Deus Thindwa, PhD
Postdoctoral AssociateAbout
Research
Publications
2023
Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study
Phillips M, Antillon M, Bilcke J, Bar-Zeev N, Limani F, Debellut F, Pecenka C, Neuzil K, Gordon M, Thindwa D, Paltiel A, Yaesoubi R, Pitzer V. Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study. BMC Infectious Diseases 2023, 23: 143. PMID: 36890448, PMCID: PMC9993384, DOI: 10.1186/s12879-023-08105-2.Peer-Reviewed Original ResearchConceptsTyphoid Conjugate VaccineRoutine vaccinationReactive vaccinationVaccination strategiesOutbreak settingsMultidrug-resistant Salmonella typhiQueen Elizabeth Central HospitalTyphoid fever epidemicYears of ageMonths of ageCost-effectiveness analysisWorld Health OrganizationConjugate vaccineCentral HospitalRoutine immunizationVaccine deploymentPreventive vaccinationVaccinationTyphoid feverCost-effective strategyAge 15Health OrganizationFever epidemicAntimicrobial resistanceOutbreak definitionsOptimal age targeting for pneumococcal vaccination in older adults; a modelling study.
Thindwa D, Clifford S, Kleynhans J, von Gottberg A, Walaza S, Meiring S, Swarthout TD, Miller E, McIntyre P, Andrews N, Amin-Chowdhury Z, Fry N, Jambo KC, French N, Almeida SCG, Ladhani SN, Heyderman RS, Cohen C, de Cunto Brandileone MC, Flasche S. Optimal age targeting for pneumococcal vaccination in older adults; a modelling study. Nat Commun 2023, 14: 888. PMID: 36797259, DOI: 10.1038/s41467-023-36624-8.Peer-Reviewed Original ResearchUnmasking Pneumococcal Carriage in a High Human Immunodeficiency Virus (HIV) Prevalence Population in two Community Cohorts in South Africa, 2016-2018: The PHIRST Study.
Carrim M, Tempia S, Thindwa D, Martinson NA, Kahn K, Flasche S, Hellferscee O, Treurnicht FK, McMorrow ML, Moyes J, Mkhencele T, Mathunjwa A, Kleynhans J, Lebina L, Mothlaoleng K, Wafawanaka F, Gómez-Olivé FX, Cohen C, von Gottberg A, Wolter N, PHIRST group. Unmasking Pneumococcal Carriage in a High Human Immunodeficiency Virus (HIV) Prevalence Population in two Community Cohorts in South Africa, 2016-2018: The PHIRST Study. Clin Infect Dis 2023, 76: e710-e717. PMID: 35717655, DOI: 10.1093/cid/ciac499.Peer-Reviewed Original ResearchOmicron B.1.1.529 variant infections associated with severe disease are uncommon in a COVID-19 under-vaccinated, high SARS-CoV-2 seroprevalence population in Malawi.
Mseka UL, Mandolo J, Nyoni K, Divala O, Kambalame D, Mapemba D, Kamzati M, Chibwe I, Henrion MYR, Manda K, Thindwa D, Mvula M, Odala B, Kamng'ona R, Dzinza N, Jere KC, Feasey N, Ho A, Amoah AS, Gordon M, Swarthout TD, Crampin A, Heyderman RS, Kagoli M, Chitsa-Banda E, Mitambo C, Phuka J, Chilima B, Kasambara W, Jambo KC, Chauma-Mwale A. Omicron B.1.1.529 variant infections associated with severe disease are uncommon in a COVID-19 under-vaccinated, high SARS-CoV-2 seroprevalence population in Malawi. EClinicalMedicine 2023, 56: 101800. PMID: 36600885, DOI: 10.1016/j.eclinm.2022.101800.Peer-Reviewed Original Research
2022
Waning of antibody levels induced by a 13-valent pneumococcal conjugate vaccine, using a 3 + 0 schedule, within the first year of life among children younger than 5 years in Blantyre, Malawi: an observational, population-level, serosurveillance study.
Swarthout TD, Henrion MYR, Thindwa D, Meiring JE, Mbewe M, Kalizang'Oma A, Brown C, Msefula J, Moyo B, Mataya AA, Barnaba S, Pearce E, Gordon M, Goldblatt D, French N, Heyderman RS. Waning of antibody levels induced by a 13-valent pneumococcal conjugate vaccine, using a 3 + 0 schedule, within the first year of life among children younger than 5 years in Blantyre, Malawi: an observational, population-level, serosurveillance study. Lancet Infect Dis 2022, 22: 1737-1747. PMID: 36029796, DOI: 10.1016/S1473-3099(22)00438-8.Peer-Reviewed Original ResearchQuality of antibody responses by adults and young children to 13-valent pneumococcal conjugate vaccination and Streptococcus pneumoniae colonisation.
Wolf AS, Mitsi E, Jones S, Jochems SP, Roalfe L, Thindwa D, Meiring JE, Msefula J, Bonomali F, Makhaza Jere T, Mbewe M, Collins AM, Gordon SB, Gordon MA, Ferreira DM, French N, Goldblatt D, Heyderman RS, Swarthout TD. Quality of antibody responses by adults and young children to 13-valent pneumococcal conjugate vaccination and Streptococcus pneumoniae colonisation. Vaccine 2022, 40: 7201-7210. PMID: 36210249, DOI: 10.1016/j.vaccine.2022.09.069.Peer-Reviewed Original ResearchRisk factors for pneumococcal carriage in adults living with HIV on antiretroviral therapy in the infant pneumococcal vaccine era in Malawi.
Thindwa D, Mwalukomo TS, Msefula J, Jambo KC, Brown C, Kamng'ona A, Mwansambo C, Ojal J, Flasche S, French N, Heyderman RS, Swarthout TD. Risk factors for pneumococcal carriage in adults living with HIV on antiretroviral therapy in the infant pneumococcal vaccine era in Malawi. AIDS 2022, 36: 2045-2055. PMID: 35983828, DOI: 10.1097/QAD.0000000000003365.Peer-Reviewed Original ResearchHepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi.
Stockdale AJ, Meiring JE, Shawa IT, Thindwa D, Silungwe NM, Mbewe M, Kachala R, Kreuels B, Patel P, Patel P, Henrion MYR, Bar-Zeev N, Swarthout TD, Heyderman RS, Gordon SB, Maria Geretti A, Gordon MA. Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi. J Infect Dis 2022, 226: 871-880. PMID: 34752631, DOI: 10.1093/infdis/jiab562.Peer-Reviewed Original ResearchEffect of patient-delivered household contact tracing and prevention for tuberculosis: A household cluster-randomised trial in Malawi
Kaswaswa K, MacPherson P, Kumwenda M, Mpunga J, Thindwa D, Nliwasa M, Mwapasa M, Odland J, Tomoka T, Chipungu G, Mukaka M, Corbett E. Effect of patient-delivered household contact tracing and prevention for tuberculosis: A household cluster-randomised trial in Malawi. PLOS ONE 2022, 17: e0269219. PMID: 36074775, PMCID: PMC9455850, DOI: 10.1371/journal.pone.0269219.Peer-Reviewed Original ResearchConceptsTB preventive therapyStandard of careHousehold contactsNational guidelinesTB participantsEligible TB patientsMonths of randomisationCluster-randomised trialTRIAL REGISTRATION NUMBERHousehold contact tracingAge 5 yearsLow-resource settingsTB diseaseTB patientsPreventive therapySecondary outcomesTB screeningPrimary outcomeSymptom screeningIntervention armTB diagnosisSymptom screenMAIN OUTCOMEHigh riskTriage toolSocial mixing patterns relevant to infectious diseases spread by close contact in urban Blantyre, Malawi
Thindwa D, Jambo K, Ojal J, MacPherson P, Dennis Phiri M, Pinsent A, Khundi M, Chiume L, Gallagher K, Heyderman R, Corbett E, French N, Flasche S. Social mixing patterns relevant to infectious diseases spread by close contact in urban Blantyre, Malawi. Epidemics 2022, 40: 100590. PMID: 35691100, PMCID: PMC9176177, DOI: 10.1016/j.epidem.2022.100590.Peer-Reviewed Original ResearchConceptsUrban BlantyreInfectious diseasesLow COVID-19 incidenceHIV-positive statusCOVID-19 circulationCOVID-19 incidenceCOVID-19 precautionsMedian ageHIV statusBinomial mixed effects modelsPandemic preparednessAge groupsClose contactSkin contactLow-income countriesNegative binomial mixed effects modelUrban MalawiMixed effects modelsSecondary school childrenUnemployed participantsTransmission dynamicsContact reductionAdultsBehavioral changesSchool children