1997
Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess
Melegos D, Yu H, Ashok M, Wang C, Stanczyk F, Diamandis E. Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 777-780. PMID: 9062481, DOI: 10.1210/jcem.82.3.3792.Peer-Reviewed Original ResearchConceptsProstate-specific antigenMarker of androgen excessSerum prostate-specific antigenHirsute womenReceiver operating characteristicAndrogen actionAndrogen excessLevels of prostate-specific antigenProstate-specific antigen levelProstate-specific antigen geneFemale serumAction of steroid hormone receptorsMarker of androgen actionAlpha-androstanediol glucuronideSerum PSA levelsFerriman-Gallwey scorePotential new markerSteroid hormone receptorsPSA levelsProstate-specificHyperandrogenic statePatient ageAlpha-androstanediolAlpha-AgBiochemical markers
1996
Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer
Yu H, Levesque M, Khosravi M, Papanastasiou-Diamandi A, Clark G, Diamandis E. Associations between insulin-like growth factors and their binding proteins and other prognostic indicators in breast cancer. British Journal Of Cancer 1996, 74: 1242-1247. PMID: 8883411, PMCID: PMC2075943, DOI: 10.1038/bjc.1996.523.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorProstate-specific antigenIGFBP-3IGF-IIBreast cancerS-phase fractionIGFBP-1Prognostic indicatorGrowth factorActive insulin-like growth factorsHER-2/neu proteinUnfavourable prognostic indicatorPrimary breast cancerEpidermal growth factor receptorSteroid hormone receptorsTumor tissue cytosolGrowth factor receptorIGF functionEstrogen receptorDNA ploidyPossible associationNeu proteinCancerTissue cytosolsHormone receptors
1995
Quantification of creatine kinase BB isoenzyme in tumor cytosols and serum with an ultrasensitive time-resolved immunofluorometric technique
Zarghami N, Yu H, Diamandis E, Sutherland D. Quantification of creatine kinase BB isoenzyme in tumor cytosols and serum with an ultrasensitive time-resolved immunofluorometric technique. Clinical Biochemistry 1995, 28: 243-253. PMID: 7554242, DOI: 10.1016/0009-9120(95)00010-7.Peer-Reviewed Original ResearchConceptsCK-BB levelsBreast tumor cytosolsCreatine kinase BBCK-BBProstate cancerTumor cytosolsCancer patientsEstrogen sensitivityHealthy subjectsSerum CK-BB levelsActive prostate cancerSensitive immunofluorometric procedurePost-radical prostatectomyProstate cancer patientsSerum CK-BBCK-BB isoenzymeSteroid hormone receptorsSerum PSAProgesterone receptorRadical prostatectomyBreast cancerMale volunteersHealthy volunteersPatientsBreast tumors
1994
Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age
Yu H, Diamandis E, Sutherland D. Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age. Clinical Biochemistry 1994, 27: 75-79. PMID: 7520846, DOI: 10.1016/0009-9120(94)90015-9.Peer-Reviewed Original ResearchConceptsProstate-specific antigenIR-PSAMale breast tumorsBreast tumor cytosolsBreast tumorsPatient agePositivity rateTumor cytosolsImmunoreactive prostate-specific antigenProstate-specific antigen levelPR-positive tumorsBreast cancer patientsSubset of tumorsCancerous prostatic tissueSteroid hormone receptorsAntigen levelsCancer patientsProgesterone receptorBreast cancerProstatic tissuePR actionEstrogenTumorsHormone receptorsSpecific markersQuantitative analysis of mutant p53 protein in breast tumor cytosols and study of its association with other biochemical prognostic indicators in breast cancer
Levesque M, Diamandis E, Yu H, Sutherland D. Quantitative analysis of mutant p53 protein in breast tumor cytosols and study of its association with other biochemical prognostic indicators in breast cancer. Breast Cancer Research And Treatment 1994, 30: 179-195. PMID: 7524772, DOI: 10.1007/bf00666062.Peer-Reviewed Original ResearchConceptsCarcinoembryonic antigenPrognostic indicatorBreast cancerBreast tumorsBiochemical prognostic indicatorsCandidate prognostic indicatorBreast tumor cytosolsSteroid hormone receptorsNegative associationProgesterone receptorTumor cytosolsMutant p53 proteinTumor extractsP53 tumor suppressor gene productSpecific antigenBiochemical parametersObserved associationsHormone receptorsImmunofluorometric procedureStrong positive associationCognate steroid ligandP53 proteinReceptorsStrong negative associationTumor suppressor gene product