2014
Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States
Dunn JM, Krause PJ, Davis S, Vannier EG, Fitzpatrick MC, Rollend L, Belperron AA, States SL, Stacey A, Bockenstedt LK, Fish D, Diuk-Wasser MA. Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States. PLOS ONE 2014, 9: e115494. PMID: 25545393, PMCID: PMC4278703, DOI: 10.1371/journal.pone.0115494.Peer-Reviewed Original ResearchConceptsB. microtiB. burgdorferiBabesia microtiLyme diseaseRespective causative agentsSpread of babesiosisI. scapularis larvaeInfected micePrimary reservoir hostHigh prevalenceLeucopus miceMiceHuman babesiosisBorrelia burgdorferiLaboratory dataLarval burdenCausative agentMicrotiBurgdorferiCoinfectionReservoir hostsDiseaseR0 modelBasic reproduction numberEnzootic cycle
2004
Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System
Derdáková M, Dudiòák V, Brei B, Brownstein J, Schwartz I, Fish D. Interaction and Transmission of Two Borrelia burgdorferi Sensu Stricto Strains in a Tick-Rodent Maintenance System. Applied And Environmental Microbiology 2004, 70: 6783-6788. PMID: 15528545, PMCID: PMC525125, DOI: 10.1128/aem.70.11.6783-6788.2004.Peer-Reviewed Original ResearchConceptsB. burgdorferi sensu strictoBurgdorferi sensu strictoXenodiagnostic ticksBorrelia burgdorferi sensu strictoUninfected larval ticksGroups of miceWhite-footed miceTransmission cycleControl miceInfected micePrimary infectionExperimental miceI. scapularis ticksLeucopus miceDouble infectionMiceLyme disease agentInfectionScapularis ticksMajor genotypesWeekly intervalsTransmission dynamicsExperimental groupSame strainLarval ticks
2001
Infection of Mice with the Agent of Human Granulocytic Ehrlichiosis after Different Routes of Inoculation
Hodzic E, Feng S, Fish D, Leutenegger C, Freet K, Barthold S. Infection of Mice with the Agent of Human Granulocytic Ehrlichiosis after Different Routes of Inoculation. The Journal Of Infectious Diseases 2001, 183: 1781-1786. PMID: 11372031, DOI: 10.1086/320735.Peer-Reviewed Original ResearchConceptsBone marrow samplesReal-time polymerase chain reactionPolymerase chain reactionHuman granulocytic ehrlichiosisMarrow samplesDay 20Granulocytic ehrlichiosisInfection of miceRate of infectionKinetics of infectionLymph nodesGene targetsInfected miceC3H miceEarly disseminationVascular perfusionDay 10Experimental infectionInfectionMiceNeedle inoculationChain reactionBloodEhrlichiosisInoculationOspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks
Tsao J, Barbour A, Luke C, Fikrig E, Fish D. OspA Immunization Decreases Transmission of Borrelia burgdorferi Spirochetes from Infected Peromyscus leucopus Mice to Larval Ixodes scapularis Ticks. Vector-Borne And Zoonotic Diseases 2001, 1: 65-74. PMID: 12653137, DOI: 10.1089/153036601750137705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, WildAntibodies, BacterialAntigens, SurfaceArachnid VectorsBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiDisease ReservoirsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFluorescent Antibody Technique, DirectHost-Parasite InteractionsIxodesLarvaLipoproteinsLyme DiseasePeromyscusConceptsControl miceUninfected larval ticksInfection prevalenceLarval Ixodes scapularis ticksB. burgdorferiNumber of spirochetesEnzyme-linked immunosorbentBorrelia burgdorferi spirochetesLevel of immunizationReservoir hostsConcentration of antibodyBorrelia burgdorferi transmissionIxodes scapularis ticksSecond vaccinationImmunized miceInfected miceLarval ticksPrior infectionVaccination programSubsequent riskDecrease transmissionOspA vaccinationDirect immunofluorescenceImmune responseXenodiagnostic ticks
2000
Acquisition of Coinfection and Simultaneous Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Ticks
Levin M, Fish D. Acquisition of Coinfection and Simultaneous Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Ticks. Infection And Immunity 2000, 68: 2183-2186. PMID: 10722618, PMCID: PMC97402, DOI: 10.1128/iai.68.4.2183-2186.2000.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisPrior infection statusGranulocytic ehrlichiosisInfected miceLyme diseaseInfection statusI. scapularis nymphsScapularis ticksSecond pathogenSusceptible hostsScapularis nymphsInfected hostIxodes scapularis ticksPrevious infectionI. scapularis ticksEhrlichia phagocytophilaUninfected ticksInfected ticksMiceBorrelia burgdorferiDiseaseEhrlichiosisBorreliaEvidence of interactionNymphal ticks
1998
Acquisition and Transmission of the Agent of Human Granulocytic Ehrlichiosis by Ixodes scapularis Ticks
Hodzic E, Fish D, Maretzki C, De Silva A, Feng S, Barthold S. Acquisition and Transmission of the Agent of Human Granulocytic Ehrlichiosis by Ixodes scapularis Ticks. Journal Of Clinical Microbiology 1998, 36: 3574-3578. PMID: 9817875, PMCID: PMC105242, DOI: 10.1128/jcm.36.12.3574-3578.1998.Peer-Reviewed Original ResearchConceptsInfected miceHuman granulocytic ehrlichiosisHGE agentIxodes scapularis ticksGranulocytic ehrlichiosisUninfected larval ticksAcquisition of infectionScapularis ticksMedian infectious doseLarval ticksNymphal ticksTick-borne transmissionC3H miceImmunodeficient miceInfectious doseMiceHuman isolatesInfectionOnset of feedingBloodEhrlichiosisPresent studyMammalian hostsCompetitive PCRTicks