2014
Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and Cancer
Heit C, Dong H, Chen Y, Shah YM, Thompson DC, Vasiliou V. Transgenic Mouse Models for Alcohol Metabolism, Toxicity, and Cancer. Advances In Experimental Medicine And Biology 2014, 815: 375-387. PMID: 25427919, PMCID: PMC4323349, DOI: 10.1007/978-3-319-09614-8_22.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsReactive oxygen speciesAldehyde dehydrogenasesCritical biological functionsAlcohol dehydrogenaseFormation of proteinHuman genesBiological functionsMolecular mechanismsVariety of cancersPrimary enzymeGenetic defectsOxygen speciesEnzymeNitrogen speciesEthanol metabolismTransgenic mouse modelOxidative stressSpeciesCytochrome P450Pathogenic eventsMetabolismGenetic polymorphismsAntioxidant mechanismsAlcohol-induced toxicityAlcohol-metabolizing enzymes
2010
Evolutionary divergence and functions of the human interleukin (IL) gene family
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics 2010, 5: 30. PMID: 21106488, PMCID: PMC3390169, DOI: 10.1186/1479-7364-5-1-30.Peer-Reviewed Original ResearchConceptsHelical cytokinesCell typesAmino acid conservationEvolutionary divergenceOrthologous proteinsEvolutionary relationshipsGene familyImmune cell differentiationCommon structural motifBiological functionsCell differentiationUnique structural featuresExact functionStructural featuresGroup of cytokinesMajor groupsCell proliferationImportant roleImmune systemReceptor-binding propertiesHost immune systemStructural motifsStructural informationContinual competitionNumber of interleukin