2018
Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study
Visvanathan K, Shaw P, May BJ, Bahadirli-Talbot A, Kaushiva A, Risch H, Narod S, Wang TL, Parkash V, Vang R, Levine DA, Soslow R, Kurman R, Shih IM. Fallopian tube lesions in women at high risk for ovarian cancer: A multicenter study. Cancer Prevention Research 2018, 11: canprevres.0009.2018. PMID: 30232083, PMCID: PMC6760670, DOI: 10.1158/1940-6207.capr-18-0009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkers, TumorBRCA1 ProteinBRCA2 ProteinCystadenocarcinoma, SerousDisease ProgressionFallopian Tube NeoplasmsFallopian TubesFemaleHumansMedical History TakingMiddle AgedOvarian NeoplasmsOvaryPrecancerous ConditionsPrevalencePrognosisProspective StudiesRetrospective StudiesSalpingo-oophorectomyConceptsSerous tubal intraepithelial lesionsHigh-grade serous ovarian carcinomaSerous tubal intraepithelial carcinomaP53 signatureRisk/protective factorsProtective factorsMultiple lesionsFallopian tubePrognosis of womenHigh-risk womenTubal intraepithelial carcinomaTubal intraepithelial lesionsSerous ovarian carcinomaPutative precursor lesionsYears of ageIntraepithelial lesionsIntraepithelial carcinomaMulticenter studyInvasive cancerOvarian carcinomaDisease progressionPrecursor lesionsEpidemiologic dataCombined prevalenceTubal lesionsDisparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study
Mukhtar F, Boffetta P, Dabo B, Park JY, Tran CTD, Tran TV, Tran HT, Whitney M, Risch HA, Le LC, Zheng W, Shu XO, Luu HN. Disparities by race, age, and sex in the improvement of survival for lymphoma: Findings from a population-based study. PLOS ONE 2018, 13: e0199745. PMID: 29995909, PMCID: PMC6040734, DOI: 10.1371/journal.pone.0199745.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsFemaleHodgkin DiseaseHumansMaleMiddle AgedPopulation GroupsSex FactorsSurvival AnalysisConceptsLymphoma patientsHodgkin's lymphomaAge groupsHazard ratioDisease-specific mortalityFive-year survivalHodgkin's lymphoma patientsImprovement of survivalPopulation-based studyProportional hazards regressionConfidence intervalsCause-specific mortalityIncident lymphoma casesSEER cancer registryYears of ageOlder age groupsPatients 20Surveillance EpidemiologyCancer RegistrySurvival improvementHazards regressionLymphoma casesNHL survivalPatientsLymphoma
2017
Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013
Mukhtar F, Boffetta P, Risch HA, Park JY, Bubu OM, Womack L, Tran TV, Zgibor JC, Luu HN. Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013. International Journal Of Cancer 2017, 140: 1494-1502. PMID: 28006853, PMCID: PMC6919213, DOI: 10.1002/ijc.30576.Peer-Reviewed Original ResearchConceptsPredictors of survivalBurkitt's lymphomaSurvival predictorsMultiple primariesAge groupsCox proportional hazards regression modelFive-year relative survivalProportional hazards regression modelsStage II diseaseStage IV diseaseEnd Results (SEER) databaseAfrican American raceHazards regression modelsBL patientsElderly patientsPrognostic factorsResults databaseWorse outcomesElderly groupStage IIIAmerican raceRelative survivalHigh mortalityLymphomaDiseaseAspirin Use and Reduced Risk of Pancreatic Cancer
Risch HA, Lu L, Streicher SA, Wang J, Zhang W, Ni Q, Kidd MS, Yu H, Gao YT. Aspirin Use and Reduced Risk of Pancreatic Cancer. Cancer Epidemiology Biomarkers & Prevention 2017, 26: 68-74. PMID: 27999143, PMCID: PMC5225096, DOI: 10.1158/1055-9965.epi-16-0508.Peer-Reviewed Original ResearchConceptsPancreatic cancerAspirin useRegular useConfidence intervalsLong-term aspirin useControl subjects frequencyLow-dose aspirinAvoidance of smokingBody mass indexPopulation-based studyUnconditional logistic regressionABO blood groupRisk-benefit analysisAspirin typeCagA seropositivityDiabetes mellitusMass indexCigarette smokingCardiovascular diseaseAspirinCancerCertain cancersLogistic regressionBlood groupSubjects frequency
2016
Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus
Dai JY, de Dieu Tapsoba J, Buas MF, Consortium T, Chow W, Shaheen N, Anderson L, Corley D, Gammon M, Hardie L, Lagergren J, Whiteman D, Risch H, Vaughan T. Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus. American Journal Of Human Genetics 2016, 99: 352-365. PMID: 27486777, PMCID: PMC4974090, DOI: 10.1016/j.ajhg.2016.06.018.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAge FactorsBarrett EsophagusEsophageal NeoplasmsFemaleGastroesophageal RefluxGene-Environment InteractionGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleModels, GeneticObesityOdds RatioPolymorphism, Single NucleotideReproducibility of ResultsRisk FactorsSample SizeSex FactorsSmokingConceptsBarrett's esophagusEsophageal adenocarcinomaGene-environment interactionsMultiple risk factorsEsophageal Adenocarcinoma ConsortiumEnvironmental exposure dataGenetic variantsGastresophageal refluxTobacco smokingRisk factorsCancer epidemiologyEsophagusExposure dataAdenocarcinomaMultivariate gene-environment interactionsLow statistical powerTesting strategiesGenome-wide significanceSmokingObesityStatistical powerEpidemiologyRefluxRisk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma
McWilliams RR, Maisonneuve P, Bamlet WR, Petersen GM, Li D, Risch HA, Yu H, Fontham ET, Luckett B, Bosetti C, Negri E, La Vecchia C, Talamini R, de Mesquita H, Bracci P, Gallinger S, Neale RE, Lowenfels AB. Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma. Pancreas 2016, 45: 311-316. PMID: 26646264, PMCID: PMC4710562, DOI: 10.1097/mpa.0000000000000392.Peer-Reviewed Original ResearchConceptsEarly onset pancreatic cancerPancreatic cancerAge-dependent effectsRisk factorsFamily historySex-matched control subjectsDiagnosis of PCCase-control studyLogistic regression analysisPC patientsDiabetes mellitusAlcohol intakeControl subjectsOdds ratioPancreatic adenocarcinomaEarly onsetPatientsOlder adultsStrong associationObesitySmokingRegression analysisRiskAssociationComprehensive assessment
2015
Age‐specific risk factor profiles of adenocarcinomas of the esophagus: A pooled analysis from the international BEACON consortium
Drahos J, Xiao Q, Risch HA, Freedman ND, Abnet CC, Anderson LA, Bernstein L, Brown L, Chow W, Gammon MD, Kamangar F, Liao LM, Murray LJ, Ward MH, Ye W, Wu AH, Vaughan TL, Whiteman DC, Cook MB. Age‐specific risk factor profiles of adenocarcinomas of the esophagus: A pooled analysis from the international BEACON consortium. International Journal Of Cancer 2015, 138: 55-64. PMID: 26175109, PMCID: PMC4607633, DOI: 10.1002/ijc.29688.Peer-Reviewed Original ResearchConceptsBody mass indexNonsteroidal anti-inflammatory drugsRecurrent gastroesophageal refluxGastroesophageal refluxOlder age groupsAge groupsOdds ratioInternational BEACON ConsortiumRisk factor profileMultivariable logistic regressionEsophagogastric junction adenocarcinomaConfidence intervalsCase-control studyAge-specific associationsAge-specific riskAnti-inflammatory drugsEsophageal Adenocarcinoma ConsortiumIndividual participant dataInternational Barrett'sNSAID useJunction adenocarcinomaMass indexSmoking statusCigarette smokingEA patients
2014
Gastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
Cook MB, Corley DA, Murray LJ, Liao LM, Kamangar F, Ye W, Gammon MD, Risch HA, Casson AG, Freedman ND, Chow WH, Wu AH, Bernstein L, Nyrén O, Pandeya N, Whiteman DC, Vaughan TL. Gastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON). PLOS ONE 2014, 9: e103508. PMID: 25075959, PMCID: PMC4116205, DOI: 10.1371/journal.pone.0103508.Peer-Reviewed Original ResearchConceptsEsophagogastric junction adenocarcinomaBody mass indexRegurgitation symptomsEsophageal adenocarcinomaEsophageal Adenocarcinoma ConsortiumGastroesophageal refluxCigarette smokingMass indexMultivariable logistic regressionFrequency of symptomsMajor risk factorCase-control studyHeartburn durationSymptom durationJunction adenocarcinomaPooled analysisRisk factorsCancer sitesOdds ratioStratified analysisHigh riskSummary estimatesSignificant associationSymptomsLogistic regression
2013
Type I and II Endometrial Cancers: Have They Different Risk Factors?
Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, Wolk A, Wentzensen N, Weiss NS, Webb PM, van den Brandt PA, van de Vijver K, Thompson PJ, Group T, Strom BL, Spurdle AB, Soslow RA, Shu XO, Schairer C, Sacerdote C, Rohan TE, Robien K, Risch HA, Ricceri F, Rebbeck TR, Rastogi R, Prescott J, Polidoro S, Park Y, Olson SH, Moysich KB, Miller AB, McCullough ML, Matsuno RK, Magliocco AM, Lurie G, Lu L, Lissowska J, Liang X, Lacey JV, Kolonel LN, Henderson BE, Hankinson SE, Håkansson N, Goodman MT, Gaudet MM, Garcia-Closas M, Friedenreich CM, Freudenheim JL, Doherty J, De Vivo I, Courneya KS, Cook LS, Chen C, Cerhan JR, Cai H, Brinton LA, Bernstein L, Anderson KE, Anton-Culver H, Schouten LJ, Horn-Ross PL. Type I and II Endometrial Cancers: Have They Different Risk Factors? Journal Of Clinical Oncology 2013, 31: 2607-2618. PMID: 23733771, PMCID: PMC3699726, DOI: 10.1200/jco.2012.48.2596.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAge FactorsAgedBiopsy, NeedleCarcinoma, EndometrioidCase-Control StudiesCohort StudiesConfidence IntervalsContraceptives, OralDatabases, FactualDiabetes MellitusDisease-Free SurvivalEndometrial NeoplasmsFemaleHumansImmunohistochemistryMiddle AgedNeoplasm InvasivenessNeoplasm StagingObesityOdds RatioRisk FactorsSensitivity and SpecificitySmokingSurvival AnalysisConceptsType II tumorsII tumorsRisk factorsEndometrial cancerOdds ratioHigh-grade endometrioid tumorsEndometrial cancer risk factorsType IEndometrial Cancer ConsortiumEndometrial cancer typesType I tumorsEndometrial cancer casesOral contraceptive useRisk factor patternsBody mass indexCancer risk factorsCommon etiologic factorCase-control studyDifferent risk factorsEndometrioid tumorsI tumorsMass indexCigarette smokingPooled analysisEtiologic factors
2012
The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
Lubin JH, Cook MB, Pandeya N, Vaughan TL, Abnet CC, Giffen C, Webb PM, Murray LJ, Casson AG, Risch HA, Ye W, Kamangar F, Bernstein L, Sharp L, Nyrén O, Gammon MD, Corley DA, Wu AH, Brown LM, Chow WH, Ward MH, Freedman ND, Whiteman DC. The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Cancer Epidemiology 2012, 36: 306-316. PMID: 22504051, PMCID: PMC3489030, DOI: 10.1016/j.canep.2012.03.001.Peer-Reviewed Original ResearchConceptsEsophagogastric junctional adenocarcinomaBody mass indexSquamous cell carcinomaEsophageal adenocarcinomaEsophageal Adenocarcinoma ConsortiumCigarette smokingAlcohol consumptionAcid refluxCell carcinomaBarrett's esophagusInverse associationEffect modificationYounger ageCigarettes/dayDrinks/dayExposure rateSignificant effect modificationCase-control studyTotal exposureHigh exposure rateEvaluated effect modificationJunctional adenocarcinomaMass indexSmoking effectsOdds ratio
2011
Clinical impact of unclassified variants of the BRCA1 and BRCA2 genes
Akbari MR, Zhang S, Fan I, Royer R, Li S, Risch H, McLaughlin J, Rosen B, Sun P, Narod SA. Clinical impact of unclassified variants of the BRCA1 and BRCA2 genes. Journal Of Medical Genetics 2011, 48: 783. PMID: 21965345, DOI: 10.1136/jmedgenet-2011-100305.Peer-Reviewed Original ResearchConceptsFirst-degree relativesFemale first-degree relativesRelatives of patientsOvarian cancerCumulative riskPathogenic mutationsUnclassified variantsRisk of cancerHistorical cohortBRCA2 mutationsClinical impactHigh riskBRCA2 genesCancerUnknown significancePatientsMissense variantsFunctional effectsWomenRiskBRCA1PenetranceMutationsRelativesCohortLong‐term overweight and weight gain in early adulthood in association with risk of endometrial cancer
Lu L, Risch H, Irwin ML, Mayne ST, Cartmel B, Schwartz P, Rutherford T, Yu H. Long‐term overweight and weight gain in early adulthood in association with risk of endometrial cancer. International Journal Of Cancer 2011, 129: 1237-1243. PMID: 21387312, PMCID: PMC3125463, DOI: 10.1002/ijc.26046.Peer-Reviewed Original ResearchConceptsBody mass indexLong-term overweightEndometrial cancerSubstantial weight gainWeight gainBody weightPopulation-based case-control studyHigher body mass indexEndometrial cancer riskWeight changeDisease 10 yearsEarly adulthoodUnconditional logistic regressionAdult lifeCase-control studyTime of interviewSuch weight changesMass indexNormal weightIncident casesRisk factorsOdds ratioLong-term effectsAge 40Cancer riskFrequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer
Zhang S, Royer R, Li S, McLaughlin JR, Rosen B, Risch HA, Fan I, Bradley L, Shaw PA, Narod SA. Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer. Gynecologic Oncology 2011, 121: 353-357. PMID: 21324516, DOI: 10.1016/j.ygyno.2011.01.020.Peer-Reviewed Original ResearchConceptsInvasive ovarian cancerOvarian cancerFirst-degree relativesMultiplex ligation-dependent probe amplificationUnselected patientsBRCA2 mutationsNon-mucinous ovarian cancerGermline mutationsCombined mutation frequencyPopulation-based seriesOvarian cancer patientsCommon adult cancersSerous ovarian cancerPrevalence of mutationsFrequency of BRCA1Mucinous carcinomaCancer patientsAdult cancersLigation-dependent probe amplificationCancerGenetic testingPatientsWomenBreastBRCA1
1993
Are Female Smokers at Higher Risk for Lung Cancer than Male Smokers?
Risch H, Howe G, Jain M, Burch J, Holowaty E, Miller A. Are Female Smokers at Higher Risk for Lung Cancer than Male Smokers? American Journal Of Epidemiology 1993, 138: 281-293. PMID: 8395141, DOI: 10.1093/oxfordjournals.aje.a116857.Peer-Reviewed Original ResearchConceptsLung cancerOdds ratioElevated riskGreater smoking cessationHigher elevated riskCase-control studyHigher odds ratioLife-style factorsArea of residenceHistologic groupingsMale smokersFemale smokersCigarette smokingSmoking cessationCancer casesHigh riskCigarette consumptionDetailed questioningLifelong historySmokersTobacco productsCancerDuration of timeMale-female differencesSmokingCanadian National Breast Screening Study: first screen results as predictors of future breast cancer risk.
Holowaty P, Miller A, Baines C, Risch H. Canadian National Breast Screening Study: first screen results as predictors of future breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 1993, 2: 11-9. PMID: 8420606.Peer-Reviewed Original ResearchConceptsRisk factorsBreast cancerYears menstruatingPhysical examinationCanadian National Breast Screening StudyNational Breast Screening StudyFuture breast cancer riskSelf-reported risk factorsBreast Screening StudyInvasive breast cancerRisk factor informationSignificant risk factorsBreast cancer riskEtiological risk factorsCharacteristics of womenSelf-administered questionnaireTwo-view mammographic examinationBreast screenStudy populationParenchymal patternsCancer riskMammographic examinationsScreen resultsStudy designFactor information
1989
Mortality from Breast Cancer after Irradiation during Fluoroscopic Examinations in Patients Being Treated for Tuberculosis
Miller A, Howe G, Sherman G, Lindsay J, Yaffe M, Dinner P, Risch H, Preston D. Mortality from Breast Cancer after Irradiation during Fluoroscopic Examinations in Patients Being Treated for Tuberculosis. New England Journal Of Medicine 1989, 321: 1285-1289. PMID: 2797101, DOI: 10.1056/nejm198911093211902.Peer-Reviewed Original ResearchConceptsBreast cancerRelative riskFluoroscopic examinationRadiation-induced breast cancerFirst exposureLinear dose-response relationUse of mammographyYears of ageDose-response relationNumber of deathsTherapeutic pneumothoraxAsymptomatic womenExcess riskLifetime riskAdditive riskCancerWomenSubstantial proportionSmall benefitAgeRadiation dosesRiskTuberculosisMortalityExposure