2024
A mediation analysis framework based on variance component to remove genetic confounding effect
Dong Z, Zhao H, DeWan A. A mediation analysis framework based on variance component to remove genetic confounding effect. Journal Of Human Genetics 2024, 69: 301-309. PMID: 38528049, DOI: 10.1038/s10038-024-01232-x.Peer-Reviewed Original ResearchMediation analysis frameworkSingle nucleotide polymorphismsMediation analysisPleiotropic single nucleotide polymorphismsUK Biobank dataConfounding effectsTrait pairsBiobank dataIndividual-levelEpidemiological studiesCausal effectsGenetic signalsEstimated effectsLinear regressionNucleotide polymorphismsStandard errorData analysisGenetic correlationsPhenotypeIndirect effectsPleiotropyVariance componentsOutcomesRegression
2015
Introduction to statistical methods in genome-wide association studies
Yang C, Li C, Chung D, Chen M, Gelernter J, Zhao H. Introduction to statistical methods in genome-wide association studies. 2015, 26-52. DOI: 10.1017/cbo9781107337459.005.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesPopulation genomic studiesQuantitative trait lociComplex diseasesTrait lociGenomic studiesSingle nucleotide polymorphismsGenetic basisNumber variantsNucleotide polymorphismsPharmaceutical potentialUnique resourceGenomicsLociBroad impactHaplotypesStatistical methodsPolymorphismVariantsPharmacogenomicseQTL mapping
Chen M, Yang C, Li C, Zhao H. eQTL mapping. 2015, 208-228. DOI: 10.1017/cbo9781107337459.016.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesPopulation genomic studiesQuantitative trait lociComplex diseasesEQTL mappingTrait lociGenomic studiesSingle nucleotide polymorphismsGenetic basisNumber variantsNucleotide polymorphismsPharmaceutical potentialUnique resourceGenomicsLociBroad impactHaplotypesPolymorphism