HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda
Kyabayinze D, Zongo I, Cunningham J, Gatton M, Angutoko P, Ategeka J, Compaoré Y, Muehlenbachs A, Mulondo J, Nakalembe M, Somé F, Ouattara A, Rouamba N, Ouédraogo J, Hopkins H, Bell D. HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda. PLOS ONE 2016, 11: e0156954. PMID: 27380525, PMCID: PMC4933335, DOI: 10.1371/journal.pone.0156954.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, ProtozoanBurkina FasoDiagnostic Tests, RoutineFemaleFollow-Up StudiesHost-Parasite InteractionsHumansInfant, NewbornL-Lactate DehydrogenaseMalaria, FalciparumMicroscopyPlasmodium falciparumPoint-of-Care SystemsPolymerase Chain ReactionPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdPrenatal CareProspective StudiesProtozoan ProteinsReproducibility of ResultsSeasonsSensitivity and SpecificityUgandaYoung AdultConceptsPLDH rapid diagnostic testsRapid diagnostic testsHistidine-rich protein 2Screening testMulti-center prospective studyDiagnostic testsDifferent malaria transmission settingsTororo District HospitalIntermittent preventive treatmentProspective cohort studyLow-density infectionsPCR-positive womenMalaria transmission settingsAppropriate screening testsTest positivity rateTreatment of malariaAntenatal visitsCohort studySymptomatic womenExpert microscopyThird trimesterIntermittent screeningPregnant womenProspective studyMalaria infection