2021
The somatic molecular evolution of cancer: Mutation, selection, and epistasis
Dasari K, Somarelli JA, Kumar S, Townsend JP. The somatic molecular evolution of cancer: Mutation, selection, and epistasis. Progress In Biophysics And Molecular Biology 2021, 165: 56-65. PMID: 34364910, PMCID: PMC8819680, DOI: 10.1016/j.pbiomolbio.2021.08.003.Peer-Reviewed Original ResearchConceptsCancer evolutionEpistatic interactionsNeutral mutation rateCancer progressionEvolution of neoplasmsSingle nucleotide variantsMolecular evolutionRate of fixationGenetic interactionsEvolutionary biologyPhylogenetic analysisCopy number aberrationsPhylogenetic relationsNeutral mutationsGenomic dataSelective pressureSynonymous mutationsMutation rateChromosomal instabilityPhenotypic changesLoss of heterozygosityFitness landscapeClonal deconvolutionTumor microenvironmentEnvironment interaction
2017
Chapter One Maximizing Power in Phylogenetics and Phylogenomics: A Perspective Illuminated by Fungal Big Data
Dornburg A, Townsend JP, Wang Z. Chapter One Maximizing Power in Phylogenetics and Phylogenomics: A Perspective Illuminated by Fungal Big Data. Advances In Genetics 2017, 100: 1-47. PMID: 29153398, DOI: 10.1016/bs.adgen.2017.09.007.ChaptersConceptsTree of lifeFungal evolutionary biologyGenomic-scale dataHundreds of lociGenome-scale analysisFungal phylogenomicsFungal treeSpecies delimitationPhenotypic diversificationFirst genomeEvolutionary biologyPhylogenetic treePhylogenetic inferencePhylogenetic analysisEntire genomeTree inferenceReview of considerationsEvolutionary problemsPhylogenomicsGenomeTreesLociCentral roleExperimental designBiodiversity
2016
Future Perspectives and Challenges of Fungal Systematics in the Age of Big Data
Wang Z, Nilsson R, James T, Dai Y, Townsend J. Future Perspectives and Challenges of Fungal Systematics in the Age of Big Data. Fungal Biology 2016, 25-46. DOI: 10.1007/978-3-319-29137-6_3.ChaptersFungal systematicsMolecular phylogenyEnvironmental DNA surveysHigh-throughput sequencingSequence-based classificationFungal treeFungal evolutionPhylogenetic informativenessFungal genomesIntegrative taxonomyDNA surveysFungal researchEvolutionary biologyPhylogenetic inferenceComparative biologyTaxonomic ranksEcological charactersFungal classificationInformative experimental designGenetic markersMycological researchPhylogenySanger sequencingSystematicsBiology
2015
Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola
Sistrom M, Park D, O’Brien H, Wang Z, Guttman DS, Townsend JP, Turner PE. Genomic and Gene-Expression Comparisons among Phage-Resistant Type-IV Pilus Mutants of Pseudomonas syringae pathovar phaseolicola. PLOS ONE 2015, 10: e0144514. PMID: 26670219, PMCID: PMC4687649, DOI: 10.1371/journal.pone.0144514.Peer-Reviewed Original ResearchConceptsGene OntologyGene expression variationType IV pilus expressionGene expression comparisonsType IV piliTricarboxylic acid cycle (TCA) cycleType IV pilusNon-piliated strainsPseudomonas syringae pathovar phaseolicolaAcetyl-CoA metabolismEvolutionary biologyTCA pathwayExpression analysisPilus retractionPilus mutantsExpression variationExpression patternsWild typeAerobic respirationGenome sequencingSignificant bacterial pathogensPilus expressionDifferential expressionBacterial cellsPathovar phaseolicola
2005
Horizontal gene transfer, genome innovation and evolution
Gogarten JP, Townsend JP. Horizontal gene transfer, genome innovation and evolution. Nature Reviews Microbiology 2005, 3: 679-687. PMID: 16138096, DOI: 10.1038/nrmicro1204.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHorizontal gene transferHGT eventsImportance of HGTLife historyConcatenation of genesGene transferTypes of genesGroups of organismsGene historiesReticulation eventsPhylogenetic signalTaxonomic samplingMicrobial evolutionSelective sweepsGenome innovationPhylogenetic reconstructionEvolutionary biologyProkaryotic genomesSuch genesMicrobial communitiesPhylogenetic analysisGene swappingHorizontal transferTaxonomic classificationGenes
2000
Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis
Cavalieri D, Townsend J, Hartl D. Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 12369-12374. PMID: 11035792, PMCID: PMC17348, DOI: 10.1073/pnas.210395297.Peer-Reviewed Original ResearchConceptsDNA microarray analysisGene expressionNatural populationsSaccharomyces cerevisiaeMicroarray analysisGenome-wide transcriptional profilingAmino acid permeasesAmino acid biosynthesisSuite of traitsGlobal expression analysisSmooth colony phenotypeExtent of heterozygosityGlobal patternsVineyard isolateGene functionEvolutionary biologyNitrogen assimilationAcid biosynthesisSingle geneTranscriptional profilingUnlinked lociColony phenotypeHomothallic strainsS. cerevisiaeDiploid progeny