2023
Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study
Sumner K, Masalovich S, O’Halloran A, Holstein R, Reingold A, Kirley P, Alden N, Herlihy R, Meek J, Yousey-Hindes K, Anderson E, Openo K, Monroe M, Leegwater L, Henderson J, Lynfield R, McMahon M, McMullen C, Angeles K, Spina N, Engesser K, Bennett N, Felsen C, Lung K, Shiltz E, Thomas A, Talbot H, Schaffner W, Swain A, George A, Rolfes M, Reed C, Garg S. Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010–19: a repeated cross-sectional study. The Lancet Microbe 2023, 4: e903-e912. PMID: 37769676, PMCID: PMC10872935, DOI: 10.1016/s2666-5247(23)00187-8.Peer-Reviewed Original ResearchConceptsInfluenza virus typeInfluenza-associated hospitalisationsInfluenza seasonInfluenza B virusICU admissionMechanical ventilationSevere outcomesOdds ratioVirus typeFluSurv-NETECMO useInfluenza vaccineB virusVirus infectionLaboratory-confirmed influenza virus infectionInfluenza Hospitalization Surveillance NetworkInfluenza B virus infectionPopulation-based surveillance systemComplete chart reviewEarly antiviral treatmentHospital-onset casesInfluenza-associated outcomesRepeated cross-sectional studyInfluenza vaccination statusB virus infection
2021
Influenza Antiviral Treatment and Length of Stay
Campbell AP, Tokars JI, Reynolds S, Garg S, Kirley PD, Miller L, Yousey-Hindes K, Anderson EJ, Oni O, Monroe M, Kim S, Lynfield R, Smelser C, Muse AT, Felsen C, Billing LM, Thomas A, Mermel E, Lindegren ML, Schaffner W, Price A, Fry AM. Influenza Antiviral Treatment and Length of Stay. Pediatrics 2021, 148: e2021050417. PMID: 34470815, DOI: 10.1542/peds.2021-050417.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaAntiviral treatmentMedical conditionsHospitalized patientsIllness onsetHigh-risk medical conditionsInfluenza Hospitalization Surveillance NetworkKaplan-Meier survival analysisEarly antiviral treatmentEmpiric antiviral treatmentInfluenza antiviral treatmentLength of stayHospital lengthICU cohortMedian LOSSymptom onsetShorter hospitalizationPrevention recommendationsTime-dependent variablesCox modelAntiviral agentsSurvival analysisCohortDisease controlInfluenza
2020
Respiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults
Chow EJ, Rolfes MA, O’Halloran A, Alden NB, Anderson EJ, Bennett NM, Billing L, Dufort E, Kirley PD, George A, Irizarry L, Kim S, Lynfield R, Ryan P, Schaffner W, Talbot HK, Thomas A, Yousey-Hindes K, Reed C, Garg S. Respiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults. JAMA Network Open 2020, 3: e201323. PMID: 32196103, PMCID: PMC7084169, DOI: 10.1001/jamanetworkopen.2020.1323.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaRespiratory diagnosesInfluenza seasonAcute diagnosisInfluenza Hospitalization Surveillance NetworkPositive influenza test resultsRevision discharge diagnosis codesSeasonal influenza virus infectionCommon acute diagnosesEarly antiviral treatmentAcute kidney injuryMedical record abstractionPatient demographic characteristicsDischarge diagnosis codesBurden of infectionInfluenza virus infectionInfluenza test resultsCross-sectional studyTranscription-polymerase chain reactionIndirect fluorescent stainingInternational Statistical ClassificationSurveillance networkRelated Health ProblemsFluSurv-NETHospital outcomes
2018
Clinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015
Collins JP, Campbell AP, Openo K, Farley MM, Cummings CN, Kirley PD, Herlihy R, Yousey-Hindes K, Monroe ML, Ladisky M, Lynfield R, Baumbach J, Spina N, Bennett N, Billing L, Thomas A, Schaffner W, Price A, Garg S, Anderson EJ. Clinical Features and Outcomes of Immunocompromised Children Hospitalized With Laboratory-Confirmed Influenza in the United States, 2011–2015. Journal Of The Pediatric Infectious Diseases Society 2018, 8: 539-549. PMID: 30358877, DOI: 10.1093/jpids/piy101.Peer-Reviewed Original ResearchConceptsSolid organ transplantationImmunocompromised childrenClinical featuresImmunosuppressive therapyIntensive careOrgan transplantationInfluenza Hospitalization Surveillance NetworkHuman immunodeficiency virus/Community-acquired influenzaEarly antiviral treatmentLonger hospitalization durationDuration of hospitalizationIntensive care admissionAntiviral useCare admissionHospital deathHospitalization durationInfluenza vaccinationAntiviral treatmentInfluenza seasonInfluenza severityPrimary outcomeImmunodeficiency syndromeMultivariable analysisImmunoglobulin deficiency