2008
Prevalence and Correlates of Previous Hepatitis B Vaccination and Infection Among Young Drug-users In New York City
Amesty S, Ompad D, Galea S, Fuller C, Wu Y, Koblin B, Vlahov D. Prevalence and Correlates of Previous Hepatitis B Vaccination and Infection Among Young Drug-users In New York City. Journal Of Community Health 2008, 33: 139-148. PMID: 18185987, DOI: 10.1007/s10900-007-9082-4.Peer-Reviewed Original ResearchConceptsEvidence of infectionHBV vaccinationPrevious vaccinationSerological evidenceHepatitis B vaccination coveragePrevious hepatitis B vaccinationPrevious HBV infectionPrevious HBV vaccinationHepatitis B vaccinationHepatitis B vaccineHigh-risk groupYears of ageCommunity-based sampleB vaccinationHBV infectionB vaccineVaccination statusVaccination coverageRisk groupsHigh school educationVaccinationSusceptible individualsDrug usersInfection rateBivariate analysis
1999
Comparison of Clinical Manifestations of HIV Infection Among Women by Risk Group, CD4+ Cell Count, and HIV-1 Plasma Viral Load
Rompalo A, Astemborski J, Schoenbaum E, Schuman P, Carpenter C, Holmberg S, Warren D, Farzadegan H, Vlahov D, Smith D. Comparison of Clinical Manifestations of HIV Infection Among Women by Risk Group, CD4+ Cell Count, and HIV-1 Plasma Viral Load. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1999, 20: 448-454. PMID: 10225226, DOI: 10.1097/00042560-199904150-00006.Peer-Reviewed Original ResearchConceptsHIV-1 viral loadPlasma viral loadBody mass indexHIV-1 plasma viral loadOral hairy leukoplakiaInjection drug useViral loadInjection drug usersRisk groupsHIV infectionCell countDrug useHairy leukoplakiaCells/Clinical manifestationsHeterosexual contactMedian HIV-1 viral loadPlasma HIV-1 viral loadUndetectable HIV-1 viral loadPlasma viral load levelsHIV viral loadIntravenous drug useViral load levelsPopulation of HIVPrevalence of HIVCell-associated infectious HIV-1 viral load as a predictor of clinical progression and survival among HIV-1 infected injection drug users and homosexual men
Lyles C, Graham N, Astemborski J, Vlahov D, Margolick J, Saah A, Farzadegan H. Cell-associated infectious HIV-1 viral load as a predictor of clinical progression and survival among HIV-1 infected injection drug users and homosexual men. European Journal Of Epidemiology 1999, 15: 99-108. PMID: 10204638, DOI: 10.1023/a:1007556327269.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS-Related Opportunistic InfectionsBacterial InfectionsCause of DeathCD4 Lymphocyte CountCohort StudiesConfidence IntervalsDisease ProgressionFemaleFollow-Up StudiesHIV InfectionsHIV-1Homosexuality, MaleHumansImmunocompromised HostLeukocytes, MononuclearMalePredictive Value of TestsProportional Hazards ModelsRisk FactorsSubstance Abuse, IntravenousSurvival AnalysisSurvival RateViral LoadViremiaConceptsHIV-1 viral loadViral loadHomosexual menRisk groupsHIV-1Relative hazardDrug usersPeripheral blood mononuclear cellsMicroculture techniqueBlood mononuclear cellsInjection drug usersHIV-1 progressionInitial CD4Clinical progressionMononuclear cellsNegative culturesPredictive valueSurvival analysisBacterial infectionsTotal participantsAIDSProgressionInfectious unitsCells/Death
1998
Comparison of Two Measures of Human Immunodeficiency Virus (HIV) Type 1 Load in HIV Risk Groups
Lyles C, Vlahov D, Farzadegan H, Astemborski J, Margolick J, Masters B, Schroeder J, Quinn T. Comparison of Two Measures of Human Immunodeficiency Virus (HIV) Type 1 Load in HIV Risk Groups. Journal Of Clinical Microbiology 1998, 36: 3647-3652. PMID: 9817889, PMCID: PMC105256, DOI: 10.1128/jcm.36.12.3647-3652.1998.Peer-Reviewed Original ResearchConceptsInfectious viral loadInjection drug usersHIV RNA levelsHIV RNA loadViral loadRisk groupsRNA loadViral burdenHuman immunodeficiency virus type 1 (HIV-1) loadHomosexual menPlasma HIV RNA levelsMale injection drug usersFemale injection drug usersHuman immunodeficiency virus type 1Peripheral blood mononuclear cellsImmunodeficiency virus type 1RNA levelsBlood mononuclear cellsHIV risk groupViral RNA loadVirus type 1HIV loadMononuclear cellsDrug usersCell count
1997
Markers of response to zidovudine monotherapy among treated HIV seroconverters. Italian Seroconversion Study.
Rezza G, Galai N, Pezzotti P, Vlahov D, Graham N, Viale P, Angarano G. Markers of response to zidovudine monotherapy among treated HIV seroconverters. Italian Seroconversion Study. Antiviral Therapy 1997, 2: 167-74. PMID: 11322271.Peer-Reviewed Original ResearchConceptsCD4 cell countInitiation of treatmentZidovudine monotherapyP24 antigenaemiaCell countConstitutional symptomsHIV seroconvertersRisk groupsCopies/Human immunodeficiency virus seroconvertersPlasma RNA viral loadHIV RNA copiesCD4 cell declineRNA viral loadStart of therapyMarker of responseAntigen-positive individualsAdditional predictive informationIndicator of responseStandard survival methodsTerms of progressionAntiretroviral therapyViral loadAntigen levelsDisease progression
1996
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Dean M, Carrington M, Winkler C, Huttley G, Smith M, Allikmets R, Goedert J, Buchbinder S, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien S. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science 1996, 273: 1856-1862. PMID: 8791590, DOI: 10.1126/science.273.5283.1856.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBase SequenceChromosome MappingChromosomes, Human, Pair 3Cohort StudiesDisease ProgressionGenesHemophilia AHeterozygoteHIV InfectionsHIV-1Homosexuality, MaleHomozygoteHumansImmunity, InnateMaleMolecular Sequence DataReceptors, CCR5Receptors, CytokineReceptors, HIVRisk FactorsSequence DeletionSurvival AnalysisConceptsHIV-1 infectionHIV-1-infected individualsAntibody-negative individualsCohort studyRapid progressorsHuman immunodeficiencyDisease progressionRisk groupsT lymphocytesGenetic restrictionSurvival analysisInfected individualsDeletion alleleCaucasian populationInfectionAIDSProgressionHuman chromosome 3p21Secondary receptorGroup of individualsChromosome 3p21Certain strainsDeletion homozygotesIndividualsProgressorsEvidence for HIV Type 1 Strains of U.S. Intravenous Drug Users as Founders of AIDS Epidemic among Intravenous Drug Users in Northern Europe
Lukashov V, Kuiken C, Vlahov D, Coutinho R, Goudsmit J. Evidence for HIV Type 1 Strains of U.S. Intravenous Drug Users as Founders of AIDS Epidemic among Intravenous Drug Users in Northern Europe. AIDS Research And Human Retroviruses 1996, 12: 1179-1183. PMID: 8844022, DOI: 10.1089/aid.1996.12.1179.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHomosexual menDrug usersV3 sequencesEuropean intravenous drug usersHIV Type 1 StrainsAIDS epidemicHIV-1 epidemicGp120 V3 loopSignature pattern analysisType 1 strainsRisk groupsV3 loopEpidemiological linkMenEpidemicVirusUnited StatesSuggestive evidencePresent suggestive evidenceHigh levelsNucleotide substitutionsEuropean originExistence and Failure of T-Cell Homeostasis Prior to AIDS Onset in HIV-Infected Injection Drug Users
Galai N, Margolick J, Astemborski J, Vlahov D. Existence and Failure of T-Cell Homeostasis Prior to AIDS Onset in HIV-Infected Injection Drug Users. Clinical Immunology 1996, 79: 134-141. PMID: 8620619, DOI: 10.1006/clin.1996.0060.Peer-Reviewed Original ResearchConceptsInjection drug usersTotal T cellsT cell homeostasisT cellsHIV infectionAIDS onsetAIDS diagnosisHomosexual menDrug usersCurrent injection drug useSeropositive injection drug usersInjection drug useT cell levelsImportant prognostic valueALIVE studyClinic visitsPrognostic valueRisk groupsT lymphocytesAIDS casesLate failureDrug useHIVAIDSMonthsTemporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992
Galai N, Lepri A, Vlahov D, Pezzotti P, Sinicco A, Rezza G, Study H. Temporal Trends of Initial CD4 Cell Counts Following Human Immunodeficiency Virus Seroconversion in Italy, 1985–1992. American Journal Of Epidemiology 1996, 143: 278-282. PMID: 8561162, DOI: 10.1093/oxfordjournals.aje.a008739.Peer-Reviewed Original ResearchConceptsCD4 cell measurementsInitial CD4 cell countHuman immunodeficiency virus (HIV) seroconversionCD4 cell countCell countCD4 cell count increaseItalian Seroconversion StudyLow CD4 countMonths of seroconversionYear of seroconversionCD4 cell levelsCell count increaseMedian lag timeCD4 countCD4 levelsHIV seroconversionPositive serologyNegative serologyHIV seroconvertersClinical centersRisk groupsSeroconversion StudySeroconversionMultivariate modelLag timeIncidence and risk factors for HIV-1 infection—a summary of what is known and the psychiatric relevance
Hoover D, Doherty M, Vlahov D, Miotti P. Incidence and risk factors for HIV-1 infection—a summary of what is known and the psychiatric relevance. International Review Of Psychiatry 1996, 8: 137-148. DOI: 10.3109/09540269609046298.Peer-Reviewed Original ResearchInjection drug useHIV-1 transmissionInfected mothersHuman immunodeficiency virus type 1 (HIV-1) epidemicDrug useSexual HIV-1 transmissionGreatest killerHIV-1 diseaseRisky drug useHIV-1 infectionType 1 epidemicHIV-1 epidemicRisk of infectionRisk of transmissionUse of condomsZidovudine therapyInfected partnerBreast feedingRisk factorsRisk groupsClean needlesHIV-1AIDS casesInfected personsHomosexual men
1995
Changes in Markers of Disease Progression in HIV-1 Seroconverters
Galai N, Vlahov D, Margolick J, Chen K, Graham N, Munoz A. Changes in Markers of Disease Progression in HIV-1 Seroconverters. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 8: 66-82. PMID: 8548349, DOI: 10.1097/00042560-199501000-00011.Peer-Reviewed Original ResearchConceptsHomosexual menDrug usersDisease progressionRisk groupsHuman immunodeficiency virus (HIV) disease progressionHIV-1 seroconversionHIV-1 seroconvertersT lymphocyte subsetsImmune deficiency syndromeWhite homosexual menCD8 percentagesTotal lymphocytesHIV infectionSimilar CD4HIV seroconvertersDeficiency syndromeInitial courseSeroconversionCD4Long incubation periodSeroconvertersMenCohortInfectionSimilar rates
1993
Comparison of Clinical Symptoms of Human Immunodeficiency Virus Disease Between Intravenous Drug Users and Homosexual Men
Palenicek J, Nelson K, Vlahov D, Galai N, Cohn S, Saah A. Comparison of Clinical Symptoms of Human Immunodeficiency Virus Disease Between Intravenous Drug Users and Homosexual Men. JAMA Internal Medicine 1993, 153: 1806-1812. PMID: 8101438, DOI: 10.1001/archinte.1993.00410150094009.Peer-Reviewed Original ResearchConceptsIntravenous drug usersCD4 cell levelsClinical symptomsDrug usersHomosexual menOral candidiasisHIV infectionPhysical examinationRisk groupsMale intravenous drug usersHuman immunodeficiency virus (HIV) diseaseRisk behavior interviewsCD4 cell countTotal lymphocyte countIntravenous drug useShortness of breathMost clinical symptomsHIV-1 infectionHuman immunodeficiency virusFrequency of symptomsIntermediate outcome measuresCell levelAbnormal hematocritHIV immunosuppressionNight sweats
1990
Antibody to Human T-Lymphotropic Virus Type I/II (HTLV-I/II) Among Male Inmates Entering Maryland Prisons
Vlahov D, Lee H, Taylor E, Canavaggio M, Canner C, Burczak J, Saah A. Antibody to Human T-Lymphotropic Virus Type I/II (HTLV-I/II) Among Male Inmates Entering Maryland Prisons. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1990, 3: 531-535. DOI: 10.1097/00126334-199003050-00010.Peer-Reviewed Original ResearchHuman T-Lymphotropic Virus Type I/IIExact testIncoming male inmatesHIV-1 serostatusIntravenous drug usersPrevalence of HTLVFisher's exact testYears of ageSame calendar periodWestern blot techniqueType I/IIEpidemiological serosurveyMale inmatesScope of infectionRisk groupsCalendar periodHIV-1Drug usersHTLVMaryland prisonsBlot techniqueRoutine operational proceduresAntibodiesYear of entrySerostatusAntibody to Human T-Lymphotropic Virus Type I/II (HTLV-I/II) Among Male Inmates Entering Maryland Prisons
Vlahov D, Lee H, Taylor E, Canavaggio M, Canner C, Burczak J, Saah A. Antibody to Human T-Lymphotropic Virus Type I/II (HTLV-I/II) Among Male Inmates Entering Maryland Prisons. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1990, 3: 531-535. PMID: 1969961, DOI: 10.1097/00126334-199005000-00010.Peer-Reviewed Original ResearchConceptsHuman T-Lymphotropic Virus Type I/IIExact testIncoming male inmatesHIV-1 serostatusIntravenous drug usersPrevalence of HTLVFisher's exact testYears of ageSame calendar periodWestern blot techniqueType I/IIEpidemiological serosurveyScope of infectionMale inmatesCalendar periodRisk groupsHIV-1Drug usersHTLVMaryland prisonsChi 2Blot techniqueRoutine operational proceduresAntibodiesYear of entry