2024
Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics
Johnson R, Stopard I, Byrne H, Armstrong P, Brackney D, Lambert B. Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics. PLOS Pathogens 2024, 20: e1011975. PMID: 38557892, PMCID: PMC11008821, DOI: 10.1371/journal.ppat.1011975.Peer-Reviewed Original ResearchConceptsBasal lamina layersInfection dynamicsYellow fever virusEpidemics of severe diseaseMidgut escape barrierDengue virusVirus population dynamicsAmount of virusEstablishment of infectionDose-dependentlyMosquito feeding behaviorDEN virusesExtrinsic incubation periodFever virusMidgut epitheliumBlood feedingFeeding eventsMidgutViral infection dynamicsZika virusAedes aegyptiCourse of infectionEscape barrierAedes albopictusIncubation period
2008
Aedes aegyptiuses RNA interference in defense against Sindbis virus infection
Campbell C, Keene K, Brackney D, Olson K, Blair C, Wilusz J, Foy B. Aedes aegyptiuses RNA interference in defense against Sindbis virus infection. BMC Microbiology 2008, 8: 47. PMID: 18366655, PMCID: PMC2278134, DOI: 10.1186/1471-2180-8-47.Peer-Reviewed Original ResearchConceptsVirus-dependent mannerAgo2 protein levelsVirus-specific siRNAsAnti-viral defense mechanismProtein levelsSINV infectionRNAi componentsAnti-viral defenseRNAi pathwayRNAi responseBlood-fed controlsSmall RNAsDsRNA injectionRecombinant Sindbis virusRNA interferenceTranscript levelsSindbis virus infectionSINV RNAMost populationsStrand RNAPathway activitySINV replicationRNAVirus interactionsDefense mechanisms