2020
The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk
Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionCardiovascular Health TrialAlcohol consumptionHealth trialsCardiovascular diseaseModerate alcoholNon-fatal ischemic strokeNon-fatal myocardial infarctionPrimary composite endpointCongestive heart failureCoronary heart diseaseModerate alcohol consumersAdults 50 yearsPublic health guidelinesAlcohol use disorderPreferred alcoholic beverageCardiometabolic effectsCardiometabolic riskCarotid revascularizationIschemic strokeSecondary outcomesComposite endpointHeart failurePrimary outcomeMyocardial infarction
2005
Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
Hines LM, Hunter DJ, Stampfer MJ, Spiegelman D, Chu NF, Rifai N, Hankinson SE, Rimm EB. Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. Atherosclerosis 2005, 182: 293-300. PMID: 16051248, DOI: 10.1016/j.atherosclerosis.2005.02.005.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein levelsPostmenopausal hormonesPostmenopausal womenModerate alcohol consumptionHDL levelsOlder-aged menPremenopausal womenAlcohol consumptionADH1C genotypeLipoprotein levelsAged menCoronary heart diseaseMenopausal statusExogenous estrogenMyocardial infarctionHeart diseaseModerate drinkersOlder menFunctional polymorphismsWomenType 1CMenVaried exposureAssociationHigh levels
2004
Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study. Human Reproduction 2004, 19: 1746-1754. PMID: 15218005, PMCID: PMC1876785, DOI: 10.1093/humrep/deh309.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyUterine leiomyomataHealth StudyCaffeine consumptionCigarette smokingMultivariate incidence rate ratiosSelf-reported uterine leiomyomataDrinks/weekConfidence intervalsUS black womenHeavy coffeePremenopausal womenIncident casesOvarian functionLeiomyomataAlcohol consumptionRate ratioHormone metabolismWomenSmokingRiskBeer consumptionBlack womenManganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 989-996. PMID: 15184255, DOI: 10.1158/1055-9965.989.13.6.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortBreast cancerAla alleleCancer riskCurrent smokersCigarette smokingNurses' Health Study cohortManganese superoxide dismutase polymorphismIndependent risk factorPostmenopausal hormone useCase-control studyVal/ValHormone useStudy cohortIncident casesRisk factorsPlasma antioxidantsDismutase polymorphismAlcohol consumptionVal alleleBlood collectionCancerAntioxidant levelsOxidative stress
2003
Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men. Journal Of Nutrition 2003, 133: 3658-3663. PMID: 14608090, DOI: 10.1093/jn/133.11.3658.Peer-Reviewed Original ResearchConceptsPeripheral arterial disease riskCereal fiber intakeArterial disease riskPAD riskFiber intakeInverse associationDisease riskEarly coronary heart diseaseIncident PAD casesFood frequency questionnaireCoronary heart diseaseTotal fiber intakeOverall inverse associationDisease QuestionnaireFrequency questionnaireLowest quintileHeart diseaseCardiovascular diseaseFamily historyPhysical activityPAD casesAlcohol consumptionEnergy intakeIntakeRiskProspective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men
Koh-Banerjee P, Chu NF, Spiegelman D, Rosner B, Colditz G, Willett W, Rimm E. Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. American Journal Of Clinical Nutrition 2003, 78: 719-727. PMID: 14522729, DOI: 10.1093/ajcn/78.4.719.Peer-Reviewed Original ResearchConceptsWaist gainMetabolic equivalent taskWaist circumferenceAssociation of changesPhysical activityUS menAlcohol consumptionLifestyle factorsTrans fatsBody mass indexFiber/dVigorous physical activityAbdominal adipose tissueAbdominal obesityProspective cohortMass indexProspective studySmoking cessationProspective dataChronic diseasesDietary intakeSelf-report questionnairesAdipose tissueFiber consumptionEnergy intakeA Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women
Kroenke CH, Chu NF, Rifai N, Spiegelman D, Hankinson SE, Manson JE, Rimm EB. A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women. Diabetes Care 2003, 26: 1971-1978. PMID: 12832298, DOI: 10.2337/diacare.26.7.1971.Peer-Reviewed Original ResearchConceptsHealth Study IIGlycemic controlAlcohol intakeBiologic markersNurses' Health Study IIBeneficial glycemic effectsAverage alcohol intakeModerate alcohol consumptionMain outcome measuresCross-sectional studyYears of ageAlcohol consumption patternsOverweight womenGlycemic effectsInsulin levelsLifestyle factorsInsulin resistanceDietary factorsInverse associationC-peptideAverage daily consumptionOutcome measuresPhysical activityBlood samplesAlcohol consumptionAlcohol Consumption Patterns and HbA1c, C-Peptide and Insulin Concentrations in Men
Meyer KA, Conigrave KM, Chu NF, Rifai N, Spiegelman D, Stampfer MJ, Rimm EB. Alcohol Consumption Patterns and HbA1c, C-Peptide and Insulin Concentrations in Men. Journal Of The American Nutrition Association 2003, 22: 185-194. PMID: 12805244, DOI: 10.1080/07315724.2003.10719292.Peer-Reviewed Original ResearchConceptsC-peptideInsulin concentrationsAverage alcohol consumptionAlcohol consumptionAlcohol consumption patternsBlood samplesStudy participantsDrinking patternsDisease-free menC-peptide concentrationsModerate alcohol consumptionCross-sectional studyYears of ageFrequent alcohol consumptionFrequency of consumptionEffects of alcoholInsulin levelsBiologic markersInsulin sensitivityInverse associationAverage daily consumptionIrregular drinkersObservational studyAnalysis of insulinHealth professionals
2001
Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria
Willett W, Stampfer M, Chu NF, Spiegelman D, Holmes M, Rimm E. Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria. American Journal Of Epidemiology 2001, 154: 1107-1112. PMID: 11744515, DOI: 10.1093/aje/154.12.1107.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBody Mass IndexBody WeightCholesterol, HDLCohort StudiesCross-Sectional StudiesDiet SurveysDietary FatsDietary FiberDietary ProteinsEnergy IntakeExerciseFastingFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRegression AnalysisReproducibility of ResultsSmokingSurveys and QuestionnairesTriglyceridesConceptsTotal fat intakeFood frequency questionnaireFat intakeTriglyceride levelsFrequency questionnaireDietary fatSemiquantitative food frequency questionnaireHealth Professionals FollowBody mass indexHigh fat intakePlasma lipid levelsMetabolic studiesIntake of proteinCross-sectional analysisProfessionals FollowOverweight menMass indexInverse associationLipid levelsPhysical activityBlood specimensAlcohol consumptionSpecific biomarkersIntakeMultiple regression analysis
2000
A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk.
Hines LM, Hankinson SE, Smith-Warner SA, Spiegelman D, Kelsey KT, Colditz GA, Willett WC, Hunter DJ. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2000, 9: 1099-105. PMID: 11045794.Peer-Reviewed Original ResearchConceptsBreast cancer riskAlcohol dehydrogenase type 3Hormone levelsCancer riskSteroid hormone levelsAlcohol intakeAlcohol consumptionADH3 genotypeHealth StudyADH3 polymorphismIncident breast cancer casesSex hormone-binding globulinOverall breast cancer riskPlasma steroid hormone levelsNurses' Health StudyHormone-binding globulinPartial Pearson correlation coefficientsCase-control studyConditional logistic regressionBreast cancer casesPostmenopausal womenProspective studyDehydroepiandrosterone sulfateRelative riskBreast cancerProspective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration
Cho E, Hankinson SE, Willett WC, Stampfer MJ, Spiegelman D, Speizer FE, Rimm EB, Seddon JM. Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration. JAMA Ophthalmology 2000, 118: 681-688. PMID: 10815161, DOI: 10.1001/archopht.118.5.681.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDProspective studyMacular degenerationAlcohol consumptionRelative riskDiagnosis of AMDSemiquantitative food frequency questionnaireMale health professionalsPooled relative riskFood frequency questionnaireModerate alcohol consumptionVisual acuity lossConfidence intervalsRisk of AgeRelationship of alcoholYears of ageAlcohol intakeAcuity lossRisk factorsPooled estimatesFemale nursesHealth professionalsAdditional subjectsWomen
1999
Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age.
Garland M, Hunter DJ, Colditz GA, Spiegelman DL, Manson JE, Stampfer MJ, Willett WC. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1017-21. PMID: 10566558.Peer-Reviewed Original ResearchConceptsBreast cancer riskMultivariate relative riskAlcohol consumptionCancer riskRelative riskBreast cancerDrinks/weekInvasive breast cancerModerate alcohol consumptionMore drinks/weekAverage lifetime alcohol consumptionLifetime alcohol consumptionWomen age 25Past alcohol consumptionYears of agePostmenopausal womenPremenopausal womenWomen 25Age 25Young womenHeavy drinkingAge 23Drinking levelsWomenFurther studiesProspective Study of Alcohol Consumption Patterns in Relation to Symptomatic Gallstone Disease in Men
Leitzmann M, Giovannucci E, Stampfer M, Spiegelman D, Colditz G, Willett W, Rimm E. Prospective Study of Alcohol Consumption Patterns in Relation to Symptomatic Gallstone Disease in Men. Alcohol Clinical And Experimental Research 1999, 23: 835-841. PMID: 10371403, DOI: 10.1111/j.1530-0277.1999.tb04191.x.Peer-Reviewed Original ResearchConceptsSymptomatic gallstone diseaseGallstone diseaseAlcohol intakeAlcohol consumption patternsDecreased riskAmount of alcoholAlcohol consumptionCohort of menAlcoholic beverage typesSymptomatic gallstonesFrequent intakeModerate intakeProspective studyRisk factorsSignificant associationDiseaseIntakeBeverage typePotential health hazardsRiskMenAlcoholic beveragesHealth hazardsAssociationConsumption patterns
1998
Alcohol and Breast Cancer in Women: A Pooled Analysis of Cohort Studies
Smith-Warner SA, Spiegelman D, Yaun SS, van den Brandt PA, Folsom AR, Goldbohm RA, Graham S, Holmberg L, Howe GR, Marshall JR, Miller AB, Potter JD, Speizer FE, Willett WC, Wolk A, Hunter DJ. Alcohol and Breast Cancer in Women: A Pooled Analysis of Cohort Studies. JAMA 1998, 279: 535-540. PMID: 9480365, DOI: 10.1001/jama.279.7.535.Peer-Reviewed Original ResearchConceptsInvasive breast cancerAlcohol intakeBreast cancerAlcohol consumptionRelative riskIncident invasive breast cancerMultivariate-adjusted relative riskIncident breast cancer casesBeverage-specific alcohol consumptionMultivariate relative riskTotal alcohol intakeFood frequency questionnaireBreast cancer incidenceBreast cancer riskBreast cancer casesRandom-effects modelLong-term intakeCohort studyFrequency questionnaireProspective studyPooled analysisCancer incidenceDiet assessment instrumentsCancer casesNondietary factors
1997
Calcium Intake and the Incidence of Forearm and Hip Fractures among Men 1 , 2
Owusu W, Willett W, Feskanich D, Ascherio A, Spiegelman D, Colditz G. Calcium Intake and the Incidence of Forearm and Hip Fractures among Men 1 , 2. Journal Of Nutrition 1997, 127: 1782-1787. PMID: 9278560, DOI: 10.1093/jn/127.9.1782.Peer-Reviewed Original ResearchConceptsIncidence of forearmCalcium intakeBody mass indexHip fractureRelative riskForearm fracturesComparable relative riskHealth Professionals FollowHigh calcium intakeTotal energy intakeRisk of fractureGlass of milkMen 40Professionals FollowModerate traumaMass indexSmoking statusLifestyle factorsHighest quintileLowest quintileEpidemiologic studiesPhysical activityLower riskAlcohol consumptionEnergy intakeEpidemiologic determinants of endometriosis: A hospital-based case-control study
Signorello L, Harlow B, Cramer D, Spiegelman D, Hill J. Epidemiologic determinants of endometriosis: A hospital-based case-control study. Annals Of Epidemiology 1997, 7: 267-274. PMID: 9177109, DOI: 10.1016/s1047-2797(97)00017-3.Peer-Reviewed Original ResearchConceptsCase-control studyControl groupHospital-based case-control studyInfertility-associated endometriosisBody mass indexConfidence intervalsPrimary control groupRisk of endometriosisEpidemiologic determinantsMenstrual characteristicsInfertile womenMass indexControl womenFertile womenInverse associationRisk factorsWomen's HospitalEndometriosisAlcohol consumptionAlternate control groupsWomenHospitalAssociationControl selectionSmoking
1996
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Research 1996, 56: 4862-4. PMID: 8895734.Peer-Reviewed Original ResearchConceptsVal/Val individualsVal/Val genotypeColorectal cancerOdds ratioVal genotypeHealth Professionals FollowColorectal cancer riskStrong risk factorHigh dietary intakeCase-control studyMore alcoholic drinksMethylenetetrahydrofolate reductase (MTHFR) polymorphismsVariant homozygous genotypeMethylenetetrahydrofolate reductase (MTHFR) geneProfessionals FollowAlcohol intakeInverse associationRisk factorsDietary intakeReduced incidenceMTHFR genotypeCancer riskBlood samplesAlcohol consumptionOncogenic alterations