2023
Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells
Wang Y, Popovic Z, Charkoftaki G, Garcia-Milian R, Lam T, Thompson D, Chen Y, Vasiliou V. Multi-omics profiling reveals cellular pathways and functions regulated by ALDH1B1 in colon cancer cells. Chemico-Biological Interactions 2023, 384: 110714. PMID: 37716420, PMCID: PMC10807983, DOI: 10.1016/j.cbi.2023.110714.Peer-Reviewed Original ResearchColon cancer cellsCellular stress response pathwaysStress response pathwaysMulti-omics analysisCancer cellsSecond messenger signalingMulti-omics profilingNew molecular informationFunctional annotationCellular functionsResponse pathwaysKinase signalingCellular pathwaysColon adenocarcinoma cell lineHuman colon adenocarcinoma cell lineApoptosis signalingEnrichment analysisAldehyde dehydrogenase 1B1Molecular signaturesAdenocarcinoma cell lineMolecular informationSignalingNovel targetProtein expressionCell lines
2021
Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia
Tuey S, Atilano-Roque A, Charkoftaki G, Thurman J, Nolin T, Joy M. Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia. Xenobiotica 2021, 51: 657-667. PMID: 33870862, DOI: 10.1080/00498254.2021.1909783.Peer-Reviewed Original ResearchConceptsHuman kidney proximal tubule epithelial cellsUraemic serumProtein expressionHuman kidney proximal tubule cellsVitamin D treatmentEffect of cholecalciferolProximal tubule epithelial cellsKidney proximal tubule epithelial cellsKidney proximal tubule cellsDrug transport pathwaysProximal tubule cellsDrug disposition pathwaysEffect of treatmentTubule epithelial cellsMajor vitamin DVitD treatmentVitamin DFunctional assessmentTubule cellsNM dosesEthanol vehicleFunctional expressionCYP enzymesMRNA expressionDisposition pathways