1999
Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease
Paddock C, Greer P, Ferebee T, Singleton J, McKechnie D, Treadwell T, Krebs J, Clarke M, Holman R, Olson J, Childs J, Zaki S. Hidden Mortality Attributable to Rocky Mountain Spotted Fever: Immunohistochemical Detection of Fatal, Serologically Unconfirmed Disease. The Journal Of Infectious Diseases 1999, 179: 1469-1476. PMID: 10228069, DOI: 10.1086/314776.Peer-Reviewed Original ResearchConceptsCase fatality ratioDiagnosis of RMSFIHC stainingRocky Mountain Spotted FeverLaboratory-confirmed casesAcute-phase seraTickborne infectionHidden mortalityIgM antibodiesDiagnostic titerPolymerase chain reactionIHC findingsPatient seraSerologic assaysImmunohistochemical stainingSpotted FeverImmunohistochemical detectionFatal diseasePatientsDisease controlIndirect immunofluorescenceNotifiable diseaseDiseaseUnderestimates of mortalityTissue samples
1994
Emergence of hantavirus disease in the USA and Europe
Childs J, Rollin P. Emergence of hantavirus disease in the USA and Europe. Current Opinion In Infectious Diseases 1994, 7: 220-224. DOI: 10.1097/00001432-199404000-00014.Peer-Reviewed Original ResearchWorldwide public health problemAcute pulmonary diseaseAcute renal failureHigh case fatality ratioCase fatality ratioPublic health problemRenal failurePulmonary diseaseHantavirus diseaseFatality ratioExplosive outbreaksImportant causeHealth problemsDiseaseZoonotic agentsHantavirusesFirst isolationOutbreakEnvironmental factorsImportant role