2020
Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial.
Dias de Oliveira R, da Silva Santos A, Reis C, de Cássia Leite A, Correia Sacchi F, de Araujo R, Dos Santos P, Rolla V, Martinez L, Andrews J, Croda J. Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial. American Journal Of Tropical Medicine And Hygiene 2020, 103: 1466-1472. PMID: 32876010, PMCID: PMC7543866, DOI: 10.4269/ajtmh.20-0110.Peer-Reviewed Original ResearchConceptsQFT conversionTB infectionSecondary outcomesPlacebo-controlled trialQuantiFERON-TB GoldFuture clinical trialsPrimary prophylaxisMiddle-income countriesPrimary outcomeTuberculosis infectionIntervention armTuberculosis incidenceControl armTrial protocolClinical trialsElevated riskInterim analysisLatent infectionCutoff pointInfectionTrialsHigher cutoffSustained conversionInternational unitsLower rates
2015
Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study
Carbone Ada S, Paião DS, Sgarbi RV, Lemos EF, Cazanti RF, Ota MM, Junior AL, Bampi JV, Elias VP, Simionatto S, Motta-Castro AR, Pompílio MA, de Oliveira SM, Ko AI, Andrews JR, Croda J. Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study. BMC Infectious Diseases 2015, 15: 24. PMID: 25608746, PMCID: PMC4307675, DOI: 10.1186/s12879-015-0764-8.Peer-Reviewed Original ResearchConceptsLatent tuberculosis infectionPrevalence of LTBITuberculin skin testActive TBLTBI prevalenceWeeks of symptomsHigh transmission settingsCross-sectional studyPopulation-based samplePoisson regression modelsDuration of incarcerationHierarchical Poisson regression modelActive diseaseTB infectionLatent tuberculosisTB casesHIV testingSputum cultureTuberculosis infectionPoint prevalenceSkin testTuberculosis incidenceRisk factorsMultivariable modelSputum samples
2013
Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
Longhi R, Zembrzuski V, Basta P, Croda J. Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review. The Brazilian Journal Of Infectious Diseases 2013, 17: 363-368. PMID: 23665009, PMCID: PMC9427389, DOI: 10.1016/j.bjid.2012.11.001.Peer-Reviewed Original ResearchConceptsImmune responseCytokine expressionGenetic polymorphismsHigher IL-5 productionTh2-type responseIL-5 productionTuberculin skin testIFN-γ productionRelevant genetic polymorphismsActive diseaseTB infectionCytokine levelsLower TNFHigh IgG4IgM levelsIL-12p40Skin testImmunogenetic mechanismsImmune regulationInclusion criteriaNew treatmentsMajority of studiesTuberculosisSearch termsIndigenous populationsSugar cane manufacturing is associated with tuberculosis in an indigenous population in Brazil
Sacchi FP, Croda MG, Estevan AO, Ko AI, Croda J. Sugar cane manufacturing is associated with tuberculosis in an indigenous population in Brazil. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 2013, 107: 152-157. PMID: 23306443, DOI: 10.1093/trstmh/trs089.Peer-Reviewed Original ResearchConceptsCause of morbidityCase-control studySpecific epidemiological conditionsTB contactTB infectionTuberculosis infectionAnnual incidenceTuberculosis casesMale genderRisk factorsDisease surveillance programsMultivariate analysisTuberculosisDisease controlSurveillance programControl casesIndigenous populationsEpidemiological conditionsInfectionPotential relationshipPopulationNational disease surveillance programmeMorbidityMortalityIncidence