2000
Serum and Urinary Prostate-specific Antigen and Urinary Human Glandular Kallikrein Concentrations Are Significantly Increased after Testosterone Administration in Female-to-Male Transsexuals
Obiezu C, Giltay E, Magklara A, Scorilas A, Gooren L, Yu H, Howarth D, Diamandis E. Serum and Urinary Prostate-specific Antigen and Urinary Human Glandular Kallikrein Concentrations Are Significantly Increased after Testosterone Administration in Female-to-Male Transsexuals. Clinical Chemistry 2000, 46: 859-862. PMID: 10839777, DOI: 10.1093/clinchem/46.6.859.Peer-Reviewed Original ResearchConceptsUrinary prostate specific antigenProstate-specific antigenTestosterone administrationSerum prostate-specific antigenMale transsexualsMonths of treatmentMonths post treatmentHK2 concentrationsSerum hK2Testosterone treatmentAndrogen administrationAndrogenic stimulationKallikrein concentrationImmunofluorometric methodTime pointsHK2AdministrationMonthsWomenTreatmentPost treatmentAntigenCultured cellsFemalesCorresponding mean values
1996
Prostate specific antigen — a new constituent of breast cyst fluid
Diamandis E, Yu H, López-Otín C. Prostate specific antigen — a new constituent of breast cyst fluid. Breast Cancer Research And Treatment 1996, 38: 259-264. PMID: 8739078, DOI: 10.1007/bf01806144.Peer-Reviewed Original ResearchConceptsProstate-specific antigenBreast cyst fluidCyst fluidSpecific antigenFree prostate-specific antigenBreast cystic diseasePSA presenceWestern blot analysisCystic diseaseBreast cancerNormal breastCutoff levelΑ1-antichymotrypsinMore studiesBlot analysisHigh-performance liquid chromatographyAntigenFrequent componentPerformance liquid chromatographySerine proteasesLiquid chromatographyCancerBreastDiseaseAssay of prostate-specific antigen from whole blood spotted on filter paper and application to prostate cancer screening.
Hoffman B, Yu H, Diamandis E. Assay of prostate-specific antigen from whole blood spotted on filter paper and application to prostate cancer screening. Clinical Chemistry 1996, 42: 536-544. PMID: 8605670, DOI: 10.1093/clinchem/42.4.536.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate cancerOccult prostate cancerWhole bloodWhole blood concentrationsExtracts of bloodFilter paper procedureMicrograms/L.Cancer screeningPSA recoverySy/xBloodPlasma fractionConcentration of PSARegression analysisCancerAntigenCentralized laboratoriesMicroL of bufferMicroLFilter paperPaper discsHematocritRecoveryMonths
1995
Ultrasensitive assay of prostate-specific antigen used for early detection of prostate cancer relapse and estimation of tumor-doubling time after radical prostatectomy.
Yu H, Diamandis E, Prestigiacomo A, Stamey T. Ultrasensitive assay of prostate-specific antigen used for early detection of prostate cancer relapse and estimation of tumor-doubling time after radical prostatectomy. Clinical Chemistry 1995, 41: 430-434. PMID: 7533672, DOI: 10.1093/clinchem/41.3.430.Peer-Reviewed Original ResearchConceptsTumor-doubling timeProstate-specific antigenProstate cancer relapseRelapse-free periodRadical prostatectomyPSA assaysCancer relapseUltrasensitive prostate specific antigenProstate cancer patientsUltrasensitive assayExponential tumor growthPSA changeCancer patientsPatientsProstatectomyTumor growthEarly detectionRelapseAntigenAssaysBasis of criteriaDaysCystoprostatectomyPostsurgerySurgeryProstate-specific antigen in milk of lactating women.
Yu H, Diamandis E. Prostate-specific antigen in milk of lactating women. Clinical Chemistry 1995, 41: 54-58. PMID: 7529146, DOI: 10.1093/clinchem/41.1.54.Peer-Reviewed Original ResearchConceptsProstate-specific antigenBreast milkPSA concentrationTotal prostate-specific antigenCancerous prostatic tissueMicrograms/LConditions of stimulationWestern blot analysisWeeks postdeliveryPresence of PSANormal breastProstatic tissueAmniotic fluidMother's ageBreast tumorsFemale breastSteroid hormonesPSA-alphaSensitive prostate specific antigenGrowth factorSpecific markersPostdeliveryBlot analysisBreastAntigenImmunoreactive prostate‐specific antigen in lung tumors
Levesque M, Yu H, D'Costa M, Tadross L, Diamandis E. Immunoreactive prostate‐specific antigen in lung tumors. Journal Of Clinical Laboratory Analysis 1995, 9: 375-379. PMID: 8587005, DOI: 10.1002/jcla.1860090607.Peer-Reviewed Original ResearchConceptsProstate-specific antigenImmunoreactive prostate-specific antigenLung tumor extractsFavorable prognostic indicatorSquamous cell carcinomaSteroid hormone actionMale patientsPrognostic significanceCell carcinomaPrognostic indicatorLung cancerLung tissueBreast cancerLung tumorsPresence of PSAProstate carcinomaTumor extractsBreast tumorsBiochemical markersHormone actionTumorsEpithelial cellsCarcinomaCancerAntigen
1994
Ectopic production of prostate specific antigen by a breast tumor metastatic to the ovary
Yu H, Diamandis E, Levesque M, Sismondi P, Zola P, Katsaros D. Ectopic production of prostate specific antigen by a breast tumor metastatic to the ovary. Journal Of Clinical Laboratory Analysis 1994, 8: 251-253. PMID: 7523638, DOI: 10.1002/jcla.1860080412.Peer-Reviewed Original ResearchConceptsProstate-specific antigenMetastatic ovarian cancerPrimary breast tumorsBreast tumorsOvarian cancerSpecific antigenPrimary ovarian cancer tumorsFavorable prognostic indicatorOvarian cancer tumorsMetastatic sitesTumor metastaticPrognostic indicatorBreast cancerPSA productionEctopic productionTumorsSteroid hormonesCancer tumorsCancerPatientsAntigenTreatmentLow levelsHigh levelsMetastatic