Isolation of the causative agent of hantavirus pulmonary syndrome.
Elliott L, Ksiazek T, Rollin P, Spiropoulou C, Morzunov S, Monroe M, Goldsmith C, Humphrey C, Zaki S, Krebs J, Maupin G, Gage K, Childs J, Nichol S, Peters C. Isolation of the causative agent of hantavirus pulmonary syndrome. American Journal Of Tropical Medicine And Hygiene 1994, 51: 102-8. PMID: 8059907, DOI: 10.4269/ajtmh.1994.51.102.Peer-Reviewed Original ResearchConceptsHantavirus pulmonary syndromePulmonary syndromeAcute respiratory illnessReverse transcriptase-polymerase chain reactionCausative agentTypical morphologic featuresConvalescent-phase seraTranscriptase-polymerase chain reactionUnknown hantavirusRespiratory illnessLung tissueHPS patientsVirus antigenEtiologic agentHigh mortalityMorphologic featuresIndirect immunofluorescenceGenus HantavirusVero cellsInfected cellsChain reactionRecent outbreakCell linesSyndromeDeer miceDes souris et des hommes, chronique d'une épidémie non annoncée
Rollin P, Ksiazek T, Nichol S, Zaki S, Childs J, Spiropoulou C, Morzunov S, Feldmann H, Sanchez A, Krebs J, Khan A, Martin M, Oronoz-Perez G, Peters C. Des souris et des hommes, chronique d'une épidémie non annoncée. Infectious Diseases Now 1994, 24: 517-520. DOI: 10.1016/s0399-077x(05)81258-2.Peer-Reviewed Original ResearchAdult respiratory distress syndromeAcute pulmonary edemaAcute respiratory distressRespiratory distress syndromeCompatible clinical historyActive immune responseLocal health departmentsHealthy young adultsNational Reference CenterNational surveillance programFebrile prodromeDistress syndromeRespiratory distressEpidemiologic featuresPulmonary edemaPathogenetic linkClinical historyControl subjectsLung tissueSerologic testsVirus antigenHantavirus antigensImmune responseHealthy personsRapid onset