2021
Environmental and sex-specific molecular signatures of glioma causation
Claus EB, Cannataro VL, Gaffney SG, Townsend JP. Environmental and sex-specific molecular signatures of glioma causation. Neuro-Oncology 2021, 24: 29-36. PMID: 33942853, PMCID: PMC8730771, DOI: 10.1093/neuonc/noab103.Peer-Reviewed Original ResearchConceptsIDH wild-type tumorsWild-type tumorsEnvironmental risk factorsIDH-mutant tumorsRisk factorsCases of gliomaMolecular signaturesPIK3CA mutationsPossible risk exposuresMutation subtypesCancer effectsExogenous exposureAdult gliomasTumorsWhole-exome sequencing dataGliomasKinase domainMutational signaturesCancer-causing mutationsMalesFemalesNon-coding regionsPIK3R1SexCancer mutational signatures
2019
Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis
Saunders CN, Cornish AJ, Kinnersley B, Law PJ, Claus EB, Il’yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS. Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis. Neuro-Oncology 2019, 22: 207-215. PMID: 31665421, PMCID: PMC7442418, DOI: 10.1093/neuonc/noz209.Peer-Reviewed Original ResearchConceptsDensity lipoprotein cholesterolGlioma riskLipoprotein cholesterolRisk factorsHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolMultiple potential risk factorsInsulin-like growth factor-1Modifiable risk factorsSystolic blood pressureBody mass indexPotential risk factorsSerum immunoglobulin E.Body fat percentageGrowth factor-1Risk of gliomaFatty acid levelsLack of associationMendelian randomisation analysisBlood pressureTotal cholesterolWaist circumferenceHemoglobin levelsInflammatory factorsMass index
2012
Assessment of Autoantibodies to Meningioma in a Population-based Study
Wiemels JL, Bracci PM, Wrensch M, Schildkraut J, Bondy M, Pfefferle J, Zhou M, Sison J, Calvocoressi L, Claus EB. Assessment of Autoantibodies to Meningioma in a Population-based Study. American Journal Of Epidemiology 2012, 177: 75-83. PMID: 23221727, PMCID: PMC3590036, DOI: 10.1093/aje/kws221.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntigens, NuclearAutoantibodiesBiomarkers, TumorCell Cycle ProteinsDNA-Binding ProteinsEczemaFemaleHumansHypersensitivityMaleMeningiomaMiddle AgedNuclear Matrix-Associated ProteinsPhosphopyruvate HydrataseReceptors, ImmunologicSex FactorsSmokingSocioeconomic FactorsTumor Suppressor ProteinsUnited StatesConceptsImmune functionAssessment of autoantibodiesUS case-control studyPopulation-based studyTumor-associated antigensCase-control studyEnolase 1Case-control differencesNuclear mitotic apparatus protein 1Risk factorsAutoantibody reactivityImmunoglobulin EIntracranial tumorsMeningioma riskDistinctive etiologyMeningiomasInfection statusSerum samplesProtein 1MenFurther researchMulticenterHigh levelsAutoantibodiesPrevious studiesExogenous hormone use, reproductive factors, and risk of intracranial meningioma in females.
Claus EB, Calvocoressi L, Bondy ML, Wrensch M, Wiemels JL, Schildkraut JM. Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females. Journal Of Neurosurgery 2012, 118: 649-56. PMID: 23101448, PMCID: PMC3756881, DOI: 10.3171/2012.9.jns12811.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedBody Mass IndexBreast FeedingConnecticutContraceptives, OralEstrogen Replacement TherapyFemaleHumansMassachusettsMenarcheMeningeal NeoplasmsMeningiomaMenopauseMiddle AgedMultivariate AnalysisNorth CarolinaOdds RatioParityRegistriesReproductive HistoryRisk AssessmentRisk FactorsSan FranciscoSmokingTexasConceptsBody mass indexMeningioma riskMass indexIntracranial meningiomasExogenous hormone useHormone replacement therapyRisk of meningiomaYears of ageCurrent useResidents of ConnecticutHormone medicationWomen 29Postmenopausal womenPremenopausal womenCurrent smokingFertility medicationsOral contraceptivesHormone useMenstrual factorsSignificant positive associationCigarette smokingReplacement therapyRisk factorsReproductive factorsSignificant elevationDental x‐rays and risk of meningioma
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Dental x‐rays and risk of meningioma. Cancer 2012, 118: 4530-4537. PMID: 22492363, PMCID: PMC3396782, DOI: 10.1002/cncr.26625.Peer-Reviewed Original ResearchConceptsRisk of meningiomaDental X-raysModifiable risk factorsIntracranial meningiomasRisk factorsAge 20Population-based case-control studyMain outcome measuresPrimary brain tumorsCase-control studyGreater frequencyPanorex filmsTumor locationBitewing examinationOutcome measuresElevated riskBrain tumorsControl groupMeningiomasYounger ageRadiation exposureAge 10AgePatientsRisk