2005
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
Dwyer-Nield L, Srebernak M, Barrett B, Ahn J, Cosper P, Meyer A, Kisley L, Bauer A, Thompson D, Malkinson A. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 2005, 26: 1196-1206. PMID: 15746162, DOI: 10.1093/carcin/bgi061.Peer-Reviewed Original ResearchConceptsMouse lung epithelial cell lineLung epithelial cell lineInducible NO synthaseBiosynthetic enzymesEpithelial cell lineCell linesProstaglandin E2Lung tumor-derived cell linesTumor-derived cell linesNon-tumorigenic linesNitric oxidePG biosynthetic enzymesCytokine exposureInhibition of iNOSNormal lung cellsCyclooxygenase-2 activityPhysiological relevanceLung tumor formationLung tumor growthMouse lung tumorsSpontaneous transformantsTumor formationCritical mediatorControl lungsEpithelial cells
2002
Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis.
Kisley L, Barrett B, Bauer A, Dwyer-Nield L, Barthel B, Meyer A, Thompson D, Malkinson A. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Research 2002, 62: 6850-6. PMID: 12460898.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButylated HydroxytolueneCarcinogensEndothelial Growth FactorsImmunohistochemistryIntercellular Signaling Peptides and ProteinsLungLung NeoplasmsLymphokinesMacrophages, AlveolarMaleMiceMice, KnockoutNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIUrethaneVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsLung tumor multiplicityLung tumorigenesisLung tumorsMouse lung tumorigenesisINOS deficiencyINOS (-/-) miceNitric oxideLung inflammationTumor multiplicityLung cancer chemopreventive agentNitric oxide synthase contentInducible nitric oxide synthaseInducible nitric oxide synthase (iNOS) contentMurine lung tumorigenesisVascular endothelial growth factor (VEGF) expressionChronic lung inflammationRole of iNOSLung cancer patientsWhole lung extractsCOX-2 contentAlveolar macrophage infiltrationNitric oxide synthaseWild-type miceBronchiolar Clara cellsMouse lung tumorsCelecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice
Kisley L, Barrett B, Dwyer-Nield L, Bauer A, Thompson D, Malkinson A. Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. Carcinogenesis 2002, 23: 1653-1660. PMID: 12376474, DOI: 10.1093/carcin/23.10.1653.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsLung tumor formationPulmonary inflammationLung tumorigenesisLung tumorsMacrophage infiltrationPGE2 productionTumor formationMice fed control dietCOX-2-specific inhibitorsTwo-stage carcinogenesis protocolCelecoxib-treated miceLung cancer developmentAnti-inflammatory drugsProduction of eicosanoidsFed control dietCyclooxygenase-enzyme expressionDifferent organ systemsChronic administrationPGE2 levelsVascular leakageClinical trialsCarcinogenesis protocolMurine modelHigh risk
2000
Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells
Koffler L, Roshong S, Park I, Cesen‐Cummings K, Thompson D, Dwyer‐Nield L, Rice P, Mamay C, Malkinson A, Ruch R. Growth inhibition in G1 and altered expression of cyclin D1 and p27kip‐1 after forced connexin expression in lung and liver carcinoma cells. Journal Of Cellular Biochemistry 2000, 79: 347-354. PMID: 10972973, DOI: 10.1002/1097-4644(20001201)79:3<347::aid-jcb10>3.0.co;2-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinomaCell CommunicationCell Cycle ProteinsCell DivisionConnexinsCyclin D1Cyclin-Dependent Kinase Inhibitor p27CytokinesDiffusionFluorescent DyesG1 PhaseGap JunctionsGene Expression Regulation, NeoplasticLiver Neoplasms, ExperimentalLung NeoplasmsMiceMicrotubule-Associated ProteinsNeoplasm ProteinsNitric OxideProtein KinasesRatsReceptors, Growth FactorRecombinant Fusion ProteinsTransfectionTumor Cells, CulturedTumor Suppressor ProteinsConceptsGap junctional intercellular communicationRat liver epithelial cellsConnexin expressionE9 cellsLiver epithelial cellsGrowth controlDefective growth controlCyclin D1Growth-related functionsTransfection of Cx43Cell cycle regulatorsCell linesEpithelial cellsGap junction proteinCarcinoma cellsMouse lung carcinoma cellsJunctional intercellular communicationLess cyclin D1Cell cycle distributionCycle regulatorsForced expressionIntercellular communicationS phaseP27kip-1Lung carcinoma cells
1998
Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines
Thompson D, Porter S, Bauer A, Das K, Ou B, Dwyer-Nield L, White C, Malkinson A. Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines. American Journal Of Physiology 1998, 274: l922-l932. PMID: 9609731, DOI: 10.1152/ajplung.1998.274.6.l922.Peer-Reviewed Original ResearchConceptsLung epithelial cell lineEpithelial cell lineLung epithelial cellsNontumorigenic cellsCell linesMurine lung epithelial cell lineEpithelial cellsMurine lung epithelial cellsTumorigenic counterpartsMRNA stabilityE10 cellsTumorigenic cellsWestern blot analysisProtein synthesisNormal progenitor cellsCell's abilityINOS regulationNuclear factor-kappaB activationProgenitor cellsCytokine-induced NO synthesisSpontaneous transformantsBlot analysisInducible NO synthaseMurine linesTransformation alters