1999
Cell-associated infectious HIV-1 viral load as a predictor of clinical progression and survival among HIV-1 infected injection drug users and homosexual men
Lyles C, Graham N, Astemborski J, Vlahov D, Margolick J, Saah A, Farzadegan H. Cell-associated infectious HIV-1 viral load as a predictor of clinical progression and survival among HIV-1 infected injection drug users and homosexual men. European Journal Of Epidemiology 1999, 15: 99-108. PMID: 10204638, DOI: 10.1023/a:1007556327269.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsBacterial InfectionsCause of DeathCD4 Lymphocyte CountCohort StudiesConfidence IntervalsDisease ProgressionFemaleFollow-Up StudiesHIV InfectionsHIV-1Homosexuality, MaleHumansImmunocompromised HostLeukocytes, MononuclearMalePredictive Value of TestsProportional Hazards ModelsRisk FactorsSubstance Abuse, IntravenousSurvival AnalysisSurvival RateViral LoadViremiaConceptsHIV-1 viral loadViral loadHomosexual menRisk groupsHIV-1Relative hazardDrug usersPeripheral blood mononuclear cellsMicroculture techniqueBlood mononuclear cellsInjection drug usersHIV-1 progressionInitial CD4Clinical progressionMononuclear cellsNegative culturesPredictive valueSurvival analysisBacterial infectionsTotal participantsAIDSProgressionInfectious unitsCells/Death
1998
Comparison of Two Measures of Human Immunodeficiency Virus (HIV) Type 1 Load in HIV Risk Groups
Lyles C, Vlahov D, Farzadegan H, Astemborski J, Margolick J, Masters B, Schroeder J, Quinn T. Comparison of Two Measures of Human Immunodeficiency Virus (HIV) Type 1 Load in HIV Risk Groups. Journal Of Clinical Microbiology 1998, 36: 3647-3652. PMID: 9817889, PMCID: PMC105256, DOI: 10.1128/jcm.36.12.3647-3652.1998.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedCD4 Lymphocyte CountFemaleHIV-1Homosexuality, MaleHumansMaleMiddle AgedRNA, ViralSex FactorsSubstance Abuse, IntravenousConceptsInfectious viral loadInjection drug usersHIV RNA levelsHIV RNA loadViral loadRisk groupsRNA loadViral burdenHuman immunodeficiency virus type 1 (HIV-1) loadHomosexual menPlasma HIV RNA levelsMale injection drug usersFemale injection drug usersHuman immunodeficiency virus type 1Peripheral blood mononuclear cellsImmunodeficiency virus type 1RNA levelsBlood mononuclear cellsHIV risk groupViral RNA loadVirus type 1HIV loadMononuclear cellsDrug usersCell count
1997
Hepatitis A Among Homosexual Men and Injection Drug Users: More Evidence for Vaccination
Villano S, Nelson K, Vlahov D, Purcell R, Saah A, Thomas D. Hepatitis A Among Homosexual Men and Injection Drug Users: More Evidence for Vaccination. Clinical Infectious Diseases 1997, 25: 726-728. PMID: 9314468, DOI: 10.1086/513757.Peer-Reviewed Original ResearchConceptsInjection drug usersInjection drug useHAV infectionBlood donorsHomosexual malesHigh-risk drug use behaviorsDrug usersDrug useGeneral United States populationAge-adjusted prevalenceLow socioeconomic statusDrug use behaviorsUnited States populationHAV vaccineHepatitis ATotal antibodyVirus vaccineHomosexual menSexual partnersInfectionSerum samplesHAVSocioeconomic statusVaccineRiskSeroreactivity to hepatitis E virus in areas where the disease is not endemic
Thomas D, Yarbough P, Vlahov D, Tsarev S, Nelson K, Saah A, Purcell R. Seroreactivity to hepatitis E virus in areas where the disease is not endemic. Journal Of Clinical Microbiology 1997, 35: 1244-1247. PMID: 9114415, PMCID: PMC232737, DOI: 10.1128/jcm.35.5.1244-1247.1997.Peer-Reviewed Original ResearchMeSH KeywordsHepatitis EHepatitis E virusHomosexuality, MaleHumansImmunoassayMaleSubstance Abuse, IntravenousConceptsInjection drug usersHistory of hepatitisVirus antibodiesBlood donorsHigh-risk drug-using practicesHomosexual menHepatitis E virus antibodiesHepatitis E diseaseC virus antibodyHepatitis C antibodyHigh-risk groupHigh-risk populationHigh-risk sexual practicesDrug use practicesHepatitis AE virusC antibodySubclinical infectionB antibodiesE diseaseDrug usersEnzyme immunoassaySerum samplesHomosexual malesInfectionComparison of Neuropsychological Performance between AIDS-Free Injecting Drug Users and Homosexual Men
Concha M, Selnes O, Vlahov D, Nance-Sproson T, Updike M, Royal W, Palenicek J, McArthur J. Comparison of Neuropsychological Performance between AIDS-Free Injecting Drug Users and Homosexual Men. Neuroepidemiology 1997, 16: 78-85. PMID: 9057169, DOI: 10.1159/000109674.Peer-Reviewed Original Research
1996
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Dean M, Carrington M, Winkler C, Huttley G, Smith M, Allikmets R, Goedert J, Buchbinder S, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien S. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science 1996, 273: 1856-1862. PMID: 8791590, DOI: 10.1126/science.273.5283.1856.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBase SequenceChromosome MappingChromosomes, Human, Pair 3Cohort StudiesDisease ProgressionGenesHemophilia AHeterozygoteHIV InfectionsHIV-1Homosexuality, MaleHomozygoteHumansImmunity, InnateMaleMolecular Sequence DataReceptors, CCR5Receptors, CytokineReceptors, HIVRisk FactorsSequence DeletionSurvival AnalysisConceptsHIV-1 infectionHIV-1-infected individualsAntibody-negative individualsCohort studyRapid progressorsHuman immunodeficiencyDisease progressionRisk groupsT lymphocytesGenetic restrictionSurvival analysisInfected individualsDeletion alleleCaucasian populationInfectionAIDSProgressionHuman chromosome 3p21Secondary receptorGroup of individualsChromosome 3p21Certain strainsDeletion homozygotesIndividualsProgressorsCategory of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion
Pezzotti P, Phillips A, Dorrucci M, Lepri A, Galai N, Vlahov D, Rezza G. Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion. The BMJ 1996, 313: 583. PMID: 8806246, PMCID: PMC2352019, DOI: 10.1136/bmj.313.7057.583.Peer-Reviewed Original ResearchConceptsDate of seroconversionCategories of exposureExposure categoriesOlder subjectsInjected drugsMore rapid progressionHeterosexual sexLongitudinal studyHomosexual sexHIV treatmentAIDS pathogenesisUnivariate analysisRapid progressionAge effectsYoung subjectsHomosexual menHIVRate of developmentEvidence of differencesDisease controlAIDSSeroconversionSexAgeDefinitions of CenterRE: “DETERMINANTS OF HIV DISEASE PROGRESSION AMONG HOMOSEXUAL MEN REGISTERED IN THE TRICONTINENTAL SEROCONVERTER STUDY” AND “PROGRESSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) INFECTION AMONG HOMOSEXUAL MEN IN HEPATITIS B VACCINE TRIAL COHORTS IN AMSTERDAM, NEW YORK CITY, AND SAN FRANCISCO, 1978–1991”
Zwahlen M, Vlahov D, Hoover D. RE: “DETERMINANTS OF HIV DISEASE PROGRESSION AMONG HOMOSEXUAL MEN REGISTERED IN THE TRICONTINENTAL SEROCONVERTER STUDY” AND “PROGRESSION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) INFECTION AMONG HOMOSEXUAL MEN IN HEPATITIS B VACCINE TRIAL COHORTS IN AMSTERDAM, NEW YORK CITY, AND SAN FRANCISCO, 1978–1991”. American Journal Of Epidemiology 1996, 143: 523-525. PMID: 8610669, DOI: 10.1093/oxfordjournals.aje.a008775.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeCohort StudiesHepatitis B VaccinesHIV SeropositivityHIV-1Homosexuality, MaleHumansMaleNetherlandsUnited States
1995
Changes in Markers of Disease Progression in HIV-1 Seroconverters
Galai N, Vlahov D, Margolick J, Chen K, Graham N, Munoz A. Changes in Markers of Disease Progression in HIV-1 Seroconverters. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 8: 66-82. PMID: 8548349, DOI: 10.1097/00042560-199501000-00011.Peer-Reviewed Original ResearchConceptsHomosexual menDrug usersDisease progressionRisk groupsHuman immunodeficiency virus (HIV) disease progressionHIV-1 seroconversionHIV-1 seroconvertersT lymphocyte subsetsImmune deficiency syndromeWhite homosexual menCD8 percentagesTotal lymphocytesHIV infectionSimilar CD4HIV seroconvertersDeficiency syndromeInitial courseSeroconversionCD4Long incubation periodSeroconvertersMenCohortInfectionSimilar rates