2013
Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population
Manini A, Jacobs M, Vlahov D, Hurd Y. Opioid Receptor Polymorphism A118G Associated with Clinical Severity in a Drug Overdose Population. Journal Of Medical Toxicology 2013, 9: 148-154. PMID: 23318993, PMCID: PMC3648633, DOI: 10.1007/s13181-012-0286-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlternative SplicingAmino Acid SubstitutionBenzodiazepinesCohort StudiesDrug OverdoseFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHeart ArrestHumansMaleNarcoticsPilot ProjectsPolymorphism, Single NucleotideProspective StudiesReceptors, Opioid, muRespiratory InsufficiencySeverity of Illness IndexSympathomimeticsUnited StatesConceptsAcute drug overdoseG variant alleleClinical severityVariant allelesEmergency departmentDrug overdoseSingle nucleotide polymorphismsConsecutive adult ED patientsHuman mu-opioid receptor geneReceptor single nucleotide polymorphismsWorse clinical severityAdult ED patientsObservational cohort studyUrban teaching hospitalMu-opioid receptor geneAbove single nucleotide polymorphismsCohort studyED patientsRespiratory arrestCardiac arrestClinical variablesAcute drugSevere outcomesTeaching hospitalBlood samples
1998
Drug abuse treatment success among needle exchange participants.
Brooner R, Kidorf M, King V, Beilenson P, Svikis D, Vlahov D. Drug abuse treatment success among needle exchange participants. Public Health Reports 1998, 113 Suppl 1: 129-39. PMID: 9722818, PMCID: PMC1307735.Peer-Reviewed Original ResearchConceptsNeedle exchange programsOpioid agonist treatment programStandard referral groupTreatment programReferral groupBetter short-term treatment outcomesNew admissionsDrug useHuman immunodeficiency virus (HIV) transmissionShort-term treatment outcomesDrug abuse treatment clinicsGreater baseline severitySelf-reported drug useDrug abuse treatment programsUse of drugsReferral patientsClinical variablesBaseline severityIncidence rateTreatment successTreatment clinicsTreatment outcomesBaseline differencesTreatment responseOutcome measures