Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis
Hoglund RM, Workman L, Edstein MD, Thanh NX, Quang NN, Zongo I, Ouedraogo JB, Borrmann S, Mwai L, Nsanzabana C, Price RN, Dahal P, Sambol NC, Parikh S, Nosten F, Ashley EA, Phyo AP, Lwin KM, McGready R, Day NP, Guerin PJ, White NJ, Barnes KI, Tarning J. Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis. PLOS Medicine 2017, 14: e1002212. PMID: 28072872, PMCID: PMC5224788, DOI: 10.1371/journal.pmed.1002212.Peer-Reviewed Original ResearchConceptsPiperaquine exposureDose regimenFalciparum malariaSmall childrenLarger childrenDay 7 plasma concentrationsThree-compartment disposition modelUncomplicated Plasmodium falciparum malariaNonlinear mixed-effects modellingPopulation pharmacokinetic propertiesIndividual Participant Data Meta-AnalysisPlasmodium falciparum malariaPopulation pharmacokinetic modelData Meta-AnalysisGuideline development groupUseful therapeutic lifeYoung childrenWorldWide Antimalarial Resistance NetworkConcentration-time dataWorld Health OrganizationDose occasionPiperaquine pharmacokineticsMixed-effects modellingUncomplicated malariaDose regimens