2021
Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials
Wessells K, Arnold C, Stewart C, Prado E, Abbeddou S, Adu-Afarwuah S, Arnold B, Ashorn P, Ashorn U, Becquey E, Brown K, Byrd K, Campbell R, Christian P, Fernald L, Fan Y, Galasso E, Hess S, Huybregts L, Jorgensen J, Kiprotich M, Kortekangas E, Lartey A, Le Port A, Leroy J, Lin A, Maleta K, Matias S, Mbuya M, Mridha M, Mutasa K, Naser A, Paul R, Okronipa H, Ouédraogo J, Pickering A, Rahman M, Schulze K, Smith L, Weber A, Zongrone A, Dewey K. Characteristics that modify the effect of small-quantity lipid-based nutrient supplementation on child anemia and micronutrient status: an individual participant data meta-analysis of randomized controlled trials. American Journal Of Clinical Nutrition 2021, 114: 68-94. PMID: 34590114, PMCID: PMC8560313, DOI: 10.1093/ajcn/nqab276.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsPrevalence of anemiaIndividual participant dataIron deficiencyRetinol-binding proteinEffect modifiersChild anemiaSmall-quantity lipid-based nutrient supplementationStatus outcomesIndividual-level effect modifiersLipid-based nutrient supplementationLipid-based nutrient supplementsParticipant dataIndividual-level modifiersIron deficiency anemiaFe/dMo of ageFixed-effects modelDeficiency anemiaChild's hemoglobinEffect modificationIron statusChildren 6Study design characteristicsPlasma zinc
2017
Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial
Abbeddou S, Yakes Jimenez E, Somé J, Ouédraogo J, Brown. K, Hess S. Small-quantity lipid-based nutrient supplements containing different amounts of zinc along with diarrhea and malaria treatment increase iron and vitamin A status and reduce anemia prevalence, but do not affect zinc status in young Burkinabe children: a cluster-randomized trial. BMC Pediatrics 2017, 17: 46. PMID: 28152989, PMCID: PMC5288861, DOI: 10.1186/s12887-016-0765-9.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsNon-intervention cohortLipid-based nutrient supplementsRetinol-binding proteinIntervention cohortAnemia prevalenceIllness treatmentIC childrenYoung Burkinabe childrenLower retinol-binding proteinSoluble transferrin receptorLower anemia prevalenceIron deficiency prevalenceCluster-randomized trialIndicators of ironPackage of interventionsIndicator of vitaminMonths of ageDifferent treatment groupsGroup-wise differencesTwo-stage clusterNIC childrenNutrient supplementsResultsAt baselineBurkinabe children
2015
Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial
Somé J, Abbeddou S, Jimenez E, Hess S, Ouédraogo Z, Guissou R, Vosti S, Ouédraogo J, Brown K. Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial. BMJ Open 2015, 5: e007828. PMID: 26362661, PMCID: PMC4567679, DOI: 10.1136/bmjopen-2015-007828.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsAcute lower respiratory tract infectionSmall-quantity lipid-based nutrient supplementsIncidence of diarrheaLower respiratory tract infectionsUpper respiratory tract infectionLipid-based nutrient supplementsSQ-LNSCluster-randomised trialPlacebo tabletsLongitudinal prevalenceIntervention groupPreventive zinc supplementationFrequency of diarrheaMonths of ageYoung childrenRural Burkina FasoMorbidity surveillanceNutrient supplementsTract infectionsRespiratory infectionsUncomplicated diarrheaZinc supplementationDiarrheaFever
2014
Asymptomatic Malaria Infection Affects the Interpretation of Biomarkers of Iron and Vitamin A Status, Even after Adjusting for Systemic Inflammation, but Does Not Affect Plasma Zinc Concentrations among Young Children in Burkina Faso
Wessells K, Hess S, Ouédraogo Z, Rouamba N, Ouédraogo J, Brown K. Asymptomatic Malaria Infection Affects the Interpretation of Biomarkers of Iron and Vitamin A Status, Even after Adjusting for Systemic Inflammation, but Does Not Affect Plasma Zinc Concentrations among Young Children in Burkina Faso. Journal Of Nutrition 2014, 144: 2050-2058. PMID: 25411038, DOI: 10.3945/jn.114.200345.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAcute-Phase ReactionAdolescentAnemia, Iron-DeficiencyAsymptomatic DiseasesBiomarkersBurkina FasoC-Reactive ProteinChildCross-Sectional StudiesDietary SupplementsFemaleFerritinsHemoglobinsHumansIron, DietaryLinear ModelsMalariaMaleMicronutrientsNutritional StatusOrosomucoidPrevalenceProteinsRandomized Controlled Trials as TopicRetinol-Binding ProteinsVitamin AVitamin A DeficiencyZincConceptsAcute phase proteinsElevated acute phase proteinsAsymptomatic malaria infectionsMalaria infectionMicronutrient statusBiomarkers of ironSoluble transferrin receptorVitamin A StatusAcute phase responseIndicators of ironPlasma zinc concentrationAsymptomatic malariaAsymptomatic childrenSystemic inflammationMalaria parasitemiaHigh prevalenceA StatusPhase proteinsInterpretation of biomarkersZinc statusIron deficiencyLower RBPHRP2PrevalenceMicronutrient deficiencies
2010
Acceptability of zinc‐fortified, lipid‐based nutrient supplements (LNS) prepared for young children in Burkina Faso
Hess S, Bado L, Aaron G, Ouédraogo J, Zeilani M, Brown K. Acceptability of zinc‐fortified, lipid‐based nutrient supplements (LNS) prepared for young children in Burkina Faso. Maternal And Child Nutrition 2010, 7: 357-367. PMID: 21159124, PMCID: PMC6860760, DOI: 10.1111/j.1740-8709.2010.00287.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBurkina FasoConsumer BehaviorDietary FatsDietary SupplementsDose-Response Relationship, DrugFemaleFocus GroupsHumansInfantInfant FoodInfant Nutritional Physiological PhenomenaInterviews as TopicMaleMicronutrientsNutritive ValueSocioeconomic FactorsSurveys and QuestionnairesYoung AdultZincConceptsLipid-based nutrient supplementsAcceptability studyYoung childrenPublic health concernPossible adverse effectsNutrient supplementsNutritional statusComplementary foodsChildren 9Health concernLow-income countriesMaternal reportsAdverse effectsTrialsChildren's consumptionMicronutrient deficienciesMothersChildrenGood acceptabilityDoseDetectable differenceTime of consumptionSupplementsNovel strategyDetection of differences