2003
Adipose Tissue α-Linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. Adipose Tissue α-Linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica. Circulation 2003, 107: 1586-1591. PMID: 12668490, DOI: 10.1161/01.cir.0000058165.81208.c6.Peer-Reviewed Original ResearchConceptsNonfatal acute myocardial infarctionAcute myocardial infarctionAdipose tissue alpha-linolenic acidAlpha-linolenic acidMyocardial infarctionCardiovascular diseaseFirst nonfatal acute myocardial infarctionMultivariate conditional logistic regression modelPopulation-based case-control studyConditional logistic regression modelsTissue linoleic acidMI risk factorsPopulation control subjectsCase-control studyAdipose tissue samplesArea of residenceLogistic regression modelsTrans fatty acidsΑ-Linolenic AcidCase patientsFatty acidsControl subjectsLowest quintileInverse associationRisk factors
2002
Mercury and the Risk of Coronary Heart Disease in Men
Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, Stampfer MJ, Willett WC. Mercury and the Risk of Coronary Heart Disease in Men. New England Journal Of Medicine 2002, 347: 1755-1760. PMID: 12456851, DOI: 10.1056/nejmoa021437.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseMale health professionalsHigh dietary intakeYears of ageCase-control designMercury levelsSmoking statusTotal mercury exposureControl subjectsLowest quintileRisk factorsDietary intakeCardiovascular diseaseRelative riskCohort membersPrevious historyToenail clippingsHealth professionalsDiseaseConsumption of fishMercury exposureMean mercury levelRiskFish consumption
1999
Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility
García-Closas M, Kelsey K, Hankinson S, Spiegelman D, Springer K, Willett W, Speizer F, Hunter D. Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility. Journal Of The National Cancer Institute 1999, 91: 1960-1964. PMID: 10564681, DOI: 10.1093/jnci/91.22.1960.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase mu 1Breast cancer riskBreast cancerGSTT1 null genotypeCancer riskOdds ratioNull genotypeGSTT1 genesConditional logistic regression modelsEndogenous mutagenic processesGlutathione S-transferase muConfidence intervalsGSTT1 gene deletionGSTT1 gene polymorphismsLogistic regression modelsHomozygous gene deletionBreast cancer susceptibilityTheta 1 genePremenopausal womenProspective cohortCigarette smokingIncident casesDecreased riskControl subjectsGSTT1 genotype
1998
Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson S, Willett W, Manson J, Colditz G, Hunter D, Spiegelman D, Barbieri R, Speizer F. Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 1998, 90: 1292-1299. PMID: 9731736, DOI: 10.1093/jnci/90.17.1292.Peer-Reviewed Original ResearchConceptsSex steroid hormone levelsHormone replacement therapyBreast cancer riskPostmenopausal womenBreast cancerSteroid hormone levelsBlood collectionEstrogen levelsReplacement therapyHormone levelsCancer riskHealth StudyPrevious hormone replacement therapyPlasma sex steroid hormone levelsPostmenopausal estrogen levelsNurses' Health StudyPlasma estrogen levelsLevels of estradiolCase-control studyPlasma androgen levelsBioavailable estradiolMenopausal statusSignificant positive associationControl subjectsLowest quartileStudy of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer
Yoshizawa K, Willett W, Morris S, Stampfer M, Spiegelman D, Rimm E, Giovannucci E. Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer. Journal Of The National Cancer Institute 1998, 90: 1219-1224. PMID: 9719083, DOI: 10.1093/jnci/90.16.1219.Peer-Reviewed Original ResearchConceptsAdvanced prostate cancerProstate cancerProspective studyControl subjectsHealth professionalsSelenium levelsMale health professionalsFurther prospective studiesBody mass indexLong-term selenium intakeSelenium intakeCase-control designHigh selenium intakeLycopene intakeCalcium intakeMass indexPrediagnostic levelsRandomized trialsSmoking statusFat intakeIntervention trialsFamily historyCohort membersDaily supplementToenail clippings