1999
Comparison between a Whole Blood Interferon-γ Release Assay and Tuberculin Skin Testing for the Detection of Tuberculosis Infection among Patients at Risk for Tuberculosis Exposure
Kimura M, Converse P, Astemborski J, Rothel J, Vlahov D, Comstock G, Graham N, Chaisson R, Bishai W. Comparison between a Whole Blood Interferon-γ Release Assay and Tuberculin Skin Testing for the Detection of Tuberculosis Infection among Patients at Risk for Tuberculosis Exposure. The Journal Of Infectious Diseases 1999, 179: 1297-1300. PMID: 10191241, DOI: 10.1086/314707.Peer-Reviewed Original ResearchConceptsTuberculin skin testIFN-gamma releaseTuberculosis infectionWhole-Blood Interferon-γ Release AssayStandard tuberculin skin testInterferon-γ release assaysPercent agreementCulture-confirmed tuberculosisHIV-seropositive subjectsTuberculin skin testingHuman immunodeficiency virusInterferon-gamma releaseIntravenous drug usersSingle blood drawSeronegative patientsTuberculosis exposureSkin testingUninfected personsImmunodeficiency virusSkin testBlood drawUrban BaltimoreDrug usersRelease assaysFurther evaluation
1996
Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation.
Goletti D, Weissman D, Jackson R, Graham N, Vlahov D, Klein R, Munsiff S, Ortona L, Cauda R, Fauci A. Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation. The Journal Of Immunology 1996, 157: 1271-8. PMID: 8757635, DOI: 10.4049/jimmunol.157.3.1271.Peer-Reviewed Original ResearchConceptsHIV replicationMTB diseaseMycobacterium tuberculosisLymph node mononuclear cellsViral replicationCellular activationProtein derivative positivityPlasma viral loadAg-specific activationT cell-depleted lymphocytesPPD-negative donorsHIV diseaseHIV infectionAcute phaseViral loadImmune activationMononuclear cellsPPD positivityHealthy donorsHIV epidemicT cellsPrimary PBMCsHIV infection modelEpidemiology dataHIV