A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer
Gunter M, Hoover D, Yu H, Wassertheil-Smoller S, Manson J, Li J, Harris T, Rohan T, Xue X, Ho G, Einstein M, Kaplan R, Burk R, Wylie-Rosett J, Pollak M, Anderson G, Howard B, Strickler H. A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 921-929. PMID: 18398032, PMCID: PMC3090086, DOI: 10.1158/1055-9965.epi-07-2686.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Mass IndexCarcinoma, EndometrioidEndometrial NeoplasmsEstradiolFemaleHumansHypoglycemic AgentsInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Middle AgedMulticenter Studies as TopicObesityProportional Hazards ModelsProspective StudiesRisk FactorsConceptsInsulin-like growth factorEndometrial cancerEndometrioid adenocarcinomaRisk factorsFree IGFObese womenEstrogen levelsWomen's Health Initiative Observational StudyFree IGF-I levelsIGF-binding protein-3Growth factorBaseline serum specimensIncident endometrial cancerHormone therapy useIGF-I levelsMain histologic typesCase-cohort studyMajor risk factorHigh estrogen levelsTotal IGFPostmenopausal womenHormone therapyProspective cohortRandom subcohortTherapy useThe insulin-like growth factor axis and risk of liver disease in hepatitis C virus/HIV-co-infected women
Strickler H, Howard A, Peters M, Fazzari M, Yu H, Augenbraun M, French A, Young M, Gange S, Anastos K, Kovacs A. The insulin-like growth factor axis and risk of liver disease in hepatitis C virus/HIV-co-infected women. AIDS 2008, 22: 527-531. PMID: 18301066, PMCID: PMC3507535, DOI: 10.1097/qad.0b013e3282f22cdf.Peer-Reviewed Original ResearchConceptsHIV-positive subjectsHIV-positive womenHepatic stellate cellsIGFBP-3Liver diseaseAPRI levelsLiver fibrosisInsulin-like growth factor binding protein 3Insulin-like growth factor (IGF) axisGrowth factor binding protein 3CD4 T-cell countWomen's Interagency HIV StudyLarge multi-institutional cohortInsulin-like growth factor IBaseline serum specimensHigher IGFBP-3T-cell countsHigh-risk patientsMulti-institutional cohortGrowth factor axisHepatitis C virusLiver function test dataGrowth factor IBinding protein 3Extracellular matrix accumulationInsulin-Like Growth Factor Axis and Oncogenic Human Papillomavirus Natural History
Harris T, Burk R, Yu H, Minkoff H, Massad L, Watts D, Zhong Y, Gange S, Kaplan R, Anastos K, Levine A, Moxley M, Xue X, Fazzari M, Palefsky J, Strickler H. Insulin-Like Growth Factor Axis and Oncogenic Human Papillomavirus Natural History. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 245-248. PMID: 18199731, DOI: 10.1158/1055-9965.epi-07-0686.Peer-Reviewed Original ResearchConceptsOncogenic human papillomavirusHuman papillomavirusNatural historyCervical neoplasiaInsulin-like growth factor (IGF) axisHuman papillomavirus (HPV) natural historyInsulin-like growth factorBaseline serum specimensDNA PCR testingOncogenic HPV infectionIGF-I levelsHigher serum levelsGrowth factor axisTotal IGFHPV infectionIGFBP-3Serum levelsCervical cancerHigher IGFIGF axisViral causeCervical cytologyCommon cancerProspective dataAbundant IGFBPInsulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Howard BV, Wylie-Rosett J, Anderson GL, Ho GY, Kaplan RC, Li J, Xue X, Harris TG, Burk RD, Strickler HD. Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women. Cancer Research 2008, 68: 329-337. PMID: 18172327, PMCID: PMC4225702, DOI: 10.1158/0008-5472.can-07-2946.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorFree IGFColorectal cancerPostmenopausal womenEndogenous estradiolWaist circumferenceWomen's Health Initiative Observational StudyIncident colorectal cancer casesGrowth factorBaseline serum specimensColorectal cancer incidenceColorectal cancer casesEndogenous estradiol levelsColorectal Cancer StudyStrong mitogenic effectIndependent biological pathwaysTotal IGFObese patientsProspective cohortRandom subcohortNondiabetic subjectsEstradiol levelsRisk factorsCancer incidenceExtreme quartiles