2010
Megasomes in Leishmania
McMahon-Pratt D, Ueda-Nakamura T, Traub-Csekö Y. Megasomes in Leishmania. Microbiology Monographs 2010, 17: 131-148. DOI: 10.1007/978-3-642-12863-9_6.Peer-Reviewed Original ResearchImportance of lysosomesProtein traffickingLeishmania virulenceResident enzymesMammalian hostsLysosome-like structuresLeishmania mexicana complexParasite existLysosomal hydrolasesTargeting mechanismCysteine proteinasesSerious public health problemPublic health problemMexicana complexPhlebotomine sandfliesLesion amastigotesGenus LeishmaniaAmastigote formsGood targetClassic pathwayPathwayPromastigote formsHealth problemsMegasomesInsects
1998
Leishmania Amastigote Target Antigens: The Challenge of a Stealthy Intracellular Parasite
McMahon-Pratt D, Kima P, Soong L. Leishmania Amastigote Target Antigens: The Challenge of a Stealthy Intracellular Parasite. Trends In Parasitology 1998, 14: 31-34. PMID: 17040687, DOI: 10.1016/s0169-4758(97)01164-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClass II presentation pathwayAmastigote stageMHC class ILeishmanial vaccineLeishmanial antigensAntigen presentationT cellsElicit protectionImmunized hostsPresentation pathwayInfected macrophagesMolecular vaccinesVaccine targetsInfected mammalian hostsClass IIntracellular parasitesVaccineInfectionCandidate moleculesMacrophagesMammalian hostsDevelopmental formsImmunizationAntigenLeishmaniasis
1987
Characterization of Developmentally Regulated Molecules of Leishmania
McMahon-Pratt D, Jaffe C, Kahl L, Langer P, Lohman K, Pan A, Rivas L. Characterization of Developmentally Regulated Molecules of Leishmania. NATO ASI Series 1987, 123-136. DOI: 10.1007/978-3-642-72840-2_14.Peer-Reviewed Original ResearchDevelopmental life cycleMammalian hostsRegulated moleculesParasitic protozoaMechanism of attachmentCell surfaceSpecies-specific antigensSurface membraneLife cycleSandfly vectorGenus LeishmaniaLeishmaniaImmunologic analysisMonoclonal antibodiesPromastigotesProtozoaMacrophagesParasitesAmastigote-specific antigensHostMembraneAlimentary tractAmastigotesMaintenanceIdentification