2001
Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City.
Comer J, Diaz T, Vlahov D, Monterroso E, Childs J. Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City. American Journal Of Tropical Medicine And Hygiene 2001, 65: 855-60. PMID: 11791987, DOI: 10.4269/ajtmh.2001.65.855.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, BacterialBartonellaBartonella InfectionsCohort StudiesCross ReactionsFemaleFluorescent Antibody Technique, IndirectHIV SeropositivityHumansMaleNew York CityPrevalenceRatsRickettsiaRickettsia InfectionsSubstance Abuse, IntravenousSurveys and QuestionnairesUrban HealthConceptsInjection drug usersDrug usersGroup rickettsiaeSerum samplesIntravenous drug usersCross-adsorption studiesEast HarlemR. akari infectionPrimary etiologic agentTyphus group rickettsiaeFever group rickettsiaeIDU populationHigh prevalenceEtiologic agentNew York CityRickettsia akariBartonella henselaeAntigenTesting panelsRickettsia typhiB. henselaeBartonella quintanaR. rickettsiiRickettsia infectionR. akariPersistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato.
Castro M, Nicholson W, Kramer V, Childs J. Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato. American Journal Of Tropical Medicine And Hygiene 2001, 65: 261-7. PMID: 11693866, DOI: 10.4269/ajtmh.2001.65.261.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialArachnid VectorsBase SequenceBorrelia burgdorferiCaliforniaDisease ReservoirsDNA, BacterialEhrlichiaEhrlichiosisFemaleFluorescent Antibody Technique, IndirectHeat-Shock ProteinsHumansIxodesMaleMicePolymerase Chain ReactionRatsRodent DiseasesSeasonsSeroepidemiologic StudiesSigmodontinaeZoonosesConceptsPolymerase chain reaction testingGroESL heat shock operonPersistent infectionReaction testingRatsE. phagocytophilaLyme diseaseBorrelia burgdorferiMiceSeropositive animalsDusky-footed wood ratsPCRWood ratsSeroreversionSensu latoSeroconversionSeropositiveBiopsySerologySeroreactivityInfectionDiseaseBloodAdult Ixodes pacificus CooleySerumClinical and Serological Follow-Up of Patients with Human Granulocytic Ehrlichiosis in Slovenia
Lotrič-Furlan S, Avsic-Zupanc T, Petrovec M, Nicholson W, Sumner J, Childs J, Strle F. Clinical and Serological Follow-Up of Patients with Human Granulocytic Ehrlichiosis in Slovenia. MSphere 2001, 8: 899-903. PMID: 11527800, PMCID: PMC96168, DOI: 10.1128/cdli.8.5.899-903.2001.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAntibody titersTick biteLong-term clinical consequencesGranulocytic ehrlichiosisIFA antibody titersOnset of feverSerological Follow-UpHigh antibody titersMost time pointsSeronegative patientsSeropositive patientsAdult patientsFebrile illnessPatients 6Initial presentationClinical outcomesAntibody responseClinical evaluationFollow-upReciprocal titersClinical consequencesSerum collectionFirst presentationPatientsSerologic evidence of Rickettsia akari infection among dogs in a metropolitan city.
Comer J, Vargas M, Poshni I, Childs J. Serologic evidence of Rickettsia akari infection among dogs in a metropolitan city. Journal Of The American Veterinary Medical Association 2001, 218: 1780-2. PMID: 11394829, DOI: 10.2460/javma.2001.218.1780.Peer-Reviewed Original ResearchConceptsIndirect immunofluorescence antibodyEnzyme immunoassaySerum samplesPossible risk factorsFever group rickettsiaeClinical illnessRoutine careSerologic evidenceSeropositive dogsRisk factorsTime serum samplesIFA testingClinical relevanceImmunofluorescence antibodySerologic surveyRickettsia akariInfectionGroup rickettsiaeDogsTitersCausative agentVeterinary clinicsFurther studiesDog ownersTick infestationFort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus
McCall C, Curns A, Rotz L, Singleton J, Treadwell T, Comer J, Nicholson W, Olson J, Childs J. Fort Chaffee Revisited: The Epidemiology of Tick-Borne Rickettsial and Ehrlichial Diseases at a Natural Focus. Vector-Borne And Zoonotic Diseases 2001, 1: 119-127. PMID: 12653142, DOI: 10.1089/153036601316977723.Peer-Reviewed Original ResearchConceptsTick-borne pathogensSerum samplesRetrospective cohort studyDetectable antibody titersPrimary risk factorRisk of transmissionFort ChaffeeFever group rickettsiaeCompatible illnessReactive EIAsTick-borne diseaseCohort studyDoxycycline useAntibody titersRisk factorsTick biteEhrlichial diseasesGroup rickettsiaeDiseaseMore pathogensProbable diseaseSeropositivityIllnessEhrlichia speciesInfection
2000
DETECTION OF ANTIBODIES REACTIVE WITH EHRLICHIA CHAFFEENSIS IN THE RACCOON
Comer J, Nicholson W, Paddock C, Sumner J, Childs J. DETECTION OF ANTIBODIES REACTIVE WITH EHRLICHIA CHAFFEENSIS IN THE RACCOON. Journal Of Wildlife Diseases 2000, 36: 705-712. PMID: 11085432, DOI: 10.7589/0090-3558-36.4.705.Peer-Reviewed Original Research
1999
Outcome of Diagnostic Tests Using Samples from Patients with Culture-Proven Human Monocytic Ehrlichiosis: Implications for Surveillance
Childs J, Sumner J, Nicholson W, Massung R, Standaert S, Paddock C. Outcome of Diagnostic Tests Using Samples from Patients with Culture-Proven Human Monocytic Ehrlichiosis: Implications for Surveillance. Journal Of Clinical Microbiology 1999, 37: 2997-3000. PMID: 10449489, PMCID: PMC85432, DOI: 10.1128/jcm.37.9.2997-3000.1999.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialEhrlichia chaffeensisEhrlichiosisFluorescent Antibody Technique, IndirectHumansImmunoglobulin GImmunoglobulin MPolymerase Chain ReactionConceptsHuman monocytic ehrlichiosisDiagnosis of HMEConvalescent-phase serum samplesMonocytic ehrlichiosisDetection of morulaeInitial clinical presentationCulture-proven casesE. chaffeensis antigenWhole blood specimensCompatible illnessClinical presentationInitial presentationSerologic responseCase definitionHME patientsBlood specimensImmunoglobulin MPatientsBlood smearsIndirect immunofluorescenceEhrlichial DNADiagnostic testsSerum samplesProbable diseaseEhrlichia chaffeensisSerologic evidence of rickettsialpox (Rickettsia akari) infection among intravenous drug users in inner-city Baltimore, Maryland.
Comer J, Tzianabos T, Flynn C, Vlahov D, Childs J. Serologic evidence of rickettsialpox (Rickettsia akari) infection among intravenous drug users in inner-city Baltimore, Maryland. American Journal Of Tropical Medicine And Hygiene 1999, 60: 894-8. PMID: 10403316, DOI: 10.4269/ajtmh.1999.60.894.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialBaltimoreCohort StudiesCross ReactionsDrinkingFemaleFluorescent Antibody Technique, IndirectHIV SeropositivityHumansIll-Housed PersonsMaleRickettsiaRickettsia InfectionsRickettsia rickettsiiRisk FactorsSeroepidemiologic StudiesSubstance Abuse, IntravenousUrban PopulationConceptsIntravenous drug usersInner-city BaltimoreDrug usersSerologic evidenceSerum samplesAcute febrile illnessR. rickettsiiR. akariHuman immunodeficiency virusSignificant risk factorsSignificant inverse associationCross-adsorption studiesPresence of antibodiesSingle serum sampleR. akari infectionFrequency of injectionsFever group rickettsiaeFebrile illnessUndetermined etiologyImmunodeficiency virusInverse associationRisk factorsGroup-specific antibodiesDrug useHigh titersEXPERIMENTAL INFECTION OF COTTON RATS WITH THREE NATURALLY OCCURRING BARTONELLA SPECIES
Kosoy M, Regnery R, Kosaya O, Childs J. EXPERIMENTAL INFECTION OF COTTON RATS WITH THREE NATURALLY OCCURRING BARTONELLA SPECIES. Journal Of Wildlife Diseases 1999, 35: 275-284. PMID: 10231754, DOI: 10.7589/0090-3558-35.2.275.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialBacteremiaBartonellaBartonella InfectionsDisease Models, AnimalFemaleMaleRodent DiseasesSigmodontinaeConceptsCotton ratsHigh dosesLow dosesBartonella sppHigh IgG titersHumoral immune responseHigh antibody titersGroups of ratsKinetics of infectionChallenge antigenIgG titersAntibody titersDetectable bacteremiaSecondary challengeImmune responseLow doseHigh doseHigher bacteremiaBacteremiaExperimental infectionSame rodent speciesRatsEvidence of resistanceInactivated bacteriaPeak bacteremiaFamily Cluster of Rocky Mountain Spotted Fever
Jones T, Craig A, Paddock C, McKechnie D, Childs J, Zaki S, Schaffner W. Family Cluster of Rocky Mountain Spotted Fever. Clinical Infectious Diseases 1999, 28: 853-859. PMID: 10825050, DOI: 10.1086/515213.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BacterialCluster AnalysisFamily HealthFemaleHumansInfantMaleMiddle AgedRickettsia rickettsiiRocky Mountain Spotted FeverLongitudinal study of infection with Borrelia burgdorferi in a population of Peromyscus leucopus at a Lyme disease-enzootic site in Maryland.
Hofmeister E, Ellis B, Glass G, Childs J. Longitudinal study of infection with Borrelia burgdorferi in a population of Peromyscus leucopus at a Lyme disease-enzootic site in Maryland. American Journal Of Tropical Medicine And Hygiene 1999, 60: 598-609. PMID: 10348235, DOI: 10.4269/ajtmh.1999.60.598.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionB. burgdorferiJuvenile miceCross-sectional sampleEar tissueBorrelia burgdorferi infectionIxodes scapularis ticksInfected miceSusceptible miceChronic infectionOverall prevalenceIncidence rateBurgdorferi infectionHigh riskLower riskInfectionMiceInfected ticksLongitudinal sampleBorrelia burgdorferiScapularis ticksChain reactionBurgdorferiLongitudinal studyIndirect transmissionSerologic Testing for Human Granulocytic Ehrlichiosis at a National Referral Center
Comer J, Nicholson W, Olson J, Childs J. Serologic Testing for Human Granulocytic Ehrlichiosis at a National Referral Center. Journal Of Clinical Microbiology 1999, 37: 558-564. PMID: 9986812, PMCID: PMC84468, DOI: 10.1128/jcm.37.3.558-564.1999.Peer-Reviewed Original ResearchConceptsHGE agentSerum samplesNational referral centerE. chaffeensis antigenSpecific etiologic agentState health departmentsE. chaffeensisHuman granulocytic ehrlichiosis (HGE) agentHuman granulocytic ehrlichiosisHuman monocytic ehrlichiosisReferral centerSerologic testingEhrlichial antigenAverage ageHealth departmentsHuman ehrlichiosisPatientsEtiologic agentProbable casesHigh titersIll individualsGranulocytic ehrlichiosisDisease controlIndirect immunofluorescenceMonocytic ehrlichiosis
1998
ISOLATION OF BARTONELLA SPP. FROM EMBRYOS AND NEONATES OF NATURALLY INFECTED RODENTS
Kosoy M, Regnery R, Kosaya O, Jones D, Marston E, Childs J. ISOLATION OF BARTONELLA SPP. FROM EMBRYOS AND NEONATES OF NATURALLY INFECTED RODENTS. Journal Of Wildlife Diseases 1998, 34: 305-309. PMID: 9577777, DOI: 10.7589/0090-3558-34.2.305.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntibodies, BacterialBacteremiaBartonellaBartonella InfectionsCitrate (si)-SynthaseColony Count, MicrobialEmbryo, MammalianFemaleFetal DiseasesInfectious Disease Transmission, VerticalPeromyscusPhylogenyPlacentaPregnancyPregnancy Complications, InfectiousRodent DiseasesSigmodontinaeSerologic Evidence of Infection with Ehrlichia spp. in Wild Rodents (Muridae: Sigmodontinae) in the United States
Nicholson W, Muir S, Sumner J, Childs J. Serologic Evidence of Infection with Ehrlichia spp. in Wild Rodents (Muridae: Sigmodontinae) in the United States. Journal Of Clinical Microbiology 1998, 36: 695-700. PMID: 9508298, PMCID: PMC104611, DOI: 10.1128/jcm.36.3.695-700.1998.Peer-Reviewed Original ResearchRetrospective Serosurvey for Human Granulocytic Ehrlichiosis Agent in Urban White-footed Mice from Maryland
Bunnell J, Stephen D, Childs J, Glass G. Retrospective Serosurvey for Human Granulocytic Ehrlichiosis Agent in Urban White-footed Mice from Maryland. Journal Of Wildlife Diseases 1998, 34: 179-181. PMID: 9476244, DOI: 10.7589/0090-3558-34.1.179.Peer-Reviewed Original Research
1997
Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States.
Kosoy M, Regnery R, Tzianabos T, Marston E, Jones D, Green D, Maupin G, Olson J, Childs J. Distribution, diversity, and host specificity of Bartonella in rodents from the Southeastern United States. American Journal Of Tropical Medicine And Hygiene 1997, 57: 578-88. PMID: 9392599, DOI: 10.4269/ajtmh.1997.57.578.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialBacteremiaBartonellaGenotypeMicePhylogenyRatsRodentiaUnited StatesConceptsPhylogenetic groupsHost specificityDistinct phylogenetic groupsCitrate synthase geneSpecies of PeromyscusMajor biotic communitiesSpecies of rodentsSoutheastern United StatesDegree of homologyRodent communitiesSynthase geneWild-caught rodentsBiotic communitiesSequence homologyBartonella isolatesSequence analysisBartonellaSpeciesHomologyGenotypic groupsGenotypic variantsGeographic sitesSingle siteRodentsGenesAn indirect immunofluorescence assay using a cell culture-derived antigen for detection of antibodies to the agent of human granulocytic ehrlichiosis
Nicholson W, Comer J, Sumner J, Gingrich-Baker C, Coughlin R, Magnarelli L, Olson J, Childs J. An indirect immunofluorescence assay using a cell culture-derived antigen for detection of antibodies to the agent of human granulocytic ehrlichiosis. Journal Of Clinical Microbiology 1997, 35: 1510-1516. PMID: 9163471, PMCID: PMC229776, DOI: 10.1128/jcm.35.6.1510-1516.1997.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisCell culture-derived antigenHuman antibodiesGranulocytic ehrlichiosisIndirect immunofluorescenceHGE agentAnimal-derived antigensDetection of antibodiesTick-derived isolatesPromyelocytic leukemia cell lineAntigen presentationHuman promyelocytic leukemia cell lineHealthy individualsLeukemia cell linesHGE patientsSera reactiveEhrlichia phagocytophilaHigh titersAntigenImmunofluorescence methodE. equiEhrlichia equiRoutine testingAntibodiesSpecific antibodiesSurvey of veterinary professionals and other veterinary conference attendees for antibodies to Bartonella henselae and B quintana.
Noah D, Kramer C, Verbsky M, Rooney J, Smith K, Childs J. Survey of veterinary professionals and other veterinary conference attendees for antibodies to Bartonella henselae and B quintana. Journal Of The American Veterinary Medical Association 1997, 210: 342-4. PMID: 9057914, DOI: 10.2460/javma.1997.210.03.342.Peer-Reviewed Original ResearchConceptsCat-scratch diseaseB quintanaBartonella henselaeOccupational groupsVeterinary techniciansIllness consistentPrevious diagnosisEpidemiologic characteristicsPotential confoundersOverall seroprevalenceUnknown prevalenceB henselaeEpidemiologic SurveyHospital staffCat ownershipSp infectionExposure informationSerum samplesVeterinary conferencesHenselaeSeropositivitySpecies of BartonellaSeroprevalenceInfectionUnknown duration
1996
Antibodies to Bartonella Species in Inner-city Intravenous Drug Users in Baltimore, Md
Comer J, Flynn C, Regnery R, Vlahov D, Childs J. Antibodies to Bartonella Species in Inner-city Intravenous Drug Users in Baltimore, Md. JAMA Internal Medicine 1996, 156: 2491-2495. PMID: 8944742, DOI: 10.1001/archinte.1996.00440200111014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, BacterialBaltimoreBartonellaFemaleHIV SeropositivityHumansLogistic ModelsMaleRisk FactorsSubstance Abuse, IntravenousUrban HealthConceptsIntravenous drug usersHuman immunodeficiency virus statusB quintanaRisk factorsDrug usersB henselaeDrug useVirus statusHuman immunodeficiency virus-seropositive individualsHuman immunodeficiency virus (HIV) infectionSerum samplesImmunodeficiency virus infectionAvailable serum samplesSignificant risk factorsBehavioral risk factorsPossible risk factorsSignificant inverse associationIndirect immunofluorescent antibodyFrequency of injectionsUrban transmission cyclesBartonella speciesBartonella organismsMode of transmissionCurrent natural historyImmunodeficiency syndrome
1995
Cluster of five children with acute encephalopathy associated with cat-scratch disease in South Florida
NOAH D, BRESEE J, GORENSEK M, ROONEY J, CRESANTA J, REGNERY R, WONG J, DEL TORO J, OLSON J, CHILDS J. Cluster of five children with acute encephalopathy associated with cat-scratch disease in South Florida. The Pediatric Infectious Disease Journal 1995, 14: 866-869. PMID: 8584313, DOI: 10.1097/00006454-199510000-00009.Peer-Reviewed Original ResearchConceptsCat-scratch diseaseAcute encephalopathyEvaluation of childrenIndirect fluorescent antibodyRegional lymphadenopathyStatus epilepticusSingle hospitalEncephalopathy casesBartonella henselaeEncephalopathyB. henselaeFocal clustersCausative agentFluorescent antibodyStray catsDiseaseChildrenAntibodiesHenselaeHigher proportionCatsLymphadenopathyEpilepticusEncephalitisPatients