2007
Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons
Huang H, van den Pol AN. Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons. Journal Of Neuroscience 2007, 27: 11560-11572. PMID: 17959799, PMCID: PMC6673210, DOI: 10.1523/jneurosci.2147-07.2007.Peer-Reviewed Original ResearchConceptsGroup I metabotropic glutamate receptor activationMetabotropic glutamate receptor activationDHPG-induced depolarizationGlutamate receptor activationGroup IHormone neuronsMGluR5 antagonistGreen fluorescent protein-expressing transgenic miceNMDA receptor-mediated postsynaptic currentsReceptor activationExchanger blocker KB-R7943Melanin-concentrating hormone (MCH) neuronsMelanin-Concentrating Hormone NeuronsReceptor-mediated postsynaptic currentsBlockade of mGluR1Selective group IGroup I mGluRsPatch-clamp recordingsMCH neuron activityI mGluRsMCH neuronsHypocretin neuronsSpontaneous EPSCsPostsynaptic mechanismsHypothalamic slicesCannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal
Huang H, Acuna-Goycolea C, Li Y, Cheng HM, Obrietan K, van den Pol AN. Cannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal. Journal Of Neuroscience 2007, 27: 4870-4881. PMID: 17475795, PMCID: PMC6672093, DOI: 10.1523/jneurosci.0732-07.2007.Peer-Reviewed Original ResearchConceptsMelanin-concentrating hormoneHypocretin neuronsMCH cellsCannabinoid actionGreen fluorescent protein-expressing transgenic miceSpike frequencyIonotropic glutamate receptor antagonistsHypocretin/orexin neuronsLocal inhibitory cellsReceptor agonist RSynaptic GABA releaseReceptor antagonist bicucullineGlutamate receptor antagonistsPatch-clamp recordingsGlutamatergic currentsNaphthalenylmethanone mesylatePresynaptic attenuationMiniature IPSCsMCH neuronsAgonist RAntagonist bicucullineGABA releaseOrexin neuronsPostsynaptic effectsSpontaneous IPSCs
2004
Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices
Huang H, Barakat L, Wang D, Bordey A. Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices. The Journal Of Physiology 2004, 560: 721-736. PMID: 15331688, PMCID: PMC1665288, DOI: 10.1113/jphysiol.2004.067801.Peer-Reviewed Original ResearchConceptsWhole-cell patch-clamp recordingsGlycine receptor blockerMouse cerebellar slicesNMDA receptor activationVoltage-dependent inward currentsExtracellular glycine levelsPatch-clamp recordingsDependent glycine transportersReceptor blockersInhibitory neurotransmitterNMDA receptorsGlycine levelsBergmann gliaCerebellar slicesInward currentsReceptor activationGlycine transporterGliaGlycine transportGlyT1Glycine uptakeBlockersAgonistsIntact systemNeurones