2019
Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”
Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW. Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom”. Human Genomics 2019, 13: 11. PMID: 30782214, PMCID: PMC6381713, DOI: 10.1186/s40246-019-0191-9.Peer-Reviewed Original ResearchConceptsMajor urinary protein genesKingdoms of lifeLipocalin gene familyGene familyMUP genesMouse genomeHuman genomeProtein geneChromosome 4Regulation of glucoseBarrel structurePhysiological processesΒ-strandsPhysiological functionsSecretory tissueGenesScent marksPseudogenesGenomeLipid metabolismBloomsEvidence pointsSyntenicImportant roleSteroid hormones
2013
Update of the human and mouse SERPINgene superfamily
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V. Update of the human and mouse SERPINgene superfamily. Human Genomics 2013, 7: 22. PMID: 24172014, PMCID: PMC3880077, DOI: 10.1186/1479-7364-7-22.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEvolution, MolecularGenetic VariationHumansMiceMultigene FamilyPhylogenyProtein ConformationSerpinsConceptsHuman protein-coding genesMultiple paralogous genesProtein-coding genesParalogous genesSerine proteinase inhibitorFunctional genesSerpin geneIntracellular serpinsSerpin familyGenesProteinase inhibitorsSerpinsCancer metastasisFurther characterizationProteinTherapeutic targetChaperonesPseudogenesGenomeBlood clottingImmune functionPotential biomarkersInhibitorsTumorigenesisRole
2011
Update on the aldehyde dehydrogenase gene (ALDH) superfamily
Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Human Genomics 2011, 5: 283. PMID: 21712190, PMCID: PMC3392178, DOI: 10.1186/1479-7364-5-4-283.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAnimalsComputational BiologyEvolution, MolecularHumansMultigene FamilyPhylogenySequence Analysis, DNAConceptsAldehyde dehydrogenase geneALDH genesDehydrogenase geneALDH family membersGene loss eventsBiotechnology Information gene databaseGamma-hydroxybutyric aciduriaWhole-genome sequencingCellular processesHuman genomeEnzymic detoxificationGene databaseExogenous aldehydesProtein sequencingType II hyperprolinaemiaCancer stem cellsEntire complementMolecular basisALDH enzymesGenesFamily membersStem cellsAldehyde metabolismRetinoic acidSjögren-Larsson syndrome
2010
Evolutionary divergence and functions of the human interleukin (IL) gene family
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics 2010, 5: 30. PMID: 21106488, PMCID: PMC3390169, DOI: 10.1186/1479-7364-5-1-30.Peer-Reviewed Original ResearchMeSH KeywordsCluster AnalysisCytokinesEvolution, MolecularHumansInterleukinsMultigene FamilyPhylogenyProtein ConformationTerminology as TopicConceptsHelical cytokinesCell typesAmino acid conservationEvolutionary divergenceOrthologous proteinsEvolutionary relationshipsGene familyImmune cell differentiationCommon structural motifBiological functionsCell differentiationUnique structural featuresExact functionStructural featuresGroup of cytokinesMajor groupsCell proliferationImportant roleImmune systemReceptor-binding propertiesHost immune systemStructural motifsStructural informationContinual competitionNumber of interleukin