalizationPatientsInfluenzaAdmissionStaySurveillance networkGreater proportionEffect of the 2009 Influenza A(H1N1) Pandemic on Invasive Pneumococcal Pneumonia
Fleming-Dutra KE, Taylor T, Link-Gelles R, Garg S, Jhung MA, Finelli L, Jain S, Shay D, Chaves SS, Baumbach J, Hancock EB, Beall B, Bennett N, Zansky S, Petit S, Yousey-Hindes K, Farley MM, Gershman K, Harrison LH, Ryan P, Lexau C, Lynfield R, Reingold A, Schaffner W, Thomas A, Moore MR. Effect of the 2009 Influenza A(H1N1) Pandemic on Invasive Pneumococcal Pneumonia. The Journal Of Infectious Diseases 2013, 207: 1135-1143. PMID: 23303809, DOI: 10.1093/infdis/jit008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildChild, PreschoolConfidence IntervalsDatabases, FactualFemaleHospitalizationHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMaleMiddle AgedOdds RatioPandemicsPneumonia, PneumococcalPoisson DistributionPopulation SurveillanceRisk FactorsSeasonsSeverity of Illness IndexStreptococcus pneumoniaeUnited StatesYoung Adult
2012
Increase in Rates of Hospitalization Due to Laboratory-Confirmed Influenza Among Children and Adults During the 2009–10 Influenza Pandemic
Cox CM, D'Mello T, Perez A, Reingold A, Gershman K, Yousey-Hindes K, Arnold KE, Farley MM, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Thomas A, Schaffner W, Finelli L, Network F. Increase in Rates of Hospitalization Due to Laboratory-Confirmed Influenza Among Children and Adults During the 2009–10 Influenza Pandemic. The Journal Of Infectious Diseases 2012, 206: 1350-1358. PMID: 23002448, DOI: 10.1093/infdis/jis517.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaPrevious influenza seasonRate of hospitalizationInfluenza seasonEmerging Infections Program NetworkInfections Program NetworkPopulation-based surveillancePandemic of influenzaAdult age groupsUS Census Bureau dataMean rateH1N1 infectionHospitalization DueHospitalization ratesIncidence rateInfluenza pandemicAge groupsHospitalizationInfluenzaMonthsCensus Bureau dataSurveillanceAdultsEpisodesChildrenReduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic
Garg S, Chaves SS, Pérez A, D'Mello T, Gershman K, Meek J, Yousey-Hindes K, Arnold KE, Farley MM, Tengelsen L, Ryan P, Sharangpani R, Lynfield R, Morin C, Baumbach J, Hancock EB, Zansky S, Bennett NM, Fowler B, Bradley K, Thomas A, Cooper T, Schaffner W, Boulton R, Finelli L, Fry AM. Reduced Influenza Antiviral Treatment Among Children and Adults Hospitalized With Laboratory-Confirmed Influenza Infection in the Year After the 2009 Pandemic. Clinical Infectious Diseases 2012, 55: e18-e21. PMID: 22543024, DOI: 10.1093/cid/cis442.Peer-Reviewed Original ResearchInfluenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC
Luckhaupt SE, Sweeney MH, Funk R, Calvert GM, Nowell M, D'Mello T, Reingold A, Meek J, Yousey-Hindes K, Arnold KE, Ryan P, Lynfield R, Morin C, Baumbach J, Zansky S, Bennett NM, Thomas A, Schaffner W, Jones T. Influenza-associated Hospitalizations by Industry, 2009–10 Influenza Season, United States - Volume 18, Number 4—April 2012 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2012, 18: 556-562. PMID: 22469504, PMCID: PMC3309704, DOI: 10.3201/eid1804.110337.Peer-Reviewed Original Research
2011
Description of Antiviral Treatment Among Adults Hospitalized With Influenza Before and During the 2009 Pandemic: United States, 2005–2009
Doshi S, Kamimoto L, Finelli L, Perez A, Reingold A, Gershman K, Yousey-Hindes K, Arnold K, Ryan P, Lynfield R, Morin C, Baumbach J, Hancock EB, Bennett NM, Zansky S, Thomas A, Schaffner W, Fry AM. Description of Antiviral Treatment Among Adults Hospitalized With Influenza Before and During the 2009 Pandemic: United States, 2005–2009. The Journal Of Infectious Diseases 2011, 204: 1848-1856. PMID: 22013219, DOI: 10.1093/infdis/jir648.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmantadineAntiviral AgentsDrug Therapy, CombinationFemaleGuideline AdherenceHospitalizationHumansInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMaleMiddle AgedOdds RatioOseltamivirPandemicsPractice Guidelines as TopicPractice Patterns, Physicians'PregnancyPregnancy Complications, InfectiousRimantadineUnited StatesYoung AdultZanamivirConceptsAntiviral treatmentPregnant womenHospitalized adultsActive population-based surveillanceEmerging Infections ProgramLaboratory-confirmed influenzaMedical record reviewPopulation-based surveillanceAntiviral recommendationsAntiviral useRecord reviewIllness onsetInfections ProgramInfluenza pandemicAntiviral agentsInfluenzaNegative predictorAdultsTreatmentWomenPandemicPatientsPregnancyCliniciansPersons